PortalPublikationenGenome-wide association study of migraine implicates a commo...

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.

Standard

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. / Anttila, Verneri; Stefansson, Hreinn; Kallela, Mikko; Todt, Unda; Terwindt, Gisela M; Calafato, M Stella; Nyholt, Dale R; Dimas, Antigone S; Freilinger, Tobias; Müller-Myhsok, Bertram; Artto, Ville; Inouye, Michael; Alakurtti, Kirsi; Kaunisto, Mari A; Hämäläinen, Eija; de Vries, Boukje; Stam, Anine H; Weller, Claudia M; Heinze, Axel; Heinze-Kuhn, Katja; Goebel, Ingrid; Borck, Guntram; Göbel, Hartmut; Steinberg, Stacy; Wolf, Christiane; Björnsson, Asgeir; Gudmundsson, Gretar; Kirchmann, Malene; Hauge, Anne; Werge, Thomas; Schoenen, Jean; Eriksson, Johan G; Hagen, Knut; Stovner, Lars; Wichmann, H-Erich; Meitinger, Thomas; Alexander, Michael; Moebus, Susanne; Schreiber, Stefan; Aulchenko, Yurii S; Breteler, Monique M B; Uitterlinden, Andre G; Hofman, Albert; Duijn, van; Cornelia, M; Tikka-Kleemola, Päivi; Vepsäläinen, Salli; Lucae, Susanne; Tozzi, Federica; Muglia, Pierandrea; Barrett, Jeffrey; Kaprio, Jaakko; Färkkilä, Markus; Peltonen, Leena; Stefansson, Kari; Zwart, John-Anker; Ferrari, Michel D; Olesen, Jes; Daly, Mark; Wessman, Maija; Maagdenberg, van den; Kubisch, Christian; Dichgans, Martin; Dermitzakis, Emmanouil T; Frants, Rune R; Palotie, Aarno; Consortium, International Headache Genetics.

in: NAT GENET, Jahrgang 42, Nr. 10, 10, 2010, S. 869-873.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Anttila, V, Stefansson, H, Kallela, M, Todt, U, Terwindt, GM, Calafato, MS, Nyholt, DR, Dimas, AS, Freilinger, T, Müller-Myhsok, B, Artto, V, Inouye, M, Alakurtti, K, Kaunisto, MA, Hämäläinen, E, de Vries, B, Stam, AH, Weller, CM, Heinze, A, Heinze-Kuhn, K, Goebel, I, Borck, G, Göbel, H, Steinberg, S, Wolf, C, Björnsson, A, Gudmundsson, G, Kirchmann, M, Hauge, A, Werge, T, Schoenen, J, Eriksson, JG, Hagen, K, Stovner, L, Wichmann, H-E, Meitinger, T, Alexander, M, Moebus, S, Schreiber, S, Aulchenko, YS, Breteler, MMB, Uitterlinden, AG, Hofman, A, Duijn, V, Cornelia, M, Tikka-Kleemola, P, Vepsäläinen, S, Lucae, S, Tozzi, F, Muglia, P, Barrett, J, Kaprio, J, Färkkilä, M, Peltonen, L, Stefansson, K, Zwart, J-A, Ferrari, MD, Olesen, J, Daly, M, Wessman, M, Maagdenberg, VD, Kubisch, C, Dichgans, M, Dermitzakis, ET, Frants, RR, Palotie, A & Consortium, IHG 2010, 'Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.', NAT GENET, Jg. 42, Nr. 10, 10, S. 869-873. <http://www.ncbi.nlm.nih.gov/pubmed/20802479?dopt=Citation>

APA

Anttila, V., Stefansson, H., Kallela, M., Todt, U., Terwindt, G. M., Calafato, M. S., Nyholt, D. R., Dimas, A. S., Freilinger, T., Müller-Myhsok, B., Artto, V., Inouye, M., Alakurtti, K., Kaunisto, M. A., Hämäläinen, E., de Vries, B., Stam, A. H., Weller, C. M., Heinze, A., ... Consortium, I. H. G. (2010). Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. NAT GENET, 42(10), 869-873. [10]. http://www.ncbi.nlm.nih.gov/pubmed/20802479?dopt=Citation

Vancouver

Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS et al. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. NAT GENET. 2010;42(10):869-873. 10.

