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Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma

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Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma : an analysis of the multicenter CORONA database. / May, Matthias; Aziz, Atiqullah; Zigeuner, Richard; Chromecki, Thomas; Cindolo, Luca; Schips, Luigi; De Cobelli, Ottavio; Rocco, Bernardo; De Nunzio, Cosimo; Tubaro, Andrea; Coman, Ioman; Truss, Michael; Dalpiaz, Orietta; Hoschke, Bernd; Gilfrich, Christian; Feciche, Bogdan; Stoltze, Anette; Fenske, Fabian; Fritsche, Hans-Martin; Figenshau, Robert S; Madison, Kerry; Sánchez-Chapado, Manuel; Martin, Maria Del Carmen Santiago; Salzano, Luigi; Lotrecchiano, Giuseppe; Joniau, Steven; Waidelich, Raphaela; Stief, Christian; Brookman-May, Sabine; Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group.

in: WORLD J UROL, Jahrgang 31, Nr. 5, 01.10.2013, S. 1073-80.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

May, M, Aziz, A, Zigeuner, R, Chromecki, T, Cindolo, L, Schips, L, De Cobelli, O, Rocco, B, De Nunzio, C, Tubaro, A, Coman, I, Truss, M, Dalpiaz, O, Hoschke, B, Gilfrich, C, Feciche, B, Stoltze, A, Fenske, F, Fritsche, H-M, Figenshau, RS, Madison, K, Sánchez-Chapado, M, Martin, MDCS, Salzano, L, Lotrecchiano, G, Joniau, S, Waidelich, R, Stief, C, Brookman-May, S & Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group 2013, 'Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database', WORLD J UROL, Jg. 31, Nr. 5, S. 1073-80. https://doi.org/10.1007/s00345-013-1071-x

APA

May, M., Aziz, A., Zigeuner, R., Chromecki, T., Cindolo, L., Schips, L., De Cobelli, O., Rocco, B., De Nunzio, C., Tubaro, A., Coman, I., Truss, M., Dalpiaz, O., Hoschke, B., Gilfrich, C., Feciche, B., Stoltze, A., Fenske, F., Fritsche, H-M., ... Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group (2013). Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database. WORLD J UROL, 31(5), 1073-80. https://doi.org/10.1007/s00345-013-1071-x

Vancouver

May M, Aziz A, Zigeuner R, Chromecki T, Cindolo L, Schips L et al. Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database. WORLD J UROL. 2013 Okt 1;31(5):1073-80. https://doi.org/10.1007/s00345-013-1071-x

Bibtex

@article{4a09c0ac39b84c1184f96127277c8dff,
title = "Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database",
abstract = "PURPOSE: To investigate gender differences in clinicopathological features and to analyze the prognostic impact of gender in renal cell carcinoma (RCC) patients undergoing surgery.METHODS: A total of 6,234 patients (eleven centers; Europe and USA) treated by radical or partial nephrectomy were included in this retrospective study (median follow-up 59 months; IQR 30-106). Gender differences in clinicopathological parameters were assessed. Multivariable Cox regression models were applied to determine the influence of parameters on disease-specific survival (DSS) and overall survival (OS).RESULTS: A total of 3,751 patients of the study group were male patients (60.2 %), who were significantly younger at diagnosis and received more frequently NSS than women. Significantly, more often high-grade tumors and simultaneous metastasis were present in men. Whereas tumor size and pTN stages did not differ between genders, clear-cell and chromophobe RCC was diagnosed less frequently, but papillary RCC more often in men. Gender also independently influenced DSS (HR 0.75, p < 0.001) and OS (HR 0.80, p < 0.001) with a benefit for women. However, inclusion of gender in multivariable models did not significantly gain predictive accuracies (PA) for DSS (0.868-0.870, p = 0.628) and OS (0.775-0.777, p = 0.522). Furthermore, no significantly different DSS and OS rates were found in patients undergoing NSS.CONCLUSIONS: This study demonstrates important gender differences in clinicopathological features and outcome of RCC patients with improved DSS and OS for women compared to men, even if solely patients with clear-cell RCC or M0-stage are taken into evaluation. However, inclusion of gender in multivariable models does not significantly gain PA of multivariable models.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Carcinoma, Renal Cell, Europe, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Kidney Neoplasms, Male, Middle Aged, Nephrectomy, Prognosis, Regression Analysis, Retrospective Studies, Survival Rate, Treatment Outcome",
author = "Matthias May and Atiqullah Aziz and Richard Zigeuner and Thomas Chromecki and Luca Cindolo and Luigi Schips and {De Cobelli}, Ottavio and Bernardo Rocco and {De Nunzio}, Cosimo and Andrea Tubaro and Ioman Coman and Michael Truss and Orietta Dalpiaz and Bernd Hoschke and Christian Gilfrich and Bogdan Feciche and Anette Stoltze and Fabian Fenske and Hans-Martin Fritsche and Figenshau, {Robert S} and Kerry Madison and Manuel S{\'a}nchez-Chapado and Martin, {Maria Del Carmen Santiago} and Luigi Salzano and Giuseppe Lotrecchiano and Steven Joniau and Raphaela Waidelich and Christian Stief and Sabine Brookman-May and {Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group}",
year = "2013",
month = oct,
day = "1",
doi = "10.1007/s00345-013-1071-x",
language = "English",
volume = "31",
pages = "1073--80",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma

