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Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species

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Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species. / Kaehler, Jan; Sill, Bjoern; Koester, Ralf; Mittmann, Clemens; Orzechowski, Hans-Dieter; Muenzel, Thomas; Meinertz, Thomas.

in: CLIN SCI, Jahrgang 103, Nr. Suppl 48, 08.2002, S. 176S-178S.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kaehler, J, Sill, B, Koester, R, Mittmann, C, Orzechowski, H-D, Muenzel, T & Meinertz, T 2002, 'Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species', CLIN SCI, Jg. 103, Nr. Suppl 48, S. 176S-178S. https://doi.org/10.1042/CS103S176S

APA

Kaehler, J., Sill, B., Koester, R., Mittmann, C., Orzechowski, H-D., Muenzel, T., & Meinertz, T. (2002). Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species. CLIN SCI, 103(Suppl 48), 176S-178S. https://doi.org/10.1042/CS103S176S

Vancouver

Kaehler J, Sill B, Koester R, Mittmann C, Orzechowski H-D, Muenzel T et al. Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species. CLIN SCI. 2002 Aug;103(Suppl 48):176S-178S. https://doi.org/10.1042/CS103S176S

Bibtex

@article{4271ae86c3d645baa66f21db73d02a13,
title = "Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species",
abstract = "A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development of atherosclerosis. We therefore subjected cultured human umbilical vein endothelial cells and coronary artery smooth muscle cells to oxidative stress induced by xanthine oxidase or hydrogen peroxide and observed alterations in ET-1 metabolism. Incubation with oxygen-derived free radicals increased preproET-1 promoter activity, ET-1 mRNA synthesis and big ET-1 concentrations in both cell types. This interaction of oxidative stress and ET-1 expression may be relevant in atherogenic conditions such as hypercholesterolaemia and hypertension since our data indicate that oxidative stress further aggravates the injurious effects attributed to ET-1.",
keywords = "Cells, Cultured, Coronary Vessels, Endothelin-1/genetics, Endothelins/metabolism, Endothelium, Vascular/metabolism, Humans, Hydrogen Peroxide/pharmacology, Muscle, Smooth, Vascular/metabolism, Protein Precursors/metabolism, RNA, Messenger/metabolism, Reactive Oxygen Species/pharmacology, Stimulation, Chemical, Umbilical Veins, Xanthine Oxidase/pharmacology",
author = "Jan Kaehler and Bjoern Sill and Ralf Koester and Clemens Mittmann and Hans-Dieter Orzechowski and Thomas Muenzel and Thomas Meinertz",
year = "2002",
month = aug,
doi = "10.1042/CS103S176S",
language = "English",
volume = "103",
pages = "176S--178S",
journal = "CLIN SCI",
issn = "0143-5221",
publisher = "PORTLAND PRESS LTD",
number = "Suppl 48",

}

RIS

TY - JOUR

T1 - Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species

AU - Kaehler, Jan

AU - Sill, Bjoern

AU - Koester, Ralf

AU - Mittmann, Clemens

AU - Orzechowski, Hans-Dieter

AU - Muenzel, Thomas

AU - Meinertz, Thomas

PY - 2002/8

Y1 - 2002/8

N2 - A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development of atherosclerosis. We therefore subjected cultured human umbilical vein endothelial cells and coronary artery smooth muscle cells to oxidative stress induced by xanthine oxidase or hydrogen peroxide and observed alterations in ET-1 metabolism. Incubation with oxygen-derived free radicals increased preproET-1 promoter activity, ET-1 mRNA synthesis and big ET-1 concentrations in both cell types. This interaction of oxidative stress and ET-1 expression may be relevant in atherogenic conditions such as hypercholesterolaemia and hypertension since our data indicate that oxidative stress further aggravates the injurious effects attributed to ET-1.

AB - A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development of atherosclerosis. We therefore subjected cultured human umbilical vein endothelial cells and coronary artery smooth muscle cells to oxidative stress induced by xanthine oxidase or hydrogen peroxide and observed alterations in ET-1 metabolism. Incubation with oxygen-derived free radicals increased preproET-1 promoter activity, ET-1 mRNA synthesis and big ET-1 concentrations in both cell types. This interaction of oxidative stress and ET-1 expression may be relevant in atherogenic conditions such as hypercholesterolaemia and hypertension since our data indicate that oxidative stress further aggravates the injurious effects attributed to ET-1.

KW - Cells, Cultured

KW - Coronary Vessels

KW - Endothelin-1/genetics

KW - Endothelins/metabolism

KW - Endothelium, Vascular/metabolism

KW - Humans

KW - Hydrogen Peroxide/pharmacology

KW - Muscle, Smooth, Vascular/metabolism

KW - Protein Precursors/metabolism

KW - RNA, Messenger/metabolism

KW - Reactive Oxygen Species/pharmacology

KW - Stimulation, Chemical

KW - Umbilical Veins

KW - Xanthine Oxidase/pharmacology

U2 - 10.1042/CS103S176S

DO - 10.1042/CS103S176S

M3 - SCORING: Journal article

C2 - 12193080

VL - 103

SP - 176S-178S

JO - CLIN SCI

JF - CLIN SCI

SN - 0143-5221

IS - Suppl 48

ER -