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Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells

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Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells. / Follain, Gautier; Osmani, Naël; Azevedo, Ana Sofia; Allio, Guillaume; Mercier, Luc; Karreman, Matthia A; Solecki, Gergely; Garcia Leòn, Marìa Jesùs; Lefebvre, Olivier; Fekonja, Nina; Hille, Claudia; Chabannes, Vincent; Dollé, Guillaume; Metivet, Thibaut; Hovsepian, François Der; Prudhomme, Christophe; Pichot, Angélique; Paul, Nicodème; Carapito, Raphaël; Bahram, Siamak; Ruthensteiner, Bernhard; Kemmling, André; Siemonsen, Susanne; Schneider, Tanja; Fiehler, Jens; Glatzel, Markus; Winkler, Frank; Schwab, Yannick; Pantel, Klaus; Harlepp, Sébastien; Goetz, Jacky G.

in: DEV CELL, Jahrgang 45, Nr. 1, 09.04.2018, S. 33-52.e12.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Follain, G, Osmani, N, Azevedo, AS, Allio, G, Mercier, L, Karreman, MA, Solecki, G, Garcia Leòn, MJ, Lefebvre, O, Fekonja, N, Hille, C, Chabannes, V, Dollé, G, Metivet, T, Hovsepian, FD, Prudhomme, C, Pichot, A, Paul, N, Carapito, R, Bahram, S, Ruthensteiner, B, Kemmling, A, Siemonsen, S, Schneider, T, Fiehler, J, Glatzel, M, Winkler, F, Schwab, Y, Pantel, K, Harlepp, S & Goetz, JG 2018, 'Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells', DEV CELL, Jg. 45, Nr. 1, S. 33-52.e12. https://doi.org/10.1016/j.devcel.2018.02.015

APA

Follain, G., Osmani, N., Azevedo, A. S., Allio, G., Mercier, L., Karreman, M. A., Solecki, G., Garcia Leòn, M. J., Lefebvre, O., Fekonja, N., Hille, C., Chabannes, V., Dollé, G., Metivet, T., Hovsepian, F. D., Prudhomme, C., Pichot, A., Paul, N., Carapito, R., ... Goetz, J. G. (2018). Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells. DEV CELL, 45(1), 33-52.e12. https://doi.org/10.1016/j.devcel.2018.02.015

Vancouver

Follain G, Osmani N, Azevedo AS, Allio G, Mercier L, Karreman MA et al. Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells. DEV CELL. 2018 Apr 9;45(1):33-52.e12. https://doi.org/10.1016/j.devcel.2018.02.015

Bibtex

@article{a6f8a794969f4dbda73f89b92be842a4,
title = "Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells",
abstract = "Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest and the extravasation of circulating tumor cells (CTCs) in vivo. Using the zebrafish embryo, we show that arrest of CTCs occurs in vessels with favorable flow profiles where flow forces control the adhesion efficacy of CTCs to the endothelium. We biophysically identified the threshold values of flow and adhesion forces allowing successful arrest of CTCs. In addition, flow forces fine-tune tumor cell extravasation by impairing the remodeling properties of the endothelium. Importantly, we also observe endothelial remodeling at arrest sites of CTCs in mouse brain capillaries. Finally, we observed that human supratentorial brain metastases preferably develop in areas with low perfusion. These results demonstrate that hemodynamic profiles at metastatic sites regulate key steps of extravasation preceding metastatic outgrowth.",
keywords = "Journal Article",
author = "Gautier Follain and Na{\"e}l Osmani and Azevedo, {Ana Sofia} and Guillaume Allio and Luc Mercier and Karreman, {Matthia A} and Gergely Solecki and {Garcia Le{\`o}n}, {Mar{\`i}a Jes{\`u}s} and Olivier Lefebvre and Nina Fekonja and Claudia Hille and Vincent Chabannes and Guillaume Doll{\'e} and Thibaut Metivet and Hovsepian, {Fran{\c c}ois Der} and Christophe Prudhomme and Ang{\'e}lique Pichot and Nicod{\`e}me Paul and Rapha{\"e}l Carapito and Siamak Bahram and Bernhard Ruthensteiner and Andr{\'e} Kemmling and Susanne Siemonsen and Tanja Schneider and Jens Fiehler and Markus Glatzel and Frank Winkler and Yannick Schwab and Klaus Pantel and S{\'e}bastien Harlepp and Goetz, {Jacky G}",
note = "Copyright {\textcopyright} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = apr,
day = "9",
doi = "10.1016/j.devcel.2018.02.015",
language = "English",
volume = "45",
pages = "33--52.e12",
journal = "DEV CELL",
issn = "1534-5807",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells

AU - Follain, Gautier

AU - Osmani, Naël

AU - Azevedo, Ana Sofia

AU - Allio, Guillaume

AU - Mercier, Luc

AU - Karreman, Matthia A

AU - Solecki, Gergely

AU - Garcia Leòn, Marìa Jesùs

AU - Lefebvre, Olivier

AU - Fekonja, Nina

AU - Hille, Claudia

AU - Chabannes, Vincent

AU - Dollé, Guillaume

AU - Metivet, Thibaut

AU - Hovsepian, François Der

AU - Prudhomme, Christophe

AU - Pichot, Angélique

AU - Paul, Nicodème

AU - Carapito, Raphaël

AU - Bahram, Siamak

AU - Ruthensteiner, Bernhard

AU - Kemmling, André

AU - Siemonsen, Susanne

AU - Schneider, Tanja

AU - Fiehler, Jens

AU - Glatzel, Markus

AU - Winkler, Frank

AU - Schwab, Yannick

AU - Pantel, Klaus

AU - Harlepp, Sébastien

AU - Goetz, Jacky G

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/4/9

Y1 - 2018/4/9

N2 - Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest and the extravasation of circulating tumor cells (CTCs) in vivo. Using the zebrafish embryo, we show that arrest of CTCs occurs in vessels with favorable flow profiles where flow forces control the adhesion efficacy of CTCs to the endothelium. We biophysically identified the threshold values of flow and adhesion forces allowing successful arrest of CTCs. In addition, flow forces fine-tune tumor cell extravasation by impairing the remodeling properties of the endothelium. Importantly, we also observe endothelial remodeling at arrest sites of CTCs in mouse brain capillaries. Finally, we observed that human supratentorial brain metastases preferably develop in areas with low perfusion. These results demonstrate that hemodynamic profiles at metastatic sites regulate key steps of extravasation preceding metastatic outgrowth.

AB - Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest and the extravasation of circulating tumor cells (CTCs) in vivo. Using the zebrafish embryo, we show that arrest of CTCs occurs in vessels with favorable flow profiles where flow forces control the adhesion efficacy of CTCs to the endothelium. We biophysically identified the threshold values of flow and adhesion forces allowing successful arrest of CTCs. In addition, flow forces fine-tune tumor cell extravasation by impairing the remodeling properties of the endothelium. Importantly, we also observe endothelial remodeling at arrest sites of CTCs in mouse brain capillaries. Finally, we observed that human supratentorial brain metastases preferably develop in areas with low perfusion. These results demonstrate that hemodynamic profiles at metastatic sites regulate key steps of extravasation preceding metastatic outgrowth.

KW - Journal Article

U2 - 10.1016/j.devcel.2018.02.015

DO - 10.1016/j.devcel.2018.02.015

M3 - SCORING: Journal article

C2 - 29634935

VL - 45

SP - 33-52.e12

JO - DEV CELL

JF - DEV CELL

SN - 1534-5807

IS - 1

ER -