Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.
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Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival. / Deuse, Tobias; Seifert, Martina; Phillips, Neil; Fire, Andrew; Tyan, Dolly; Kay, Mark; Tsao, Philip S; Hua, Xiaoqin; Velden, Joachim; Eiermann, Thomas; Volk, Hans-Dieter; Reichenspurner, Hermann; Robbins, Robert C; Schrepfer, Sonja.
in: CIRCULATION, Jahrgang 124, Nr. 11 Suppl, 11 Suppl, 2011, S. 3-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.
AU - Deuse, Tobias
AU - Seifert, Martina
AU - Phillips, Neil
AU - Fire, Andrew
AU - Tyan, Dolly
AU - Kay, Mark
AU - Tsao, Philip S
AU - Hua, Xiaoqin
AU - Velden, Joachim
AU - Eiermann, Thomas
AU - Volk, Hans-Dieter
AU - Reichenspurner, Hermann
AU - Robbins, Robert C
AU - Schrepfer, Sonja
PY - 2011
Y1 - 2011
N2 - Although human embryonic stem cells (hESC) have enormous potential for cell replacement therapy of heart failure, immune rejection of hESC derivatives inevitably would occur after transplantation. We therefore aimed to generate a hypoantigeneic hESC line with improved survival characteristics.
AB - Although human embryonic stem cells (hESC) have enormous potential for cell replacement therapy of heart failure, immune rejection of hESC derivatives inevitably would occur after transplantation. We therefore aimed to generate a hypoantigeneic hESC line with improved survival characteristics.
KW - Animals
KW - Humans
KW - Male
KW - Time Factors
KW - Cells, Cultured
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Knockout
KW - Models, Animal
KW - Mice, Nude
KW - Mice, SCID
KW - Cell Survival/immunology
KW - Embryonic Stem Cells/cytology/immunology
KW - Gene Knockdown Techniques
KW - Graft Survival/immunology
KW - HLA Antigens/genetics
KW - Immune Tolerance/immunology
KW - Immunosuppression
KW - Stem Cell Transplantation
KW - T-Lymphocytes/immunology
KW - Transplantation, Heterologous/immunology
KW - Animals
KW - Humans
KW - Male
KW - Time Factors
KW - Cells, Cultured
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Knockout
KW - Models, Animal
KW - Mice, Nude
KW - Mice, SCID
KW - Cell Survival/immunology
KW - Embryonic Stem Cells/cytology/immunology
KW - Gene Knockdown Techniques
KW - Graft Survival/immunology
KW - HLA Antigens/genetics
KW - Immune Tolerance/immunology
KW - Immunosuppression
KW - Stem Cell Transplantation
KW - T-Lymphocytes/immunology
KW - Transplantation, Heterologous/immunology
M3 - SCORING: Journal article
VL - 124
SP - 3
EP - 9
JO - CIRCULATION
JF - CIRCULATION
SN - 0009-7322
IS - 11 Suppl
M1 - 11 Suppl
ER -