Bibtex

@article{1145c31b13064ee68ed881ca67b447cf,
title = "Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.",
abstract = "Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 × 10??, odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 × 10?¹¹ (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 × 10??, permuted threshold for genome-wide significance 7.7 × 10??. To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine.",
keywords = "Humans, Male, Female, Genotype, Cells, Cultured, Case-Control Studies, Quantitative Trait Loci, *Genome, Human, *Genetic Predisposition to Disease, Microsatellite Repeats/*genetics, *Genome-Wide Association Study, Calcium-Binding Proteins/genetics, Antigens, Surface/genetics, Cell Adhesion Molecules/genetics, Chromosomes, Human, Pair 8/*genetics, Glutamate Carboxypeptidase II/genetics, Lymphocytes/metabolism, Migraine Disorders/*genetics, Humans, Male, Female, Genotype, Cells, Cultured, Case-Control Studies, Quantitative Trait Loci, *Genome, Human, *Genetic Predisposition to Disease, Microsatellite Repeats/*genetics, *Genome-Wide Association Study, Calcium-Binding Proteins/genetics, Antigens, Surface/genetics, Cell Adhesion Molecules/genetics, Chromosomes, Human, Pair 8/*genetics, Glutamate Carboxypeptidase II/genetics, Lymphocytes/metabolism, Migraine Disorders/*genetics",
author = "Verneri Anttila and Hreinn Stefansson and Mikko Kallela and Unda Todt and Terwindt, {Gisela M} and Calafato, {M Stella} and Nyholt, {Dale R} and Dimas, {Antigone S} and Tobias Freilinger and Bertram M{\"u}ller-Myhsok and Ville Artto and Michael Inouye and Kirsi Alakurtti and Kaunisto, {Mari A} and Eija H{\"a}m{\"a}l{\"a}inen and {de Vries}, Boukje and Stam, {Anine H} and Weller, {Claudia M} and Axel Heinze and Katja Heinze-Kuhn and Ingrid Goebel and Guntram Borck and Hartmut G{\"o}bel and Stacy Steinberg and Christiane Wolf and Asgeir Bj{\"o}rnsson and Gretar Gudmundsson and Malene Kirchmann and Anne Hauge and Thomas Werge and Jean Schoenen and Eriksson, {Johan G} and Knut Hagen and Lars Stovner and H-Erich Wichmann and Thomas Meitinger and Michael Alexander and Susanne Moebus and Stefan Schreiber and Aulchenko, {Yurii S} and Breteler, {Monique M B} and Uitterlinden, {Andre G} and Albert Hofman and van Duijn and M Cornelia and P{\"a}ivi Tikka-Kleemola and Salli Veps{\"a}l{\"a}inen and Susanne Lucae and Federica Tozzi and Pierandrea Muglia and Jeffrey Barrett and Jaakko Kaprio and Markus F{\"a}rkkil{\"a} and Leena Peltonen and Kari Stefansson and John-Anker Zwart and Ferrari, {Michel D} and Jes Olesen and Mark Daly and Maija Wessman and Maagdenberg, {van den} and Christian Kubisch and Martin Dichgans and Dermitzakis, {Emmanouil T} and Frants, {Rune R} and Aarno Palotie and Consortium, {International Headache Genetics}",
year = "2010",
language = "English",
volume = "42",
pages = "869--873",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.

