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Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro

Standard

Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro. / Tiede, S; Bohm, K; Meier, N; Funk, W; Paus, R.

in: EUR J CELL BIOL, Jahrgang 89, Nr. 10, 10.2010, S. 769-77.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tiede, S, Bohm, K, Meier, N, Funk, W & Paus, R 2010, 'Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro', EUR J CELL BIOL, Jg. 89, Nr. 10, S. 769-77. https://doi.org/10.1016/j.ejcb.2010.06.002

APA

Tiede, S., Bohm, K., Meier, N., Funk, W., & Paus, R. (2010). Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro. EUR J CELL BIOL, 89(10), 769-77. https://doi.org/10.1016/j.ejcb.2010.06.002

Vancouver

Tiede S, Bohm K, Meier N, Funk W, Paus R. Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro. EUR J CELL BIOL. 2010 Okt;89(10):769-77. https://doi.org/10.1016/j.ejcb.2010.06.002

Bibtex

@article{ac6f64ee096d4dd28d76cea3079d030b,
title = "Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro",
abstract = "Here we demonstrate that physiological concentrations of the thyroid hormones T3 and T4 enhance the KERATIN 15 promoter activity and expression in epithelial stem cells of adult human scalp hair follicles in situ and in vitro. Additionally, T3 and T4 stimulate expression of the immuno-inhibitory surface molecule CD200. Subsequently, T3 and T4 induce apoptosis and differentiation and inhibit clonal growth of these progenitor cells in vitro. These data suggest that human hair follicle bulge-derived epithelial stem cells underlie profound, previously unknown hormonal regulation by thyroid hormones, and show that primary human keratin 15-GFP+ progenitor cells can be exploited to further elucidate fundamental endocrine controls of human epithelial stem cells.",
keywords = "Adult, Apoptosis, Cell Differentiation, Cell Line, Cell Proliferation, Cells, Cultured, Epithelial Cells, Hair Follicle, Humans, Keratin-15, Organ Culture Techniques, Stem Cells, Thyroxine, Triiodothyronine, Journal Article, Research Support, Non-U.S. Gov't",
author = "S Tiede and K Bohm and N Meier and W Funk and R Paus",
note = "Copyright (c) 2010 Elsevier GmbH. All rights reserved.",
year = "2010",
month = oct,
doi = "10.1016/j.ejcb.2010.06.002",
language = "English",
volume = "89",
pages = "769--77",
journal = "EUR J CELL BIOL",
issn = "0171-9335",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "10",

}

RIS

TY - JOUR

T1 - Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro

AU - Tiede, S

AU - Bohm, K

AU - Meier, N

AU - Funk, W

AU - Paus, R

N1 - Copyright (c) 2010 Elsevier GmbH. All rights reserved.

PY - 2010/10

Y1 - 2010/10

N2 - Here we demonstrate that physiological concentrations of the thyroid hormones T3 and T4 enhance the KERATIN 15 promoter activity and expression in epithelial stem cells of adult human scalp hair follicles in situ and in vitro. Additionally, T3 and T4 stimulate expression of the immuno-inhibitory surface molecule CD200. Subsequently, T3 and T4 induce apoptosis and differentiation and inhibit clonal growth of these progenitor cells in vitro. These data suggest that human hair follicle bulge-derived epithelial stem cells underlie profound, previously unknown hormonal regulation by thyroid hormones, and show that primary human keratin 15-GFP+ progenitor cells can be exploited to further elucidate fundamental endocrine controls of human epithelial stem cells.

AB - Here we demonstrate that physiological concentrations of the thyroid hormones T3 and T4 enhance the KERATIN 15 promoter activity and expression in epithelial stem cells of adult human scalp hair follicles in situ and in vitro. Additionally, T3 and T4 stimulate expression of the immuno-inhibitory surface molecule CD200. Subsequently, T3 and T4 induce apoptosis and differentiation and inhibit clonal growth of these progenitor cells in vitro. These data suggest that human hair follicle bulge-derived epithelial stem cells underlie profound, previously unknown hormonal regulation by thyroid hormones, and show that primary human keratin 15-GFP+ progenitor cells can be exploited to further elucidate fundamental endocrine controls of human epithelial stem cells.

KW - Adult

KW - Apoptosis

KW - Cell Differentiation

KW - Cell Line

KW - Cell Proliferation

KW - Cells, Cultured

KW - Epithelial Cells

KW - Hair Follicle

KW - Humans

KW - Keratin-15

KW - Organ Culture Techniques

KW - Stem Cells

KW - Thyroxine

KW - Triiodothyronine

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ejcb.2010.06.002

DO - 10.1016/j.ejcb.2010.06.002

M3 - SCORING: Journal article

C2 - 20656376

VL - 89

SP - 769

EP - 777

JO - EUR J CELL BIOL

JF - EUR J CELL BIOL

SN - 0171-9335

IS - 10

ER -