Geschlechtsunterschiede bei Infektionserkrankungen
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Geschlechtsunterschiede bei Infektionserkrankungen. / Beisel, Claudia; Lunzen, Jan; Lohse, Ansgar W; Addo, Marylyn Martina; Altfeld, Marcus.
in: DEUT MED WOCHENSCHR, Jahrgang 140, Nr. 18, 09.2015, S. 1385-90.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Geschlechtsunterschiede bei Infektionserkrankungen
AU - Beisel, Claudia
AU - Lunzen, Jan
AU - Lohse, Ansgar W
AU - Addo, Marylyn Martina
AU - Altfeld, Marcus
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2015/9
Y1 - 2015/9
N2 - Differences between women and men range from their anatomy, their natural social behavior to their susceptibility and response to different pathologies, including infectious diseases.The underlying mechanisms of sex differences in infectious diseases are manifold, including differences in exposure to common pathogens, genetic factors that modulate immune responses against pathogens and hormonal factors that may alter susceptibility or disease progression, and responsiveness to treatment. On one hand, these mechanisms lead to higher innate and adaptive immune responses in females, which result in faster clearance of acute infections and higher antibody responses to several vaccines, on the other hand this contributes to an increased susceptibility to chronic inflammatory diseases.In this review we summarize the underlying causes of sex differences in prevalence, clinical course of disease and treatment outcome of infectious diseases. In order to develop individualized treatment concepts, a fair balance between the sexes should be maintained in basic science, preclinical and clinical studies.
AB - Differences between women and men range from their anatomy, their natural social behavior to their susceptibility and response to different pathologies, including infectious diseases.The underlying mechanisms of sex differences in infectious diseases are manifold, including differences in exposure to common pathogens, genetic factors that modulate immune responses against pathogens and hormonal factors that may alter susceptibility or disease progression, and responsiveness to treatment. On one hand, these mechanisms lead to higher innate and adaptive immune responses in females, which result in faster clearance of acute infections and higher antibody responses to several vaccines, on the other hand this contributes to an increased susceptibility to chronic inflammatory diseases.In this review we summarize the underlying causes of sex differences in prevalence, clinical course of disease and treatment outcome of infectious diseases. In order to develop individualized treatment concepts, a fair balance between the sexes should be maintained in basic science, preclinical and clinical studies.
U2 - 10.1055/s-0041-104246
DO - 10.1055/s-0041-104246
M3 - SCORING: Zeitschriftenaufsatz
C2 - 26360954
VL - 140
SP - 1385
EP - 1390
JO - DEUT MED WOCHENSCHR
JF - DEUT MED WOCHENSCHR
SN - 0012-0472
IS - 18
ER -