Feasibility of 11C-acetate PET/CT for imaging of fatty acid synthesis in the atherosclerotic vessel wall.
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Feasibility of 11C-acetate PET/CT for imaging of fatty acid synthesis in the atherosclerotic vessel wall. / Derlin, Thorsten; Habermann, Christian; Lengyel, Zsolt; Busch, Jasmin Desiree; Wisotzki, Christian; Mester, Janos; Pávics, László.
in: J NUCL MED, Jahrgang 52, Nr. 12, 12, 2011, S. 1848-1854.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Feasibility of 11C-acetate PET/CT for imaging of fatty acid synthesis in the atherosclerotic vessel wall.
AU - Derlin, Thorsten
AU - Habermann, Christian
AU - Lengyel, Zsolt
AU - Busch, Jasmin Desiree
AU - Wisotzki, Christian
AU - Mester, Janos
AU - Pávics, László
PY - 2011
Y1 - 2011
N2 - Fatty acids are a common constituent of atherosclerotic plaque and may be synthesized in the plaque itself. Fatty acid synthesis requires acetyl-coenzyme-A (CoA) as a main substrate, which is produced from acetate. Currently, (11)C-acetate PET/CT is used for the evaluation of malignancies. There are no data concerning its potential for the characterization of atherosclerotic plaque. Therefore, the purpose of the present study was to examine the prevalence, distribution, and topographic relationship of arterial (11)C-acetate uptake and vascular calcification in major arteries.
AB - Fatty acids are a common constituent of atherosclerotic plaque and may be synthesized in the plaque itself. Fatty acid synthesis requires acetyl-coenzyme-A (CoA) as a main substrate, which is produced from acetate. Currently, (11)C-acetate PET/CT is used for the evaluation of malignancies. There are no data concerning its potential for the characterization of atherosclerotic plaque. Therefore, the purpose of the present study was to examine the prevalence, distribution, and topographic relationship of arterial (11)C-acetate uptake and vascular calcification in major arteries.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Risk Factors
KW - Cohort Studies
KW - Reproducibility of Results
KW - Feasibility Studies
KW - Biological Transport
KW - Acetates/diagnostic use/metabolism
KW - Arteries/metabolism
KW - Atherosclerosis/complications/metabolism/radionuclide imaging
KW - Calcinosis/complications/radionuclide imaging
KW - Carbon Radioisotopes/diagnostic use
KW - Fatty Acids/biosynthesis
KW - Plaque, Atherosclerotic/metabolism/radionuclide imaging
KW - Positron-Emission Tomography and Computed Tomography/methods
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Risk Factors
KW - Cohort Studies
KW - Reproducibility of Results
KW - Feasibility Studies
KW - Biological Transport
KW - Acetates/diagnostic use/metabolism
KW - Arteries/metabolism
KW - Atherosclerosis/complications/metabolism/radionuclide imaging
KW - Calcinosis/complications/radionuclide imaging
KW - Carbon Radioisotopes/diagnostic use
KW - Fatty Acids/biosynthesis
KW - Plaque, Atherosclerotic/metabolism/radionuclide imaging
KW - Positron-Emission Tomography and Computed Tomography/methods
M3 - SCORING: Journal article
VL - 52
SP - 1848
EP - 1854
JO - J NUCL MED
JF - J NUCL MED
SN - 0161-5505
IS - 12
M1 - 12
ER -