Imaging evidence of early brain tissue degeneration in patients with vanishing white matter disease: a multimodal MR study.
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Imaging evidence of early brain tissue degeneration in patients with vanishing white matter disease: a multimodal MR study. / Ding, Xiao-Qi; Bley, Annette; Ohlenbusch, Andreas; Kohlschütter, Alfried; Fiehler, Jens; Zhu, Wenzhen; Lanfermann, Heinrich.
in: J MAGN RESON IMAGING, Jahrgang 35, Nr. 4, 4, 04.2012, S. 926-932.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Imaging evidence of early brain tissue degeneration in patients with vanishing white matter disease: a multimodal MR study.
AU - Ding, Xiao-Qi
AU - Bley, Annette
AU - Ohlenbusch, Andreas
AU - Kohlschütter, Alfried
AU - Fiehler, Jens
AU - Zhu, Wenzhen
AU - Lanfermann, Heinrich
N1 - Copyright © 2011 Wiley Periodicals, Inc.
PY - 2012/4
Y1 - 2012/4
N2 - To find imaging signs of active degenerative processes in vanishing white matter disease (VWM), six VWM patients and six matched controls underwent MR examinations. The data were analyzed with modified Scheltens scales for morphological findings and determined quantitatively for apparent diffusion coefficient (ADC). Single-voxel MR spectra were acquired at the parietal white matter and analyzed with LCModel. Typical VWM brain lesions were found in all patients accompanied by proton diffusion abnormalities: Increased ADC appeared in brain regions with severe myelin destruction in all patients, and reduced ADC in two of six younger patients in remaining white matter adjacent to the lesions or at the borders around the lesions, who had a short history of the disease (? 1 year). The MR spectroscopy revealed reductions of NAA, Cho, and Cr, which correlate to the grade of white matter abnormalities. An increase of myo-inositol as marker of reactive gliosis was missing. Thus, restricted proton diffusion was evident in younger VWM patients with short history of disease, which in combination with lack of reactive gliosis may reflect early white matter degeneration in VWM. The multimodal MR methods are useful for characterizing such tissue degeneration in brain in vivo.
AB - To find imaging signs of active degenerative processes in vanishing white matter disease (VWM), six VWM patients and six matched controls underwent MR examinations. The data were analyzed with modified Scheltens scales for morphological findings and determined quantitatively for apparent diffusion coefficient (ADC). Single-voxel MR spectra were acquired at the parietal white matter and analyzed with LCModel. Typical VWM brain lesions were found in all patients accompanied by proton diffusion abnormalities: Increased ADC appeared in brain regions with severe myelin destruction in all patients, and reduced ADC in two of six younger patients in remaining white matter adjacent to the lesions or at the borders around the lesions, who had a short history of the disease (? 1 year). The MR spectroscopy revealed reductions of NAA, Cho, and Cr, which correlate to the grade of white matter abnormalities. An increase of myo-inositol as marker of reactive gliosis was missing. Thus, restricted proton diffusion was evident in younger VWM patients with short history of disease, which in combination with lack of reactive gliosis may reflect early white matter degeneration in VWM. The multimodal MR methods are useful for characterizing such tissue degeneration in brain in vivo.
KW - Adolescent
KW - Adult
KW - Brain/pathology
KW - Evidence-Based Medicine
KW - Female
KW - Humans
KW - Infant
KW - Leukoencephalopathies/pathology
KW - Magnetic Resonance Imaging/methods
KW - Male
KW - Nerve Fibers, Myelinated/pathology
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Young Adult
U2 - 10.1002/jmri.23517
DO - 10.1002/jmri.23517
M3 - SCORING: Journal article
C2 - 22128017
VL - 35
SP - 926
EP - 932
JO - J MAGN RESON IMAGING
JF - J MAGN RESON IMAGING
SN - 1053-1807
IS - 4
M1 - 4
ER -
