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Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.

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Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. / Grabe, Hans Jörgen; Schwahn, Christian; Mahler, Jessie; Appel, Katja; Schulz, Andrea; Spitzer, Carsten; Fenske, Kristin; Barnow, Sven; Freyberger, Harald Jürgen; Teumer, Alexander; Petersmann, Astrid; Biffar, Reiner; Rosskopf, Dieter; John, Ulrich; Völzke, Henry.

in: PROG NEURO-PSYCHOPH, Jahrgang 36, Nr. 2, 2, 2012, S. 264-270.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Grabe, HJ, Schwahn, C, Mahler, J, Appel, K, Schulz, A, Spitzer, C, Fenske, K, Barnow, S, Freyberger, HJ, Teumer, A, Petersmann, A, Biffar, R, Rosskopf, D, John, U & Völzke, H 2012, 'Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.', PROG NEURO-PSYCHOPH, Jg. 36, Nr. 2, 2, S. 264-270. <http://www.ncbi.nlm.nih.gov/pubmed/21996278?dopt=Citation>

APA

Grabe, H. J., Schwahn, C., Mahler, J., Appel, K., Schulz, A., Spitzer, C., Fenske, K., Barnow, S., Freyberger, H. J., Teumer, A., Petersmann, A., Biffar, R., Rosskopf, D., John, U., & Völzke, H. (2012). Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. PROG NEURO-PSYCHOPH, 36(2), 264-270. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21996278?dopt=Citation

Vancouver

Grabe HJ, Schwahn C, Mahler J, Appel K, Schulz A, Spitzer C et al. Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. PROG NEURO-PSYCHOPH. 2012;36(2):264-270. 2.

Bibtex

@article{dd9dc0a4e0d14cc3a84a96377ead7629,
title = "Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.",
abstract = "Based on biological interactions between the serotonergic system and the brain-derived neurotrophic factor (BDNF), BDNF is a plausible candidate for a gene-gene-environment interaction moderating the interaction between the s/l- promoter polymorphism of the serotonin transporter (5-HTTLPR) and childhood abuse. We tested the hypothesis of a three-way interaction with respect to depressive symptoms.",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Child, Genotype, Alleles, Sex Characteristics, Promoter Regions, Genetic/*genetics, European Continental Ancestry Group/genetics, Psychiatric Status Rating Scales/statistics & numerical data, Child Abuse/*psychology, Serotonin Plasma Membrane Transport Proteins/*genetics, Genetic Predisposition to Disease/genetics, Brain-Derived Neurotrophic Factor/*genetics, Depressive Disorder/complications/*genetics/psychology, Epistasis, Genetic/*genetics, Gene-Environment Interaction, *Polymorphism, Genetic/genetics, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Child, Genotype, Alleles, Sex Characteristics, Promoter Regions, Genetic/*genetics, European Continental Ancestry Group/genetics, Psychiatric Status Rating Scales/statistics & numerical data, Child Abuse/*psychology, Serotonin Plasma Membrane Transport Proteins/*genetics, Genetic Predisposition to Disease/genetics, Brain-Derived Neurotrophic Factor/*genetics, Depressive Disorder/complications/*genetics/psychology, Epistasis, Genetic/*genetics, Gene-Environment Interaction, *Polymorphism, Genetic/genetics",
author = "Grabe, {Hans J{\"o}rgen} and Christian Schwahn and Jessie Mahler and Katja Appel and Andrea Schulz and Carsten Spitzer and Kristin Fenske and Sven Barnow and Freyberger, {Harald J{\"u}rgen} and Alexander Teumer and Astrid Petersmann and Reiner Biffar and Dieter Rosskopf and Ulrich John and Henry V{\"o}lzke",
year = "2012",
language = "English",
volume = "36",
pages = "264--270",
journal = "PROG NEURO-PSYCHOPH",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.

AU - Grabe, Hans Jörgen

AU - Schwahn, Christian

AU - Mahler, Jessie

AU - Appel, Katja

AU - Schulz, Andrea

AU - Spitzer, Carsten

AU - Fenske, Kristin

AU - Barnow, Sven

AU - Freyberger, Harald Jürgen

AU - Teumer, Alexander

AU - Petersmann, Astrid

AU - Biffar, Reiner

AU - Rosskopf, Dieter

AU - John, Ulrich

AU - Völzke, Henry

PY - 2012

Y1 - 2012

N2 - Based on biological interactions between the serotonergic system and the brain-derived neurotrophic factor (BDNF), BDNF is a plausible candidate for a gene-gene-environment interaction moderating the interaction between the s/l- promoter polymorphism of the serotonin transporter (5-HTTLPR) and childhood abuse. We tested the hypothesis of a three-way interaction with respect to depressive symptoms.

AB - Based on biological interactions between the serotonergic system and the brain-derived neurotrophic factor (BDNF), BDNF is a plausible candidate for a gene-gene-environment interaction moderating the interaction between the s/l- promoter polymorphism of the serotonin transporter (5-HTTLPR) and childhood abuse. We tested the hypothesis of a three-way interaction with respect to depressive symptoms.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Child

KW - Genotype

KW - Alleles

KW - Sex Characteristics

KW - Promoter Regions, Genetic/genetics

KW - European Continental Ancestry Group/genetics

KW - Psychiatric Status Rating Scales/statistics & numerical data

KW - Child Abuse/psychology

KW - Serotonin Plasma Membrane Transport Proteins/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Brain-Derived Neurotrophic Factor/genetics

KW - Depressive Disorder/complications/genetics/psychology

KW - Epistasis, Genetic/genetics

KW - Gene-Environment Interaction

KW - Polymorphism, Genetic/genetics

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Child

KW - Genotype

KW - Alleles

KW - Sex Characteristics

KW - Promoter Regions, Genetic/genetics

KW - European Continental Ancestry Group/genetics

KW - Psychiatric Status Rating Scales/statistics & numerical data

KW - Child Abuse/psychology

KW - Serotonin Plasma Membrane Transport Proteins/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Brain-Derived Neurotrophic Factor/genetics

KW - Depressive Disorder/complications/genetics/psychology

KW - Epistasis, Genetic/genetics

KW - Gene-Environment Interaction

KW - Polymorphism, Genetic/genetics

M3 - SCORING: Journal article

VL - 36

SP - 264

EP - 270

JO - PROG NEURO-PSYCHOPH

JF - PROG NEURO-PSYCHOPH

SN - 0278-5846

IS - 2

M1 - 2

ER -