Increased sensory feedback in Tourette syndrome.
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Increased sensory feedback in Tourette syndrome. / Biermann-Ruben, Katja; Miller, Anastasia; Franzkowiak, Stephanie; Finis, Jennifer; Pollok, Bettina; Wach, Claudia; Südmeyer, Martin; Jonas, Melanie; Thomalla, Götz; Müller-Vahl, Kirsten; Münchau, Alexander; Schnitzler, Alfons.
in: NEUROIMAGE, Jahrgang 63, Nr. 1, 1, 2012, S. 119-125.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Increased sensory feedback in Tourette syndrome.
AU - Biermann-Ruben, Katja
AU - Miller, Anastasia
AU - Franzkowiak, Stephanie
AU - Finis, Jennifer
AU - Pollok, Bettina
AU - Wach, Claudia
AU - Südmeyer, Martin
AU - Jonas, Melanie
AU - Thomalla, Götz
AU - Müller-Vahl, Kirsten
AU - Münchau, Alexander
AU - Schnitzler, Alfons
PY - 2012
Y1 - 2012
N2 - Tourette syndrome (TS) is a neuro-psychiatric disorder being characterized by motor and phonic tics typically preceded by sensory urges. Given the latter the role of the sensory system and sensorimotor interaction in TS has recently gained increased attention. 12 TS patients and 12 matched control subjects performed two tasks, requiring simple finger movements: a Go/NoGo task and a self paced movement task. Neurophysiological data was recorded using magnetoencephalography (MEG). Event related responses around movement onset, i.e. motor field (MF) occurring directly prior to the movement and movement evoked field (MEF) immediately after movement onset were analyzed using dipole modeling. MF peak amplitudes did not differ between groups in either task. In contrast, in both tasks MEF peak amplitudes were increased in TS patients. Moreover, larger MEF amplitudes during self paced movements were inversely correlated with motor tic frequency and severity. Enlarged MEF amplitudes as a marker of early sensory feedback of one's own movements probably represent enlarged sensory input from the periphery resulting from altered subcortical gating. We conclude that TS patients exhibit altered sensory-motor processing involved in voluntary movement control, which might also be successful in tic control.
AB - Tourette syndrome (TS) is a neuro-psychiatric disorder being characterized by motor and phonic tics typically preceded by sensory urges. Given the latter the role of the sensory system and sensorimotor interaction in TS has recently gained increased attention. 12 TS patients and 12 matched control subjects performed two tasks, requiring simple finger movements: a Go/NoGo task and a self paced movement task. Neurophysiological data was recorded using magnetoencephalography (MEG). Event related responses around movement onset, i.e. motor field (MF) occurring directly prior to the movement and movement evoked field (MEF) immediately after movement onset were analyzed using dipole modeling. MF peak amplitudes did not differ between groups in either task. In contrast, in both tasks MEF peak amplitudes were increased in TS patients. Moreover, larger MEF amplitudes during self paced movements were inversely correlated with motor tic frequency and severity. Enlarged MEF amplitudes as a marker of early sensory feedback of one's own movements probably represent enlarged sensory input from the periphery resulting from altered subcortical gating. We conclude that TS patients exhibit altered sensory-motor processing involved in voluntary movement control, which might also be successful in tic control.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Young Adult
KW - Brain Mapping
KW - Magnetoencephalography
KW - Tourette Syndrome/physiopathology
KW - Evoked Potentials, Motor
KW - Movement
KW - Brain/physiopathology
KW - Feedback, Sensory
KW - Volition
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Young Adult
KW - Brain Mapping
KW - Magnetoencephalography
KW - Tourette Syndrome/physiopathology
KW - Evoked Potentials, Motor
KW - Movement
KW - Brain/physiopathology
KW - Feedback, Sensory
KW - Volition
M3 - SCORING: Journal article
VL - 63
SP - 119
EP - 125
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
IS - 1
M1 - 1
ER -