Estrogen and the male hippocampus: genetic variation in the aromatase gene predicting serum estrogen is associated with hippocampal gray matter volume in men
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Estrogen and the male hippocampus: genetic variation in the aromatase gene predicting serum estrogen is associated with hippocampal gray matter volume in men. / Bayer, Janine; Rune, Gabriele; Kutsche, Kerstin; Schwarze, Ulrike; Kalisch, Raffael; Büchel, Christian; Sommer-Blöchl, Tobias.
in: HIPPOCAMPUS, Jahrgang 23, Nr. 2, 01.02.2013, S. 117-21.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Estrogen and the male hippocampus: genetic variation in the aromatase gene predicting serum estrogen is associated with hippocampal gray matter volume in men
AU - Bayer, Janine
AU - Rune, Gabriele
AU - Kutsche, Kerstin
AU - Schwarze, Ulrike
AU - Kalisch, Raffael
AU - Büchel, Christian
AU - Sommer-Blöchl, Tobias
N1 - Copyright © 2012 Wiley Periodicals, Inc.
PY - 2013/2/1
Y1 - 2013/2/1
N2 - The neurosteroid 17-beta estradiol (E2) plays an important role in neuronal plasticity, neurogenesis and neuroprotection of hippocampal neurons in slice cultures and the female brain. While some effects of E2 on hippocampal neurons observed in females were also seen in the male hippocampus, others seem to be specific to females. The current study aimed to further explore the effect of E2 on the male hippocampus by investigating the relationship between genetic variations in E2 synthesis and hippocampal gray matter (GM) volume. We chose a single nucleotide polymorphism (rs700158, SNP) in the gene CYP19A1 coding for the final enzyme (aromatase) in E2 synthesis. Men homozygous for the A allele of rs700518 have repeatedly been shown to have higher E2 serum levels than male carriers of the G allele. Two independent cohorts of healthy young men were genotyped for rs700518 and voxel-based morphometry (VBM) was performed on structural magnetic resonance images to determine genotype dependent group differences. Men homozygous for the A allele of rs700518 had greater bilateral posterior hippocampal GM volumes in both cohorts. Thus, the genotype associated with higher E2 serum levels was also associated with greater hippocampal gray matter.
AB - The neurosteroid 17-beta estradiol (E2) plays an important role in neuronal plasticity, neurogenesis and neuroprotection of hippocampal neurons in slice cultures and the female brain. While some effects of E2 on hippocampal neurons observed in females were also seen in the male hippocampus, others seem to be specific to females. The current study aimed to further explore the effect of E2 on the male hippocampus by investigating the relationship between genetic variations in E2 synthesis and hippocampal gray matter (GM) volume. We chose a single nucleotide polymorphism (rs700158, SNP) in the gene CYP19A1 coding for the final enzyme (aromatase) in E2 synthesis. Men homozygous for the A allele of rs700518 have repeatedly been shown to have higher E2 serum levels than male carriers of the G allele. Two independent cohorts of healthy young men were genotyped for rs700518 and voxel-based morphometry (VBM) was performed on structural magnetic resonance images to determine genotype dependent group differences. Men homozygous for the A allele of rs700518 had greater bilateral posterior hippocampal GM volumes in both cohorts. Thus, the genotype associated with higher E2 serum levels was also associated with greater hippocampal gray matter.
KW - Adolescent
KW - Adult
KW - Aromatase
KW - Estradiol
KW - Genetic Variation
KW - Genotype
KW - Hippocampus
KW - Humans
KW - Image Interpretation, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Young Adult
U2 - 10.1002/hipo.22059
DO - 10.1002/hipo.22059
M3 - SCORING: Journal article
C2 - 22887836
VL - 23
SP - 117
EP - 121
JO - HIPPOCAMPUS
JF - HIPPOCAMPUS
SN - 1050-9631
IS - 2
ER -
