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Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells

Standard

Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells. / Hegen, M; Mittrücker, H W; Hug, R; Demuth, H U; Neubert, K; Barth, A; Fleischer, B.

in: IMMUNOBIOLOGY, Jahrgang 189, Nr. 5, 01.12.1993, S. 483-93.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hegen, M, Mittrücker, HW, Hug, R, Demuth, HU, Neubert, K, Barth, A & Fleischer, B 1993, 'Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells', IMMUNOBIOLOGY, Jg. 189, Nr. 5, S. 483-93. https://doi.org/10.1016/S0171-2985(11)80419-5

APA

Hegen, M., Mittrücker, H. W., Hug, R., Demuth, H. U., Neubert, K., Barth, A., & Fleischer, B. (1993). Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells. IMMUNOBIOLOGY, 189(5), 483-93. https://doi.org/10.1016/S0171-2985(11)80419-5

Vancouver

Hegen M, Mittrücker HW, Hug R, Demuth HU, Neubert K, Barth A et al. Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells. IMMUNOBIOLOGY. 1993 Dez 1;189(5):483-93. https://doi.org/10.1016/S0171-2985(11)80419-5

Bibtex

@article{ccf89273279149e5bafa64e87e29628f,
title = "Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells",
abstract = "CD26 is a proteolytic enzyme (dipeptidylpeptidase IV) expressed on the T cell surface that defines an alternative activation signal for human T lymphocytes. Crosslinking of CD26 via monoclonal antibodies triggers proliferation and cytotoxicity in preactivated T cells. In this study, we used highly specific competitive and irreversible inhibitors of dipeptidylpeptidase IV to study the role of the enzymatic activity in activation of CD26-transfected T cells as well as of CD26-expressing normal human T cell clones. These inhibitors at concentrations that blocked up to 95% of the enzymatic activity, did not specifically inhibit T cell activation neither via TCR/CD3 nor via CD26 itself. This demonstrates that the enzymatic activity of CD26 is not required for its T cell activating properties.",
keywords = "Animals, Antigens, Differentiation, T-Lymphocyte, Cell Line, Cytotoxicity Tests, Immunologic, Dipeptidyl Peptidase 4, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Humans, Interleukin-2, Lymphocyte Activation, Mice, Signal Transduction, T-Lymphocytes, Tumor Cells, Cultured",
author = "M Hegen and Mittr{\"u}cker, {H W} and R Hug and Demuth, {H U} and K Neubert and A Barth and B Fleischer",
year = "1993",
month = dec,
day = "1",
doi = "10.1016/S0171-2985(11)80419-5",
language = "English",
volume = "189",
pages = "483--93",
journal = "IMMUNOBIOLOGY",
issn = "0171-2985",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "5",

}

RIS

TY - JOUR

T1 - Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells

AU - Hegen, M

AU - Mittrücker, H W

AU - Hug, R

AU - Demuth, H U

AU - Neubert, K

AU - Barth, A

AU - Fleischer, B

PY - 1993/12/1

Y1 - 1993/12/1

N2 - CD26 is a proteolytic enzyme (dipeptidylpeptidase IV) expressed on the T cell surface that defines an alternative activation signal for human T lymphocytes. Crosslinking of CD26 via monoclonal antibodies triggers proliferation and cytotoxicity in preactivated T cells. In this study, we used highly specific competitive and irreversible inhibitors of dipeptidylpeptidase IV to study the role of the enzymatic activity in activation of CD26-transfected T cells as well as of CD26-expressing normal human T cell clones. These inhibitors at concentrations that blocked up to 95% of the enzymatic activity, did not specifically inhibit T cell activation neither via TCR/CD3 nor via CD26 itself. This demonstrates that the enzymatic activity of CD26 is not required for its T cell activating properties.

AB - CD26 is a proteolytic enzyme (dipeptidylpeptidase IV) expressed on the T cell surface that defines an alternative activation signal for human T lymphocytes. Crosslinking of CD26 via monoclonal antibodies triggers proliferation and cytotoxicity in preactivated T cells. In this study, we used highly specific competitive and irreversible inhibitors of dipeptidylpeptidase IV to study the role of the enzymatic activity in activation of CD26-transfected T cells as well as of CD26-expressing normal human T cell clones. These inhibitors at concentrations that blocked up to 95% of the enzymatic activity, did not specifically inhibit T cell activation neither via TCR/CD3 nor via CD26 itself. This demonstrates that the enzymatic activity of CD26 is not required for its T cell activating properties.

KW - Animals

KW - Antigens, Differentiation, T-Lymphocyte

KW - Cell Line

KW - Cytotoxicity Tests, Immunologic

KW - Dipeptidyl Peptidase 4

KW - Dipeptidyl-Peptidases and Tripeptidyl-Peptidases

KW - Humans

KW - Interleukin-2

KW - Lymphocyte Activation

KW - Mice

KW - Signal Transduction

KW - T-Lymphocytes

KW - Tumor Cells, Cultured

U2 - 10.1016/S0171-2985(11)80419-5

DO - 10.1016/S0171-2985(11)80419-5

M3 - SCORING: Journal article

C2 - 7907318

VL - 189

SP - 483

EP - 493

JO - IMMUNOBIOLOGY

JF - IMMUNOBIOLOGY

SN - 0171-2985

IS - 5

ER -