AU - Anttila, Verneri

AU - Stefansson, Hreinn

AU - Kallela, Mikko

AU - Todt, Unda

AU - Terwindt, Gisela M

AU - Calafato, M Stella

AU - Nyholt, Dale R

AU - Dimas, Antigone S

AU - Freilinger, Tobias

AU - Müller-Myhsok, Bertram

AU - Artto, Ville

AU - Inouye, Michael

AU - Alakurtti, Kirsi

AU - Kaunisto, Mari A

AU - Hämäläinen, Eija

AU - de Vries, Boukje

AU - Stam, Anine H

AU - Weller, Claudia M

AU - Heinze, Axel

AU - Heinze-Kuhn, Katja

AU - Goebel, Ingrid

AU - Borck, Guntram

AU - Göbel, Hartmut

AU - Steinberg, Stacy

AU - Wolf, Christiane

AU - Björnsson, Asgeir

AU - Gudmundsson, Gretar

AU - Kirchmann, Malene

AU - Hauge, Anne

AU - Werge, Thomas

AU - Schoenen, Jean

AU - Eriksson, Johan G

AU - Hagen, Knut

AU - Stovner, Lars

AU - Wichmann, H-Erich

AU - Meitinger, Thomas

AU - Alexander, Michael

AU - Moebus, Susanne

AU - Schreiber, Stefan

AU - Aulchenko, Yurii S

AU - Breteler, Monique M B

AU - Uitterlinden, Andre G

AU - Hofman, Albert

AU - Duijn, van

AU - Cornelia, M

AU - Tikka-Kleemola, Päivi

AU - Vepsäläinen, Salli

AU - Lucae, Susanne

AU - Tozzi, Federica

AU - Muglia, Pierandrea

AU - Barrett, Jeffrey

AU - Kaprio, Jaakko

AU - Färkkilä, Markus

AU - Peltonen, Leena

AU - Stefansson, Kari

AU - Zwart, John-Anker

AU - Ferrari, Michel D

AU - Olesen, Jes

AU - Daly, Mark

AU - Wessman, Maija

AU - Maagdenberg, van den

AU - Kubisch, Christian

AU - Dichgans, Martin

AU - Dermitzakis, Emmanouil T

AU - Frants, Rune R

AU - Palotie, Aarno

AU - Consortium, International Headache Genetics

PY - 2010

Y1 - 2010

N2 - Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 × 10??, odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 × 10?¹¹ (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 × 10??, permuted threshold for genome-wide significance 7.7 × 10??. To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine.

AB - Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 × 10??, odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 × 10?¹¹ (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 × 10??, permuted threshold for genome-wide significance 7.7 × 10??. To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine.

KW - Humans

KW - Male

KW - Female

KW - Genotype

KW - Cells, Cultured

KW - Case-Control Studies

KW - Quantitative Trait Loci

KW - Genome, Human

KW - Genetic Predisposition to Disease

KW - Microsatellite Repeats/genetics

KW - Genome-Wide Association Study

KW - Calcium-Binding Proteins/genetics

KW - Antigens, Surface/genetics

KW - Cell Adhesion Molecules/genetics

KW - Chromosomes, Human, Pair 8/genetics

KW - Glutamate Carboxypeptidase II/genetics

KW - Lymphocytes/metabolism

KW - Migraine Disorders/genetics

KW - Humans

KW - Male

KW - Female

KW - Genotype

KW - Cells, Cultured

KW - Case-Control Studies

KW - Quantitative Trait Loci

KW - Genome, Human

KW - Genetic Predisposition to Disease

KW - Microsatellite Repeats/genetics

KW - Genome-Wide Association Study

KW - Calcium-Binding Proteins/genetics

KW - Antigens, Surface/genetics

KW - Cell Adhesion Molecules/genetics

KW - Chromosomes, Human, Pair 8/genetics

KW - Glutamate Carboxypeptidase II/genetics

KW - Lymphocytes/metabolism

KW - Migraine Disorders/genetics

M3 - SCORING: Journal article

VL - 42

SP - 869

EP - 873

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 10

M1 - 10

ER -