High serum adiponectin concentration in children with chronic kidney disease.
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High serum adiponectin concentration in children with chronic kidney disease. / Möller, Kristina; Dieterman, Christina; Herich, Lena; Klaassen, Ilka; Kemper, Markus J.; Müller-Wiefel, Dirk E.
in: PEDIATR NEPHROL, Jahrgang 27, Nr. 2, 2, 2012, S. 243-249.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - High serum adiponectin concentration in children with chronic kidney disease.
AU - Möller, Kristina
AU - Dieterman, Christina
AU - Herich, Lena
AU - Klaassen, Ilka
AU - Kemper, Markus J.
AU - Müller-Wiefel, Dirk E.
PY - 2012
Y1 - 2012
N2 - Adiponectin (ADPN) counteracts the inflammatory response of the endothelium, which plays an important role in the development of atherosclerosis in patients with chronic kidney disease (CKD). Data in children with CKD are scarce. We examined serum ADPN concentration in 90 children with various renal disorders: 28 with CKD on conservative treatment (CKD), 21 on regular dialysis treatment (D), and 41 after kidney transplantation (Tx); 27 age-matched healthy children served as controls (C). Body mass index (BMI), estimated glomerular filtration rate (eGFR), lipids, homocysteine, high sensitivity CRP (hsCRP), and systolic blood pressure (SBP) were also measured. Mean serum ADPN concentration was significantly higher in patients with CKD (27.3 ?g/ml ±15.0), on D (34.2 ?g/ml ±14.9), and after Tx (23.6 ?g/ml ±9.5) compared with ADPN levels in C (13.5 ?g/ml ±6.1) (p?<?0.0001). Serum ADPN concentration was inversely related to BMI (p?=?0.001) and SBP (p?=?0.004). In the multiple linear regression analysis, only SBP remained independently associated with ADPN plasma levels. Data show that children with CKD have significantly higher serum ADPN, even after Tx. The protective antiarthrosclerotic effect of ADPN may be mediated by lower SBP, a finding that deserves further study.
AB - Adiponectin (ADPN) counteracts the inflammatory response of the endothelium, which plays an important role in the development of atherosclerosis in patients with chronic kidney disease (CKD). Data in children with CKD are scarce. We examined serum ADPN concentration in 90 children with various renal disorders: 28 with CKD on conservative treatment (CKD), 21 on regular dialysis treatment (D), and 41 after kidney transplantation (Tx); 27 age-matched healthy children served as controls (C). Body mass index (BMI), estimated glomerular filtration rate (eGFR), lipids, homocysteine, high sensitivity CRP (hsCRP), and systolic blood pressure (SBP) were also measured. Mean serum ADPN concentration was significantly higher in patients with CKD (27.3 ?g/ml ±15.0), on D (34.2 ?g/ml ±14.9), and after Tx (23.6 ?g/ml ±9.5) compared with ADPN levels in C (13.5 ?g/ml ±6.1) (p?<?0.0001). Serum ADPN concentration was inversely related to BMI (p?=?0.001) and SBP (p?=?0.004). In the multiple linear regression analysis, only SBP remained independently associated with ADPN plasma levels. Data show that children with CKD have significantly higher serum ADPN, even after Tx. The protective antiarthrosclerotic effect of ADPN may be mediated by lower SBP, a finding that deserves further study.
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Body Mass Index
KW - Child
KW - Child, Preschool
KW - Chronic Disease
KW - Glomerular Filtration Rate
KW - Systole
KW - Adiponectin/blood
KW - C-Reactive Protein/analysis
KW - Kidney Diseases/blood/physiopathology
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Body Mass Index
KW - Child
KW - Child, Preschool
KW - Chronic Disease
KW - Glomerular Filtration Rate
KW - Systole
KW - Adiponectin/blood
KW - C-Reactive Protein/analysis
KW - Kidney Diseases/blood/physiopathology
M3 - SCORING: Journal article
VL - 27
SP - 243
EP - 249
JO - PEDIATR NEPHROL
JF - PEDIATR NEPHROL
SN - 0931-041X
IS - 2
M1 - 2
ER -
