Importance of Tight Junctions in Relation to Skin Barrier Function
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Importance of Tight Junctions in Relation to Skin Barrier Function. / Brandner, Johanna M.
in: Curr Probl Dermatol, Jahrgang 49, 2016, S. 27-37.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Importance of Tight Junctions in Relation to Skin Barrier Function
AU - Brandner, Johanna M
N1 - © 2016 S. Karger AG, Basel.
PY - 2016
Y1 - 2016
N2 - Tight junctions (TJs) are complex cell-cell junctions that form a barrier in the stratum granulosum of mammalian skin. Besides forming a barrier themselves, TJs influence other skin barriers, e.g. the stratum corneum barrier, and are influenced by other skin barriers, e.g. by the chemical, the microbiome, or the immunological barrier and likely by the basement membrane. This review summarizes the dynamic interaction of the TJ barrier with other barriers in the skin and the central role of TJs in skin barrier function.
AB - Tight junctions (TJs) are complex cell-cell junctions that form a barrier in the stratum granulosum of mammalian skin. Besides forming a barrier themselves, TJs influence other skin barriers, e.g. the stratum corneum barrier, and are influenced by other skin barriers, e.g. by the chemical, the microbiome, or the immunological barrier and likely by the basement membrane. This review summarizes the dynamic interaction of the TJ barrier with other barriers in the skin and the central role of TJs in skin barrier function.
U2 - 10.1159/000441541
DO - 10.1159/000441541
M3 - SCORING: Journal article
C2 - 26844895
VL - 49
SP - 27
EP - 37
JO - Curr Probl Dermatol
JF - Curr Probl Dermatol
SN - 1421-5721
ER -