Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.
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Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. / Garcia-Closas, Montserrat; Hall, Per; Nevanlinna, Heli; Pooley, Karen; Morrison, Jonathan; Richesson Douglas, A; Bojesen Stig, E; Nordestgaard Børge, G; Axelsson Christen, K; Arias Jose, I; Milne Roger, L; Ribas, Gloria; González-Neira, Anna; Benítez, Javier; Zamora, Pilar; Brauch, Hiltrud; Justenhoven, Christina; Hamann, Ute; Ko, Yon-Dschun; Bruening, Thomas; Haas, Susanne; Dörk, Thilo; Schürmann, Peter; Hillemanns, Peter; Bogdanova, Natalia; Bremer, Michael; Karstens, Johann Hinrich; Fagerholm, Rainer; Aaltonen, Kirsimari; Aittomäki, Kristiina; von Smitten, Karl; Blomqvist, Carl; Mannermaa, Arto; Uusitupa, Matti; Eskelinen, Matti; Tengström, Maria; Kosma, Veli-Matti; Kataja, Vesa; Chenevix-Trench, Georgia; Spurdle Amanda, B; Beesley, Jonathan; Chen, Xiaoqing; Group, Australian Ovarian Cancer Management; Cancer, Kathleen Cuningham Foundation Consortium For Research Into Familial Breast; Devilee, Peter; van Asperen Christi, J; Jacobi, Catharina E; Tollenaar Rob, A E M; Huijts, Petra E A; Klijn, Jan G M; Chang-Claude, Jenny; Kropp, Silke; Slanger, Tracy; Flesch-Janys, Dieter; Mutschelknauss, Elke; Salazar, Ramona; Wang-Gohrke, Shan; Couch, Fergus; Goode, Ellen L; Olson, Janet E; Vachon, Celine; Fredericksen Zachary, S; Giles Graham, G; Baglietto, Laura; Severi, Gianluca; Hopper, John L; English Dallas, R; Southey, Melissa C; Haiman, Christopher A; Henderson Brian, E; Kolonel, Laurence N; Loic, Le Marchand; Stram, Daniel O; Hunter, David J; Hankinson, Susan E; Cox, David G; Tamimi, Rulla; Kraft, Peter; Sherman, Mark E; Chanock Stephen, J; Lissowska, Jolanta; Brinton, Louise A; Peplonska, Beata; Hooning Maartje, J; Meijers-Heijboer, Han; Collee, J Margriet; van den Ouweland, Ans; Uitterlinden, Andre G; Liu, Jianjun; Lin, Low Yen; Yuqing, Li; Humphreys, Keith; Czene, Kamila; Cox, Angela; Balasubramanian Sabapathy, P; Cross, Simon S; Reed Malcolm, W R; Blows, Fiona; Driver, Kristy; Dunning, Alison; Tyrer, Jonathan; Ponder Bruce, A J; Sangrajrang, Suleeporn; Brennan, Paul; McKay, James; Odefrey, Fabrice; Gabrieau, Valerie; Sigurdson, Alice; Doody, Michele; Struewing Jeffrey, P; Alexander, Bruce; Easton Douglas, F; Pharoah, Paul D.
in: PLOS GENET, Jahrgang 4, Nr. 4, 4, 2008, S. 1000054.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.
AU - Garcia-Closas, Montserrat
AU - Hall, Per
AU - Nevanlinna, Heli
AU - Pooley, Karen
AU - Morrison, Jonathan
AU - Richesson Douglas, A
AU - Bojesen Stig, E
AU - Nordestgaard Børge, G
AU - Axelsson Christen, K
AU - Arias Jose, I
AU - Milne Roger, L
AU - Ribas, Gloria
AU - González-Neira, Anna
AU - Benítez, Javier
AU - Zamora, Pilar
AU - Brauch, Hiltrud
AU - Justenhoven, Christina
AU - Hamann, Ute
AU - Ko, Yon-Dschun
AU - Bruening, Thomas
AU - Haas, Susanne
AU - Dörk, Thilo
AU - Schürmann, Peter
AU - Hillemanns, Peter
AU - Bogdanova, Natalia
AU - Bremer, Michael
AU - Karstens, Johann Hinrich
AU - Fagerholm, Rainer
AU - Aaltonen, Kirsimari
AU - Aittomäki, Kristiina
AU - von Smitten, Karl
AU - Blomqvist, Carl
AU - Mannermaa, Arto
AU - Uusitupa, Matti
AU - Eskelinen, Matti
AU - Tengström, Maria
AU - Kosma, Veli-Matti
AU - Kataja, Vesa
AU - Chenevix-Trench, Georgia
AU - Spurdle Amanda, B
AU - Beesley, Jonathan
AU - Chen, Xiaoqing
AU - Group, Australian Ovarian Cancer Management
AU - Cancer, Kathleen Cuningham Foundation Consortium For Research Into Familial Breast
AU - Devilee, Peter
AU - van Asperen Christi, J
AU - Jacobi, Catharina E
AU - Tollenaar Rob, A E M
AU - Huijts, Petra E A
AU - Klijn, Jan G M
AU - Chang-Claude, Jenny
AU - Kropp, Silke
AU - Slanger, Tracy
AU - Flesch-Janys, Dieter
AU - Mutschelknauss, Elke
AU - Salazar, Ramona
AU - Wang-Gohrke, Shan
AU - Couch, Fergus
AU - Goode, Ellen L
AU - Olson, Janet E
AU - Vachon, Celine
AU - Fredericksen Zachary, S
AU - Giles Graham, G
AU - Baglietto, Laura
AU - Severi, Gianluca
