Exosomes and the Prion Protein: More than One Truth
Standard
Exosomes and the Prion Protein: More than One Truth. / Hartmann, Alexander; Muth, Christiane; Dabrowski, Oliver; Krasemann, Susanne; Glatzel, Markus.
in: FRONT NEUROSCI-SWITZ, Jahrgang 11, 2017, S. 194.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Exosomes and the Prion Protein: More than One Truth
AU - Hartmann, Alexander
AU - Muth, Christiane
AU - Dabrowski, Oliver
AU - Krasemann, Susanne
AU - Glatzel, Markus
PY - 2017
Y1 - 2017
N2 - Exosomes are involved in the progression of neurodegenerative diseases. The cellular prion protein (PrP(C)) is highly expressed on exosomes. In neurodegenerative diseases, PrP(C) has at least two functions: It is the substrate for the generation of pathological prion protein (PrP(Sc)), a key player in the pathophysiology of prion diseases. On the other hand, it binds neurotoxic amyloid-beta (Aß) oligomers, which are associated with initiation and progression of Alzheimer's disease (AD). This has direct consequences for the role of exosomal expressed PrP(C). In prion diseases, exosomal PrP leads to efficient dissemination of pathological prion protein, thus promoting spreading and transmission of the disease. In AD, exosomal PrP(C) can bind and detoxify Aß oligomers thus acting protective. In both scenarios, assessment of the state of PrP(C) on exosomes derived from blood or cerebrospinal fluid (CSF) may be useful for diagnostic workup of these diseases. This review sums up current knowledge of the role of exosomal PrP(C) on different aspects of Alzheimer's and prion disease.
AB - Exosomes are involved in the progression of neurodegenerative diseases. The cellular prion protein (PrP(C)) is highly expressed on exosomes. In neurodegenerative diseases, PrP(C) has at least two functions: It is the substrate for the generation of pathological prion protein (PrP(Sc)), a key player in the pathophysiology of prion diseases. On the other hand, it binds neurotoxic amyloid-beta (Aß) oligomers, which are associated with initiation and progression of Alzheimer's disease (AD). This has direct consequences for the role of exosomal expressed PrP(C). In prion diseases, exosomal PrP leads to efficient dissemination of pathological prion protein, thus promoting spreading and transmission of the disease. In AD, exosomal PrP(C) can bind and detoxify Aß oligomers thus acting protective. In both scenarios, assessment of the state of PrP(C) on exosomes derived from blood or cerebrospinal fluid (CSF) may be useful for diagnostic workup of these diseases. This review sums up current knowledge of the role of exosomal PrP(C) on different aspects of Alzheimer's and prion disease.
KW - Journal Article
KW - Review
U2 - 10.3389/fnins.2017.00194
DO - 10.3389/fnins.2017.00194
M3 - SCORING: Review article
C2 - 28469550
VL - 11
SP - 194
JO - FRONT NEUROSCI-SWITZ
JF - FRONT NEUROSCI-SWITZ
SN - 1662-453X
ER -
