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Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.

Standard

Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. / Stöter, Martin; Bamberger, Ana-Maria; Aslan, Bilnaz; Kurth, Marion; Speidel, Daniel; Löning, Thomas; Frank, Hans-Georg; Kaufmann, Peter; Löhler, Jürgen; Henne-Bruns, Doris; Deppert, Wolfgang; Knippschild, Uwe.

in: ONCOGENE, Jahrgang 24, Nr. 54, 54, 2005, S. 7964-7975.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Stöter, M, Bamberger, A-M, Aslan, B, Kurth, M, Speidel, D, Löning, T, Frank, H-G, Kaufmann, P, Löhler, J, Henne-Bruns, D, Deppert, W & Knippschild, U 2005, 'Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.', ONCOGENE, Jg. 24, Nr. 54, 54, S. 7964-7975. <http://www.ncbi.nlm.nih.gov/pubmed/16027726?dopt=Citation>

APA

Stöter, M., Bamberger, A-M., Aslan, B., Kurth, M., Speidel, D., Löning, T., Frank, H-G., Kaufmann, P., Löhler, J., Henne-Bruns, D., Deppert, W., & Knippschild, U. (2005). Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. ONCOGENE, 24(54), 7964-7975. [54]. http://www.ncbi.nlm.nih.gov/pubmed/16027726?dopt=Citation

Vancouver

Stöter M, Bamberger A-M, Aslan B, Kurth M, Speidel D, Löning T et al. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. ONCOGENE. 2005;24(54):7964-7975. 54.

Bibtex

@article{2ed99383c65f4b068628c09af6f7831d,
title = "Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.",
abstract = "The serine/threonine-specific casein kinase I delta (CKIdelta) is ubiquitously expressed in all tissues, is p53 dependently induced in stress situations and plays an important role in various cellular processes. Our immunohistochemical analysis of the human placenta revealed strongest expression of CKIdelta in extravillous trophoblast cells and in choriocarcinomas. Investigation of the functional role of CKIdelta in an extravillous trophoblast hybrid cell line revealed that CKIdelta was constitutively localized at the centrosomes and the mitotic spindle. Inhibition of CKIdelta with the CKI-specific inhibitor IC261 led to structural alterations of the centrosomes, the formation of multipolar spindles, the inhibition of mitosis and, in contrast to other cell lines, the induction of apoptosis. Our findings indicate that CKIdelta plays an important role in the mitotic progression and in the survival of cells of trophoblast origin. Therefore, IC261 could provide a new tool in treating choriocarcinomas.",
author = "Martin St{\"o}ter and Ana-Maria Bamberger and Bilnaz Aslan and Marion Kurth and Daniel Speidel and Thomas L{\"o}ning and Hans-Georg Frank and Peter Kaufmann and J{\"u}rgen L{\"o}hler and Doris Henne-Bruns and Wolfgang Deppert and Uwe Knippschild",
year = "2005",
language = "Deutsch",
volume = "24",
pages = "7964--7975",
journal = "ONCOGENE",
issn = "0950-9232",
publisher = "NATURE PUBLISHING GROUP",
number = "54",

}

RIS

TY - JOUR

T1 - Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.

AU - Stöter, Martin

AU - Bamberger, Ana-Maria

AU - Aslan, Bilnaz

AU - Kurth, Marion

AU - Speidel, Daniel

AU - Löning, Thomas

AU - Frank, Hans-Georg

AU - Kaufmann, Peter

AU - Löhler, Jürgen

AU - Henne-Bruns, Doris

AU - Deppert, Wolfgang

AU - Knippschild, Uwe

PY - 2005

Y1 - 2005

N2 - The serine/threonine-specific casein kinase I delta (CKIdelta) is ubiquitously expressed in all tissues, is p53 dependently induced in stress situations and plays an important role in various cellular processes. Our immunohistochemical analysis of the human placenta revealed strongest expression of CKIdelta in extravillous trophoblast cells and in choriocarcinomas. Investigation of the functional role of CKIdelta in an extravillous trophoblast hybrid cell line revealed that CKIdelta was constitutively localized at the centrosomes and the mitotic spindle. Inhibition of CKIdelta with the CKI-specific inhibitor IC261 led to structural alterations of the centrosomes, the formation of multipolar spindles, the inhibition of mitosis and, in contrast to other cell lines, the induction of apoptosis. Our findings indicate that CKIdelta plays an important role in the mitotic progression and in the survival of cells of trophoblast origin. Therefore, IC261 could provide a new tool in treating choriocarcinomas.

AB - The serine/threonine-specific casein kinase I delta (CKIdelta) is ubiquitously expressed in all tissues, is p53 dependently induced in stress situations and plays an important role in various cellular processes. Our immunohistochemical analysis of the human placenta revealed strongest expression of CKIdelta in extravillous trophoblast cells and in choriocarcinomas. Investigation of the functional role of CKIdelta in an extravillous trophoblast hybrid cell line revealed that CKIdelta was constitutively localized at the centrosomes and the mitotic spindle. Inhibition of CKIdelta with the CKI-specific inhibitor IC261 led to structural alterations of the centrosomes, the formation of multipolar spindles, the inhibition of mitosis and, in contrast to other cell lines, the induction of apoptosis. Our findings indicate that CKIdelta plays an important role in the mitotic progression and in the survival of cells of trophoblast origin. Therefore, IC261 could provide a new tool in treating choriocarcinomas.

M3 - SCORING: Zeitschriftenaufsatz

VL - 24

SP - 7964

EP - 7975

JO - ONCOGENE

JF - ONCOGENE

SN - 0950-9232

IS - 54

M1 - 54

ER -