Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Standard
Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals. / Ripplinger, Crystal M; Glukhov, Alexey V; Kay, Matthew W; Boukens, Bastiaan J; Chiamvimonvat, Nipavan; Delisle, Brian P; Fabritz, Larissa; Hund, Thomas J; Knollmann, Bjorn C; Li, Na; Murray, Katherine T; Poelzing, Steven; Quinn, T Alexander; Remme, Carol Ann; Rentschler, Stacey L; Rose, Robert A; Posnack, Nikki G.
in: AM J PHYSIOL-HEART C, Jahrgang 323, Nr. 6, 01.12.2022, S. H1137-H1166.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
AU - Ripplinger, Crystal M
AU - Glukhov, Alexey V
AU - Kay, Matthew W
AU - Boukens, Bastiaan J
AU - Chiamvimonvat, Nipavan
AU - Delisle, Brian P
AU - Fabritz, Larissa
AU - Hund, Thomas J
AU - Knollmann, Bjorn C
AU - Li, Na
AU - Murray, Katherine T
AU - Poelzing, Steven
AU - Quinn, T Alexander
AU - Remme, Carol Ann
AU - Rentschler, Stacey L
AU - Rose, Robert A
AU - Posnack, Nikki G
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although recent advances in cell-based models, including human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM), are contributing to our understanding of electrophysiology and arrhythmia mechanisms, preclinical animal studies of cardiovascular disease remain a mainstay. Over the past several decades, animal models of cardiovascular disease have advanced our understanding of pathological remodeling, arrhythmia mechanisms, and drug effects and have led to major improvements in pacing and defibrillation therapies. There exist a variety of methodological approaches for the assessment of cardiac electrophysiology and a plethora of parameters may be assessed with each approach. This guidelines article will provide an overview of the strengths and limitations of several common techniques used to assess electrophysiology and arrhythmia mechanisms at the whole animal, whole heart, and tissue level with a focus on small animal models. We also define key electrophysiological parameters that should be assessed, along with their physiological underpinnings, and the best methods with which to assess these parameters.
AB - Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although recent advances in cell-based models, including human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM), are contributing to our understanding of electrophysiology and arrhythmia mechanisms, preclinical animal studies of cardiovascular disease remain a mainstay. Over the past several decades, animal models of cardiovascular disease have advanced our understanding of pathological remodeling, arrhythmia mechanisms, and drug effects and have led to major improvements in pacing and defibrillation therapies. There exist a variety of methodological approaches for the assessment of cardiac electrophysiology and a plethora of parameters may be assessed with each approach. This guidelines article will provide an overview of the strengths and limitations of several common techniques used to assess electrophysiology and arrhythmia mechanisms at the whole animal, whole heart, and tissue level with a focus on small animal models. We also define key electrophysiological parameters that should be assessed, along with their physiological underpinnings, and the best methods with which to assess these parameters.
KW - Animals
KW - Humans
KW - Cardiovascular Diseases
KW - Electrophysiologic Techniques, Cardiac
KW - Arrhythmias, Cardiac/etiology
KW - Induced Pluripotent Stem Cells
KW - Myocytes, Cardiac
U2 - 10.1152/ajpheart.00439.2022
DO - 10.1152/ajpheart.00439.2022
M3 - SCORING: Review article
C2 - 36269644
VL - 323
SP - H1137-H1166
JO - AM J PHYSIOL-HEART C
JF - AM J PHYSIOL-HEART C
SN - 0363-6135
IS - 6
ER -