T2 - an analysis of the multicenter CORONA database

AU - May, Matthias

AU - Aziz, Atiqullah

AU - Zigeuner, Richard

AU - Chromecki, Thomas

AU - Cindolo, Luca

AU - Schips, Luigi

AU - De Cobelli, Ottavio

AU - Rocco, Bernardo

AU - De Nunzio, Cosimo

AU - Tubaro, Andrea

AU - Coman, Ioman

AU - Truss, Michael

AU - Dalpiaz, Orietta

AU - Hoschke, Bernd

AU - Gilfrich, Christian

AU - Feciche, Bogdan

AU - Stoltze, Anette

AU - Fenske, Fabian

AU - Fritsche, Hans-Martin

AU - Figenshau, Robert S

AU - Madison, Kerry

AU - Sánchez-Chapado, Manuel

AU - Martin, Maria Del Carmen Santiago

AU - Salzano, Luigi

AU - Lotrecchiano, Giuseppe

AU - Joniau, Steven

AU - Waidelich, Raphaela

AU - Stief, Christian

AU - Brookman-May, Sabine

AU - Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group

PY - 2013/10/1

Y1 - 2013/10/1

N2 - PURPOSE: To investigate gender differences in clinicopathological features and to analyze the prognostic impact of gender in renal cell carcinoma (RCC) patients undergoing surgery.METHODS: A total of 6,234 patients (eleven centers; Europe and USA) treated by radical or partial nephrectomy were included in this retrospective study (median follow-up 59 months; IQR 30-106). Gender differences in clinicopathological parameters were assessed. Multivariable Cox regression models were applied to determine the influence of parameters on disease-specific survival (DSS) and overall survival (OS).RESULTS: A total of 3,751 patients of the study group were male patients (60.2 %), who were significantly younger at diagnosis and received more frequently NSS than women. Significantly, more often high-grade tumors and simultaneous metastasis were present in men. Whereas tumor size and pTN stages did not differ between genders, clear-cell and chromophobe RCC was diagnosed less frequently, but papillary RCC more often in men. Gender also independently influenced DSS (HR 0.75, p < 0.001) and OS (HR 0.80, p < 0.001) with a benefit for women. However, inclusion of gender in multivariable models did not significantly gain predictive accuracies (PA) for DSS (0.868-0.870, p = 0.628) and OS (0.775-0.777, p = 0.522). Furthermore, no significantly different DSS and OS rates were found in patients undergoing NSS.CONCLUSIONS: This study demonstrates important gender differences in clinicopathological features and outcome of RCC patients with improved DSS and OS for women compared to men, even if solely patients with clear-cell RCC or M0-stage are taken into evaluation. However, inclusion of gender in multivariable models does not significantly gain PA of multivariable models.

AB - PURPOSE: To investigate gender differences in clinicopathological features and to analyze the prognostic impact of gender in renal cell carcinoma (RCC) patients undergoing surgery.METHODS: A total of 6,234 patients (eleven centers; Europe and USA) treated by radical or partial nephrectomy were included in this retrospective study (median follow-up 59 months; IQR 30-106). Gender differences in clinicopathological parameters were assessed. Multivariable Cox regression models were applied to determine the influence of parameters on disease-specific survival (DSS) and overall survival (OS).RESULTS: A total of 3,751 patients of the study group were male patients (60.2 %), who were significantly younger at diagnosis and received more frequently NSS than women. Significantly, more often high-grade tumors and simultaneous metastasis were present in men. Whereas tumor size and pTN stages did not differ between genders, clear-cell and chromophobe RCC was diagnosed less frequently, but papillary RCC more often in men. Gender also independently influenced DSS (HR 0.75, p < 0.001) and OS (HR 0.80, p < 0.001) with a benefit for women. However, inclusion of gender in multivariable models did not significantly gain predictive accuracies (PA) for DSS (0.868-0.870, p = 0.628) and OS (0.775-0.777, p = 0.522). Furthermore, no significantly different DSS and OS rates were found in patients undergoing NSS.CONCLUSIONS: This study demonstrates important gender differences in clinicopathological features and outcome of RCC patients with improved DSS and OS for women compared to men, even if solely patients with clear-cell RCC or M0-stage are taken into evaluation. However, inclusion of gender in multivariable models does not significantly gain PA of multivariable models.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Renal Cell

KW - Europe

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Kaplan-Meier Estimate

KW - Kidney Neoplasms

KW - Male

KW - Middle Aged

KW - Nephrectomy

KW - Prognosis

KW - Regression Analysis

KW - Retrospective Studies

KW - Survival Rate

KW - Treatment Outcome

U2 - 10.1007/s00345-013-1071-x

DO - 10.1007/s00345-013-1071-x

M3 - SCORING: Journal article

C2 - 23568445

VL - 31

SP - 1073

EP - 1080

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 5

ER -