PortalPublikationenGenetic epistasis between the brain-derived neurotrophic fac...

Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.

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  • Hans Jörgen Grabe
  • Christian Schwahn
  • Jessie Mahler
  • Katja Appel
  • Andrea Schulz
  • Carsten Spitzer
  • Kristin Fenske
  • Sven Barnow
  • Harald Jürgen Freyberger
  • Alexander Teumer
  • Astrid Petersmann
  • Reiner Biffar
  • Dieter Rosskopf
  • Ulrich John
  • Henry Völzke

Beteiligte Einrichtungen

Abstract

Based on biological interactions between the serotonergic system and the brain-derived neurotrophic factor (BDNF), BDNF is a plausible candidate for a gene-gene-environment interaction moderating the interaction between the s/l- promoter polymorphism of the serotonin transporter (5-HTTLPR) and childhood abuse. We tested the hypothesis of a three-way interaction with respect to depressive symptoms.

Bibliografische Daten

OriginalspracheEnglisch
Aufsatznummer2
ISSN0278-5846
StatusVeröffentlicht - 2012
pubmed 21996278