Expression of keratins in cutaneous epithelial tumors and related disorders--distribution and clinical significance.
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Expression of keratins in cutaneous epithelial tumors and related disorders--distribution and clinical significance. / Kurokawa, Ichiro; Takahashi, Kenzo; Moll, Ingrid; Moll, Roland.
in: EXP DERMATOL, Jahrgang 20, Nr. 3, 3, 2011, S. 217-228.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Expression of keratins in cutaneous epithelial tumors and related disorders--distribution and clinical significance.
AU - Kurokawa, Ichiro
AU - Takahashi, Kenzo
AU - Moll, Ingrid
AU - Moll, Roland
PY - 2011
Y1 - 2011
N2 - Keratins are a highly diverse family of cytoskeletal proteins and important markers of epithelial cell differentiation. In this review, applying the new keratin nomenclature recently introduced, we summarize and discuss the distribution and significance of keratin patterns in cutaneous epithelial tumors in relation to the epithelial structures of normal human skin. The available literature data show that the analysis of keratin profiles broadens our understanding of the differentiation, nature and histogenetic origin of the various, highly singular epithelial tumors arising in the skin. Moreover, keratins may aid in histological diagnosis and, in certain instances, may be helpful for the recognition of tumor malignancy and aggressiveness. Furthermore, we briefly address the topic of keratin-related skin disorders.
AB - Keratins are a highly diverse family of cytoskeletal proteins and important markers of epithelial cell differentiation. In this review, applying the new keratin nomenclature recently introduced, we summarize and discuss the distribution and significance of keratin patterns in cutaneous epithelial tumors in relation to the epithelial structures of normal human skin. The available literature data show that the analysis of keratin profiles broadens our understanding of the differentiation, nature and histogenetic origin of the various, highly singular epithelial tumors arising in the skin. Moreover, keratins may aid in histological diagnosis and, in certain instances, may be helpful for the recognition of tumor malignancy and aggressiveness. Furthermore, we briefly address the topic of keratin-related skin disorders.
KW - Animals
KW - Humans
KW - Skin/cytology/metabolism
KW - Keratins/classification/genetics/metabolism
KW - Neoplasms, Glandular and Epithelial/diagnosis/metabolism
KW - Skin Neoplasms/diagnosis/metabolism
KW - Animals
KW - Humans
KW - Skin/cytology/metabolism
KW - Keratins/classification/genetics/metabolism
KW - Neoplasms, Glandular and Epithelial/diagnosis/metabolism
KW - Skin Neoplasms/diagnosis/metabolism
M3 - SCORING: Journal article
VL - 20
SP - 217
EP - 228
JO - EXP DERMATOL
JF - EXP DERMATOL
SN - 0906-6705
IS - 3
M1 - 3
ER -