Estimating Disequilibrium Coefficients
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Estimating Disequilibrium Coefficients. / Vens, Maren; Ziegler, Andreas.
in: Methods Mol Biol, Jahrgang 1666, 2017, S. 117-132.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Estimating Disequilibrium Coefficients
AU - Vens, Maren
AU - Ziegler, Andreas
PY - 2017
Y1 - 2017
N2 - Gametic phase disequilibrium is the nonrandom association of alleles within gametes. Linkage disequilibrium (LD) describes the special case of deviation from independence between alleles at two linked genetic loci. Estimation of allelic LD requires knowledge of haplotypes. Genotype-based LD measures dispense with the haplotype estimation step and avoid bias in LD estimation. In this chapter, the most important measures for allelic and genotypic LD are introduced. The use of software packages for LD estimation is illustrated.
AB - Gametic phase disequilibrium is the nonrandom association of alleles within gametes. Linkage disequilibrium (LD) describes the special case of deviation from independence between alleles at two linked genetic loci. Estimation of allelic LD requires knowledge of haplotypes. Genotype-based LD measures dispense with the haplotype estimation step and avoid bias in LD estimation. In this chapter, the most important measures for allelic and genotypic LD are introduced. The use of software packages for LD estimation is illustrated.
KW - Journal Article
U2 - 10.1007/978-1-4939-7274-6_7
DO - 10.1007/978-1-4939-7274-6_7
M3 - SCORING: Journal article
C2 - 28980244
VL - 1666
SP - 117
EP - 132
JO - Methods Mol Biol
JF - Methods Mol Biol
SN - 1064-3745
ER -