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Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.

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Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. / Nowacki, Tobias M; Kuerten, Stefanie; Zhang, Wenji; Shive, Carey L; Kreher, Christian; Boehm, Bernhard O; Lehmann, Paul V; Tary-Lehmann, Magdalena.

in: CELL IMMUNOL, Jahrgang 247, Nr. 1, 1, 2007, S. 36-48.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Nowacki, TM, Kuerten, S, Zhang, W, Shive, CL, Kreher, C, Boehm, BO, Lehmann, PV & Tary-Lehmann, M 2007, 'Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.', CELL IMMUNOL, Jg. 247, Nr. 1, 1, S. 36-48. <http://www.ncbi.nlm.nih.gov/pubmed/17825804?dopt=Citation>

APA

Nowacki, T. M., Kuerten, S., Zhang, W., Shive, C. L., Kreher, C., Boehm, B. O., Lehmann, P. V., & Tary-Lehmann, M. (2007). Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. CELL IMMUNOL, 247(1), 36-48. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17825804?dopt=Citation

Vancouver

Nowacki TM, Kuerten S, Zhang W, Shive CL, Kreher C, Boehm BO et al. Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. CELL IMMUNOL. 2007;247(1):36-48. 1.

Bibtex

@article{d523f29e906d4d3f968ad4beb78c51d4,
title = "Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.",
abstract = "For immune diagnostic purposes it would be critical to be able to distinguish between ongoing immune processes, such as active infections, and long-term immune memory, for example imprinted by infections that have been cleared a long time ago or by vaccinations. We tested the hypothesis that the secretion of granzyme B, as detected in ex vivo ELISPOT assays, permits this distinction. We studied EBV-, flu- and CMV-specific CD8(+) cells in healthy individuals, Vaccinia virus-reactive CD8(+) cells in the course of vaccination, and HIV-specific CD8(+) cells in HIV-infected individuals. Antigen-specific ex vivo GzB production was detected only transiently after Vaccinia immunization, and in HIV-infected individuals. Our data suggest that ex vivo ELISPOT measurements of granzyme B permit the identification of actively ongoing CD8(+) cell responses-a notion that is pertinent to the immune diagnostic of infections, transplantation, allergies, autoimmune diseases, tumors and vaccine development.",
author = "Nowacki, {Tobias M} and Stefanie Kuerten and Wenji Zhang and Shive, {Carey L} and Christian Kreher and Boehm, {Bernhard O} and Lehmann, {Paul V} and Magdalena Tary-Lehmann",
year = "2007",
language = "Deutsch",
volume = "247",
pages = "36--48",
journal = "CELL IMMUNOL",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.

AU - Nowacki, Tobias M

AU - Kuerten, Stefanie

AU - Zhang, Wenji

AU - Shive, Carey L

AU - Kreher, Christian

AU - Boehm, Bernhard O

AU - Lehmann, Paul V

AU - Tary-Lehmann, Magdalena

PY - 2007

Y1 - 2007

N2 - For immune diagnostic purposes it would be critical to be able to distinguish between ongoing immune processes, such as active infections, and long-term immune memory, for example imprinted by infections that have been cleared a long time ago or by vaccinations. We tested the hypothesis that the secretion of granzyme B, as detected in ex vivo ELISPOT assays, permits this distinction. We studied EBV-, flu- and CMV-specific CD8(+) cells in healthy individuals, Vaccinia virus-reactive CD8(+) cells in the course of vaccination, and HIV-specific CD8(+) cells in HIV-infected individuals. Antigen-specific ex vivo GzB production was detected only transiently after Vaccinia immunization, and in HIV-infected individuals. Our data suggest that ex vivo ELISPOT measurements of granzyme B permit the identification of actively ongoing CD8(+) cell responses-a notion that is pertinent to the immune diagnostic of infections, transplantation, allergies, autoimmune diseases, tumors and vaccine development.

AB - For immune diagnostic purposes it would be critical to be able to distinguish between ongoing immune processes, such as active infections, and long-term immune memory, for example imprinted by infections that have been cleared a long time ago or by vaccinations. We tested the hypothesis that the secretion of granzyme B, as detected in ex vivo ELISPOT assays, permits this distinction. We studied EBV-, flu- and CMV-specific CD8(+) cells in healthy individuals, Vaccinia virus-reactive CD8(+) cells in the course of vaccination, and HIV-specific CD8(+) cells in HIV-infected individuals. Antigen-specific ex vivo GzB production was detected only transiently after Vaccinia immunization, and in HIV-infected individuals. Our data suggest that ex vivo ELISPOT measurements of granzyme B permit the identification of actively ongoing CD8(+) cell responses-a notion that is pertinent to the immune diagnostic of infections, transplantation, allergies, autoimmune diseases, tumors and vaccine development.

M3 - SCORING: Zeitschriftenaufsatz

VL - 247

SP - 36

EP - 48

JO - CELL IMMUNOL

JF - CELL IMMUNOL

SN - 0008-8749

IS - 1

M1 - 1

ER -