Formation of COPI-coated vesicles at a glance
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Formation of COPI-coated vesicles at a glance. / Arakel, Eric C; Schwappach, Blanche.
in: J CELL SCI, Jahrgang 131, Nr. 5, 13.03.2018.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Formation of COPI-coated vesicles at a glance
AU - Arakel, Eric C
AU - Schwappach, Blanche
N1 - © 2018. Published by The Company of Biologists Ltd.
PY - 2018/3/13
Y1 - 2018/3/13
N2 - The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the identity of the early secretory pathway and impinges on key cellular processes, such as protein quality control. In this Cell Science at a Glance and accompanying poster, we illustrate the different stages of COPI-coated vesicle formation and revisit decades of research in the context of recent advances in the elucidation of COPI coat structure. By calling attention to an array of questions that have remained unresolved, this review attempts to refocus the perspectives of the field.
AB - The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the identity of the early secretory pathway and impinges on key cellular processes, such as protein quality control. In this Cell Science at a Glance and accompanying poster, we illustrate the different stages of COPI-coated vesicle formation and revisit decades of research in the context of recent advances in the elucidation of COPI coat structure. By calling attention to an array of questions that have remained unresolved, this review attempts to refocus the perspectives of the field.
KW - Animals
KW - COP-Coated Vesicles/genetics
KW - Coat Protein Complex I/genetics
KW - Endoplasmic Reticulum/genetics
KW - Golgi Apparatus/genetics
KW - Humans
KW - Protein Transport/genetics
U2 - 10.1242/jcs.209890
DO - 10.1242/jcs.209890
M3 - SCORING: Review article
C2 - 29535154
VL - 131
JO - J CELL SCI
JF - J CELL SCI
SN - 0021-9533
IS - 5
ER -