IgG2 deficiency in uremic children is not restricted to peritoneal dialysis treatment.
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IgG2 deficiency in uremic children is not restricted to peritoneal dialysis treatment. / Kemper, Markus J.; Meyer-Jark, T; Müller-Wiefel, D E.
in: PEDIATR NEPHROL, Jahrgang 11, Nr. 6, 6, 1997, S. 684-686.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - IgG2 deficiency in uremic children is not restricted to peritoneal dialysis treatment.
AU - Kemper, Markus J.
AU - Meyer-Jark, T
AU - Müller-Wiefel, D E
PY - 1997
Y1 - 1997
N2 - To date there are no data concerning IgG subclasses in children with preterminal chronic renal failure (CRF), although a reduction of total serum IgG, including its major subclasses IgG1 and IgG2, has been demonstrated in patients on peritoneal dialysis (PD). Therefore we studied total IgG, IgA, IgM, and IgG subclasses in preterminal CRF (n = 25), PD (n = 22) patients, and 13 age-matched healthy children and also compared results with age-related normal values previously established in 226 healthy children. While total IgG, IgA, IgM, and IgG 1 were comparable, there was a significant deficiency of IgG2 in children both with preterminal CRF and on PD compared with controls. Moreover, the prevalence of IgG2 deficiency compared with age-related normal values was significantly increased not only in PD but also in preterminal CRF patients. We conclude that there are alterations in serum IgG subclasses in children with CRF, with IgG2 deficiency not restricted to PD, but being present in the preterminal state as well.
AB - To date there are no data concerning IgG subclasses in children with preterminal chronic renal failure (CRF), although a reduction of total serum IgG, including its major subclasses IgG1 and IgG2, has been demonstrated in patients on peritoneal dialysis (PD). Therefore we studied total IgG, IgA, IgM, and IgG subclasses in preterminal CRF (n = 25), PD (n = 22) patients, and 13 age-matched healthy children and also compared results with age-related normal values previously established in 226 healthy children. While total IgG, IgA, IgM, and IgG 1 were comparable, there was a significant deficiency of IgG2 in children both with preterminal CRF and on PD compared with controls. Moreover, the prevalence of IgG2 deficiency compared with age-related normal values was significantly increased not only in PD but also in preterminal CRF patients. We conclude that there are alterations in serum IgG subclasses in children with CRF, with IgG2 deficiency not restricted to PD, but being present in the preterminal state as well.
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Cohort Studies
KW - Child
KW - Child, Preschool
KW - Infant
KW - Peritoneal Dialysis
KW - IgG Deficiency/complications/immunology
KW - Immunoglobulin A/immunology
KW - Immunoglobulin G/immunology
KW - Immunoglobulin M/immunology
KW - Uremia/complications/immunology/therapy
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Cohort Studies
KW - Child
KW - Child, Preschool
KW - Infant
KW - Peritoneal Dialysis
KW - IgG Deficiency/complications/immunology
KW - Immunoglobulin A/immunology
KW - Immunoglobulin G/immunology
KW - Immunoglobulin M/immunology
KW - Uremia/complications/immunology/therapy
M3 - SCORING: Journal article
VL - 11
SP - 684
EP - 686
JO - PEDIATR NEPHROL
JF - PEDIATR NEPHROL
SN - 0931-041X
IS - 6
M1 - 6
ER -
