Evaluation of the germline single nucleotide polymorphism rs583522 in the TNFAIP3 gene as a prognostic marker in esophageal cancer

TY - JOUR

T1 - Evaluation of the germline single nucleotide polymorphism rs583522 in the TNFAIP3 gene as a prognostic marker in esophageal cancer

AU - Ghadban, Tarik

AU - Schmidt-Yang, Magdalena

AU - Uzunoglu, Faik G

AU - Perez, Daniel R

AU - El Gammal, Alexander T

AU - Miro, Jameel T

AU - Wellner, Ulrich

AU - Pantel, Klaus

AU - Izbicki, Jakob R

AU - Vashist, Yogesh K

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/10/9

Y1 - 2015/10/9

N2 - Most esophageal cancer patients die because of disease relapse, hence an accurate prognosis of disease relapse and survival is essential. Genetic variations in cancer patients may serve as important indicators. Three genotypes (GG, AG, and AA) are displayed by the single nucleotide polymorphism (SNP) rs583522, which maps to the TNFAIP3 gene on chromosome 6. Evaluation of the potential prognostic value of the TNFAIP3-SNP in esophageal cancer (EC) was the aim of this study. A total of 158 patients underwent complete surgical resection of the esophagus for EC. None of them received any neoadjuvant or adjuvant treatment. Peripheral blood was sampled, and genomic DNA was extracted from leukocytes before each operation. Clinicopathologic parameters, tumor cell dissemination in bone marrow, and clinical outcome were correlated with the TNFAIP3-SNP. A-allele carriers showed advanced tumor stages compared with those of homozygous G-allele carriers (P <0.001). Patients with an A-allele genotype (AA or AG) were significantly more likely to experience a relapse (P =0.003). Survival analysis (log-rank test) revealed a significant difference in overall survival between the three groups (P = 0.039); however, none of the genotypes was identified as a disease stage-independent prognostic marker. In conclusion, TNFAIP3-SNP stratifies patients into different risk groups; however, it could not be identified as an independent prognostic marker.

AB - Most esophageal cancer patients die because of disease relapse, hence an accurate prognosis of disease relapse and survival is essential. Genetic variations in cancer patients may serve as important indicators. Three genotypes (GG, AG, and AA) are displayed by the single nucleotide polymorphism (SNP) rs583522, which maps to the TNFAIP3 gene on chromosome 6. Evaluation of the potential prognostic value of the TNFAIP3-SNP in esophageal cancer (EC) was the aim of this study. A total of 158 patients underwent complete surgical resection of the esophagus for EC. None of them received any neoadjuvant or adjuvant treatment. Peripheral blood was sampled, and genomic DNA was extracted from leukocytes before each operation. Clinicopathologic parameters, tumor cell dissemination in bone marrow, and clinical outcome were correlated with the TNFAIP3-SNP. A-allele carriers showed advanced tumor stages compared with those of homozygous G-allele carriers (P <0.001). Patients with an A-allele genotype (AA or AG) were significantly more likely to experience a relapse (P =0.003). Survival analysis (log-rank test) revealed a significant difference in overall survival between the three groups (P = 0.039); however, none of the genotypes was identified as a disease stage-independent prognostic marker. In conclusion, TNFAIP3-SNP stratifies patients into different risk groups; however, it could not be identified as an independent prognostic marker.

U2 - 10.1016/j.cancergen.2015.09.008

DO - 10.1016/j.cancergen.2015.09.008

M3 - SCORING: Journal article

C2 - 26598072

VL - 208

SP - 595

EP - 601

JO - CANCER GENET-NY

JF - CANCER GENET-NY

SN - 2210-7762

IS - 12

ER -