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Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review

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Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review. / Engel, Bastian; Laschtowitz, Alena; Janik, Maciej K; Junge, Norman; Baumann, Ulrich; Milkiewicz, Piotr; Taubert, Richard; Sebode, Marcial.

in: EUR J MED GENET, Jahrgang 64, Nr. 6, 06.2021, S. 104214.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Engel, B, Laschtowitz, A, Janik, MK, Junge, N, Baumann, U, Milkiewicz, P, Taubert, R & Sebode, M 2021, 'Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review', EUR J MED GENET, Jg. 64, Nr. 6, S. 104214. https://doi.org/10.1016/j.ejmg.2021.104214

APA

Engel, B., Laschtowitz, A., Janik, M. K., Junge, N., Baumann, U., Milkiewicz, P., Taubert, R., & Sebode, M. (2021). Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review. EUR J MED GENET, 64(6), 104214. https://doi.org/10.1016/j.ejmg.2021.104214

Vancouver

Engel B, Laschtowitz A, Janik MK, Junge N, Baumann U, Milkiewicz P et al. Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review. EUR J MED GENET. 2021 Jun;64(6):104214. https://doi.org/10.1016/j.ejmg.2021.104214

Bibtex

@article{5ad2f514226f4efd831706a9460c0892,
title = "Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review",
abstract = "Autoimmune Hepatitis (AIH) is a heterogenous, mostly chronic liver disease that affects people of all age groups, women more often than men. The aim of therapy is to prevent cirrhosis, as it mainly accounts for liver-related mortality in patients with AIH. Rates of remission are high in patients with AIH, but life-long immunosuppressive therapy is required. AIH is hypothesized to originate from immunologic reactivity targeted against mostly unknown self-antigens, potentially triggered by viral infections among other factors. While AIH does not follow a Mendelian inheritance pattern, part of the risk of developing AIH or worse disease course, is attributed to specific genetic risk factors. Major associations for the risk of development of AIH were found for HLA-DRB1*03:01 and HLA-DRB1*04:01 in adult AIH in the only genome-wide association study on AIH. However, other potential risk loci in SH2B3, CARD10 and KIR genes were described. This review covers the current knowledge on genetic risk factors in adult and pediatric AIH.",
author = "Bastian Engel and Alena Laschtowitz and Janik, {Maciej K} and Norman Junge and Ulrich Baumann and Piotr Milkiewicz and Richard Taubert and Marcial Sebode",
note = "Copyright {\textcopyright} 2021 Elsevier Masson SAS. All rights reserved.",
year = "2021",
month = jun,
doi = "10.1016/j.ejmg.2021.104214",
language = "English",
volume = "64",
pages = "104214",
journal = "EUR J MED GENET",
issn = "1769-7212",
publisher = "Elsevier Masson SAS",
number = "6",

}

RIS

TY - JOUR

T1 - Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review

AU - Engel, Bastian

AU - Laschtowitz, Alena

AU - Janik, Maciej K

AU - Junge, Norman

AU - Baumann, Ulrich

AU - Milkiewicz, Piotr

AU - Taubert, Richard

AU - Sebode, Marcial

N1 - Copyright © 2021 Elsevier Masson SAS. All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - Autoimmune Hepatitis (AIH) is a heterogenous, mostly chronic liver disease that affects people of all age groups, women more often than men. The aim of therapy is to prevent cirrhosis, as it mainly accounts for liver-related mortality in patients with AIH. Rates of remission are high in patients with AIH, but life-long immunosuppressive therapy is required. AIH is hypothesized to originate from immunologic reactivity targeted against mostly unknown self-antigens, potentially triggered by viral infections among other factors. While AIH does not follow a Mendelian inheritance pattern, part of the risk of developing AIH or worse disease course, is attributed to specific genetic risk factors. Major associations for the risk of development of AIH were found for HLA-DRB1*03:01 and HLA-DRB1*04:01 in adult AIH in the only genome-wide association study on AIH. However, other potential risk loci in SH2B3, CARD10 and KIR genes were described. This review covers the current knowledge on genetic risk factors in adult and pediatric AIH.

AB - Autoimmune Hepatitis (AIH) is a heterogenous, mostly chronic liver disease that affects people of all age groups, women more often than men. The aim of therapy is to prevent cirrhosis, as it mainly accounts for liver-related mortality in patients with AIH. Rates of remission are high in patients with AIH, but life-long immunosuppressive therapy is required. AIH is hypothesized to originate from immunologic reactivity targeted against mostly unknown self-antigens, potentially triggered by viral infections among other factors. While AIH does not follow a Mendelian inheritance pattern, part of the risk of developing AIH or worse disease course, is attributed to specific genetic risk factors. Major associations for the risk of development of AIH were found for HLA-DRB1*03:01 and HLA-DRB1*04:01 in adult AIH in the only genome-wide association study on AIH. However, other potential risk loci in SH2B3, CARD10 and KIR genes were described. This review covers the current knowledge on genetic risk factors in adult and pediatric AIH.

U2 - 10.1016/j.ejmg.2021.104214

DO - 10.1016/j.ejmg.2021.104214

M3 - SCORING: Review article

C2 - 33812046

VL - 64

SP - 104214

JO - EUR J MED GENET

JF - EUR J MED GENET

SN - 1769-7212

IS - 6

ER -