Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.
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Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth. / Gouveia, Ricardo; Schaffer, Lana; Papp, Suzanne; Grammel, Nicolas; Kandzia, Sebastian; Head, Steven R; Kleene, Ralf; Schachner, Melitta; Conradt, Harald S; Costa, Júlia.
in: Biochim Biophys Acta, Jahrgang 1820, Nr. 12, 12, 2012, S. 2007-2019.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.
AU - Gouveia, Ricardo
AU - Schaffer, Lana
AU - Papp, Suzanne
AU - Grammel, Nicolas
AU - Kandzia, Sebastian
AU - Head, Steven R
AU - Kleene, Ralf
AU - Schachner, Melitta
AU - Conradt, Harald S
AU - Costa, Júlia
PY - 2012
Y1 - 2012
N2 - Several glycan structures are functionally relevant in biological events associated with differentiation and regeneration which occur in the central nervous system. Here we have analysed the glycogene expression and glycosylation patterns during human NT2N neuron differentiation. We have further studied the impact of downregulating fucosyltransferase 9 (FUT9) on neurite outgrowth.
AB - Several glycan structures are functionally relevant in biological events associated with differentiation and regeneration which occur in the central nervous system. Here we have analysed the glycogene expression and glycosylation patterns during human NT2N neuron differentiation. We have further studied the impact of downregulating fucosyltransferase 9 (FUT9) on neurite outgrowth.
KW - Humans
KW - Cells, Cultured
KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
KW - Amino Acid Sequence
KW - Molecular Sequence Data
KW - Oligonucleotide Array Sequence Analysis
KW - Blotting, Western
KW - Immunoprecipitation
KW - Down-Regulation
KW - Cell Differentiation
KW - Glycosylation
KW - Polysaccharides/metabolism
KW - Peptide Fragments/metabolism
KW - Neurons/cytology/metabolism
KW - Antigens, CD15/genetics/metabolism
KW - Fucosyltransferases/genetics/metabolism
KW - Glycoproteins/genetics/metabolism
KW - Neural Cell Adhesion Molecules/metabolism
KW - Neurites/metabolism/pathology
KW - Peptide Mapping
KW - Sialic Acids/metabolism
KW - Humans
KW - Cells, Cultured
KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
KW - Amino Acid Sequence
KW - Molecular Sequence Data
KW - Oligonucleotide Array Sequence Analysis
KW - Blotting, Western
KW - Immunoprecipitation
KW - Down-Regulation
KW - Cell Differentiation
KW - Glycosylation
KW - Polysaccharides/metabolism
KW - Peptide Fragments/metabolism
KW - Neurons/cytology/metabolism
KW - Antigens, CD15/genetics/metabolism
KW - Fucosyltransferases/genetics/metabolism
KW - Glycoproteins/genetics/metabolism
KW - Neural Cell Adhesion Molecules/metabolism
KW - Neurites/metabolism/pathology
KW - Peptide Mapping
KW - Sialic Acids/metabolism
M3 - SCORING: Journal article
VL - 1820
SP - 2007
EP - 2019
JO - Biochim Biophys Acta
JF - Biochim Biophys Acta
SN - 0006-3002
IS - 12
M1 - 12
ER -