PortalPublikationenInducing myointimal hyperplasia versus atherosclerosis in mi...

Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models

Standard

Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models. / Stubbendorff, Mandy; Hua, Xiaoqin; Deuse, Tobias; Ali, Ziad; Reichenspurner, Hermann; Maegdefessel, Lars; Robbins, Robert C; Schrepfer, Sonja.

in: JOVE-J VIS EXP, Nr. 87, 14.05.2014, S. e51459.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Stubbendorff, M, Hua, X, Deuse, T, Ali, Z, Reichenspurner, H, Maegdefessel, L, Robbins, RC & Schrepfer, S 2014, 'Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models', JOVE-J VIS EXP, Nr. 87, S. e51459. https://doi.org/10.3791/51459

APA

Stubbendorff, M., Hua, X., Deuse, T., Ali, Z., Reichenspurner, H., Maegdefessel, L., Robbins, R. C., & Schrepfer, S. (2014). Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models. JOVE-J VIS EXP, (87), e51459. https://doi.org/10.3791/51459

Vancouver

Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L et al. Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models. JOVE-J VIS EXP. 2014 Mai 14;(87):e51459. https://doi.org/10.3791/51459

Bibtex

@article{ca3660769b464711b026cc81ac736dfe,
title = "Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models",
abstract = "Various in vivo laboratory rodent models for the induction of artery stenosis have been established to mimic diseases that include arterial plaque formation and stenosis, as observed for example in ischemic heart disease. Two highly reproducible mouse models - both resulting in artery stenosis but each underlying a different pathway of development - are introduced here. The models represent the two most common causes of artery stenosis; namely one mouse model for each myointimal hyperplasia, and atherosclerosis are shown. To induce myointimal hyperplasia, a balloon catheter injury of the abdominal aorta is performed. For the development of atherosclerotic plaque, the ApoE -/- mouse model in combination with western fatty diet is used. Different model-adapted options for the measurement and evaluation of the results are named and described in this manuscript. The introduction and comparison of these two models provides information for scientists to choose the appropriate artery stenosis model in accordance to the scientific question asked.",
keywords = "Animals, Apolipoproteins E/deficiency, Atherosclerosis/pathology, Disease Models, Animal, Female, Hyperplasia/pathology, Male, Mice, Mice, Inbred C57BL, Plaque, Atherosclerotic/pathology, Reproducibility of Results, Tunica Intima/pathology",
author = "Mandy Stubbendorff and Xiaoqin Hua and Tobias Deuse and Ziad Ali and Hermann Reichenspurner and Lars Maegdefessel and Robbins, {Robert C} and Sonja Schrepfer",
year = "2014",
month = may,
day = "14",
doi = "10.3791/51459",
language = "English",
pages = "e51459",
journal = "JOVE-J VIS EXP",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "87",

}

RIS

TY - JOUR

T1 - Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models

AU - Stubbendorff, Mandy

AU - Hua, Xiaoqin

AU - Deuse, Tobias

AU - Ali, Ziad

AU - Reichenspurner, Hermann

AU - Maegdefessel, Lars

AU - Robbins, Robert C

AU - Schrepfer, Sonja

PY - 2014/5/14

Y1 - 2014/5/14

N2 - Various in vivo laboratory rodent models for the induction of artery stenosis have been established to mimic diseases that include arterial plaque formation and stenosis, as observed for example in ischemic heart disease. Two highly reproducible mouse models - both resulting in artery stenosis but each underlying a different pathway of development - are introduced here. The models represent the two most common causes of artery stenosis; namely one mouse model for each myointimal hyperplasia, and atherosclerosis are shown. To induce myointimal hyperplasia, a balloon catheter injury of the abdominal aorta is performed. For the development of atherosclerotic plaque, the ApoE -/- mouse model in combination with western fatty diet is used. Different model-adapted options for the measurement and evaluation of the results are named and described in this manuscript. The introduction and comparison of these two models provides information for scientists to choose the appropriate artery stenosis model in accordance to the scientific question asked.

AB - Various in vivo laboratory rodent models for the induction of artery stenosis have been established to mimic diseases that include arterial plaque formation and stenosis, as observed for example in ischemic heart disease. Two highly reproducible mouse models - both resulting in artery stenosis but each underlying a different pathway of development - are introduced here. The models represent the two most common causes of artery stenosis; namely one mouse model for each myointimal hyperplasia, and atherosclerosis are shown. To induce myointimal hyperplasia, a balloon catheter injury of the abdominal aorta is performed. For the development of atherosclerotic plaque, the ApoE -/- mouse model in combination with western fatty diet is used. Different model-adapted options for the measurement and evaluation of the results are named and described in this manuscript. The introduction and comparison of these two models provides information for scientists to choose the appropriate artery stenosis model in accordance to the scientific question asked.

KW - Animals

KW - Apolipoproteins E/deficiency

KW - Atherosclerosis/pathology

KW - Disease Models, Animal

KW - Female

KW - Hyperplasia/pathology

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Plaque, Atherosclerotic/pathology

KW - Reproducibility of Results

KW - Tunica Intima/pathology

U2 - 10.3791/51459

DO - 10.3791/51459

M3 - SCORING: Journal article

C2 - 24893977

SP - e51459

JO - JOVE-J VIS EXP

JF - JOVE-J VIS EXP

SN - 1940-087X

IS - 87

ER -