AU - Hopper, John L
AU - English Dallas, R
AU - Southey, Melissa C
AU - Haiman, Christopher A
AU - Henderson Brian, E
AU - Kolonel, Laurence N
AU - Loic, Le Marchand
AU - Stram, Daniel O
AU - Hunter, David J
AU - Hankinson, Susan E
AU - Cox, David G
AU - Tamimi, Rulla
AU - Kraft, Peter
AU - Sherman, Mark E
AU - Chanock Stephen, J
AU - Lissowska, Jolanta
AU - Brinton, Louise A
AU - Peplonska, Beata
AU - Hooning Maartje, J
AU - Meijers-Heijboer, Han
AU - Collee, J Margriet
AU - van den Ouweland, Ans
AU - Uitterlinden, Andre G
AU - Liu, Jianjun
AU - Lin, Low Yen
AU - Yuqing, Li
AU - Humphreys, Keith
AU - Czene, Kamila
AU - Cox, Angela
AU - Balasubramanian Sabapathy, P
AU - Cross, Simon S
AU - Reed Malcolm, W R
AU - Blows, Fiona
AU - Driver, Kristy
AU - Dunning, Alison
AU - Tyrer, Jonathan
AU - Ponder Bruce, A J
AU - Sangrajrang, Suleeporn
AU - Brennan, Paul
AU - McKay, James
AU - Odefrey, Fabrice
AU - Gabrieau, Valerie
AU - Sigurdson, Alice
AU - Doody, Michele
AU - Struewing Jeffrey, P
AU - Alexander, Bruce
AU - Easton Douglas, F
AU - Pharoah, Paul D
PY - 2008
Y1 - 2008
N2 - A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs and breast cancer risk varied by clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls from 20 studies. We also evaluated their influence on overall survival in 13,527 cases from 13 studies. All participants were of European or Asian origin. rs2981582 in FGFR2 was more strongly related to ER-positive (per-allele OR (95%CI) = 1.31 (1.27-1.36)) than ER-negative (1.08 (1.03-1.14)) disease (P for heterogeneity = 10(-13)). This SNP was also more strongly related to PR-positive, low grade and node positive tumors (P = 10(-5), 10(-8), 0.013, respectively). The association for rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10(-4), respectively). The differences in the associations between SNPs in FGFR2 and 8q24 and risk by ER and grade remained significant after permutation adjustment for multiple comparisons and after adjustment for other tumor characteristics. Three SNPs (rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21)). rs13281615 in 8q24 was associated with an improvement in survival after diagnosis (per-allele HR = 0.90 (0.83-0.97). The association was attenuated and non-significant after adjusting for known prognostic factors. Our findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct. Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment.
AB - A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs and breast cancer risk varied by clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls from 20 studies. We also evaluated their influence on overall survival in 13,527 cases from 13 studies. All participants were of European or Asian origin. rs2981582 in FGFR2 was more strongly related to ER-positive (per-allele OR (95%CI) = 1.31 (1.27-1.36)) than ER-negative (1.08 (1.03-1.14)) disease (P for heterogeneity = 10(-13)). This SNP was also more strongly related to PR-positive, low grade and node positive tumors (P = 10(-5), 10(-8), 0.013, respectively). The association for rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10(-4), respectively). The differences in the associations between SNPs in FGFR2 and 8q24 and risk by ER and grade remained significant after permutation adjustment for multiple comparisons and after adjustment for other tumor characteristics. Three SNPs (rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21)). rs13281615 in 8q24 was associated with an improvement in survival after diagnosis (per-allele HR = 0.90 (0.83-0.97). The association was attenuated and non-significant after adjusting for known prognostic factors. Our findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct. Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment.
U2 - 10.1371/journal.pgen.1000054
DO - 10.1371/journal.pgen.1000054
M3 - SCORING: Zeitschriftenaufsatz
VL - 4
SP - 1000054
JO - PLOS GENET
JF - PLOS GENET
SN - 1553-7404
IS - 4
M1 - 4
ER -