Experimental orthotopic tracheal transplantation: The Stanford technique
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Experimental orthotopic tracheal transplantation: The Stanford technique. / Schrepfer, Sonja; Deuse, Tobias; Hoyt, Grant; Sheikh, Ahmad Y; Hoffmann, Joerg; Reichenspurner, Hermann; Robbins, Robert C; Pelletier, Marc P.
in: MICROSURG, Jahrgang 27, Nr. 3, 2007, S. 187-189.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Experimental orthotopic tracheal transplantation: The Stanford technique
AU - Schrepfer, Sonja
AU - Deuse, Tobias
AU - Hoyt, Grant
AU - Sheikh, Ahmad Y
AU - Hoffmann, Joerg
AU - Reichenspurner, Hermann
AU - Robbins, Robert C
AU - Pelletier, Marc P
N1 - (c) 2007 Wiley-Liss, Inc.
PY - 2007
Y1 - 2007
N2 - The rat heterotopic tracheal transplantation model is widely used as an experimental model to study the development of obliterative airway disease (OAD) and to assess immunosuppressive strategies for chronic rejection. Despite its widespread application, the heterotopic transplantation model does have a number of limitations like the lack of air flow and mucociliary clearance. The present article provides a detailed description of the surgical technique for orthotopic tracheal transplantations, which may share more similarities with lung transplants in humans. The technique is easy to learn, the procedure is well tolerated by the animals, and the grafts develop OAD lesions similar to those of human obliterative bronchiolitis.
AB - The rat heterotopic tracheal transplantation model is widely used as an experimental model to study the development of obliterative airway disease (OAD) and to assess immunosuppressive strategies for chronic rejection. Despite its widespread application, the heterotopic transplantation model does have a number of limitations like the lack of air flow and mucociliary clearance. The present article provides a detailed description of the surgical technique for orthotopic tracheal transplantations, which may share more similarities with lung transplants in humans. The technique is easy to learn, the procedure is well tolerated by the animals, and the grafts develop OAD lesions similar to those of human obliterative bronchiolitis.
KW - Animals
KW - Models, Animal
KW - Rats
KW - Suture Techniques
KW - Trachea/transplantation
U2 - 10.1002/micr.20329
DO - 10.1002/micr.20329
M3 - SCORING: Journal article
C2 - 17326196
VL - 27
SP - 187
EP - 189
JO - MICROSURG
JF - MICROSURG
SN - 0738-1085
IS - 3
ER -