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Emergence of virus escape mutants after immunization with epitope vaccine

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Emergence of virus escape mutants after immunization with epitope vaccine. / Weidt, G; Deppert, W; Utermöhlen, O; Heukeshoven, J; Lehmann-Grube, F.

in: J VIROL, Jahrgang 69, Nr. 11, 11.1995, S. 7147-51.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Weidt, G, Deppert, W, Utermöhlen, O, Heukeshoven, J & Lehmann-Grube, F 1995, 'Emergence of virus escape mutants after immunization with epitope vaccine', J VIROL, Jg. 69, Nr. 11, S. 7147-51.

APA

Weidt, G., Deppert, W., Utermöhlen, O., Heukeshoven, J., & Lehmann-Grube, F. (1995). Emergence of virus escape mutants after immunization with epitope vaccine. J VIROL, 69(11), 7147-51.

Vancouver

Weidt G, Deppert W, Utermöhlen O, Heukeshoven J, Lehmann-Grube F. Emergence of virus escape mutants after immunization with epitope vaccine. J VIROL. 1995 Nov;69(11):7147-51.

Bibtex

@article{5dca39122d874f19a397b4192b9cfcea,
title = "Emergence of virus escape mutants after immunization with epitope vaccine",
abstract = "BALB/c and C57BL/6J mice were immunized with recombinant vaccines consisting of lymphocytic choriomeningitis virus CD8+ T-lymphocyte epitopes and a carrier protein. During challenge infection with WE strain lymphocytic choriomeningitis virus, mutants with alterations in distinct amino acid residues of the epitopic nonapeptides appeared and multiplied. Splenocytes from WE-infected BALB/c mice lysed cells coated with the WE-type epitope; lysis was considerably less effective when the epitopic nonapeptide with which the syngeneic cells had been sensitized was the mutated form. Neither target was lysed by splenocytes from BALB/c mice infected with the variant virus. Mutants were not detected in F1 hybrid mice immunized with two viral epitopes that were restricted by class I molecules of both parents.",
keywords = "Amino Acid Sequence, Animals, Base Sequence, CD8-Positive T-Lymphocytes, Capsid, DNA Primers, DNA, Complementary, DNA, Viral, Epitopes, Female, Lymphocytic choriomeningitis virus, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred Strains, Molecular Sequence Data, Mutagenesis, Polymerase Chain Reaction, Vaccines, Synthetic, Viral Core Proteins, Viral Vaccines, Journal Article, Research Support, Non-U.S. Gov't",
author = "G Weidt and W Deppert and O Uterm{\"o}hlen and J Heukeshoven and F Lehmann-Grube",
year = "1995",
month = nov,
language = "English",
volume = "69",
pages = "7147--51",
journal = "J VIROL",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "11",

}

RIS

TY - JOUR

T1 - Emergence of virus escape mutants after immunization with epitope vaccine

AU - Weidt, G

AU - Deppert, W

AU - Utermöhlen, O

AU - Heukeshoven, J

AU - Lehmann-Grube, F

PY - 1995/11

Y1 - 1995/11

N2 - BALB/c and C57BL/6J mice were immunized with recombinant vaccines consisting of lymphocytic choriomeningitis virus CD8+ T-lymphocyte epitopes and a carrier protein. During challenge infection with WE strain lymphocytic choriomeningitis virus, mutants with alterations in distinct amino acid residues of the epitopic nonapeptides appeared and multiplied. Splenocytes from WE-infected BALB/c mice lysed cells coated with the WE-type epitope; lysis was considerably less effective when the epitopic nonapeptide with which the syngeneic cells had been sensitized was the mutated form. Neither target was lysed by splenocytes from BALB/c mice infected with the variant virus. Mutants were not detected in F1 hybrid mice immunized with two viral epitopes that were restricted by class I molecules of both parents.

AB - BALB/c and C57BL/6J mice were immunized with recombinant vaccines consisting of lymphocytic choriomeningitis virus CD8+ T-lymphocyte epitopes and a carrier protein. During challenge infection with WE strain lymphocytic choriomeningitis virus, mutants with alterations in distinct amino acid residues of the epitopic nonapeptides appeared and multiplied. Splenocytes from WE-infected BALB/c mice lysed cells coated with the WE-type epitope; lysis was considerably less effective when the epitopic nonapeptide with which the syngeneic cells had been sensitized was the mutated form. Neither target was lysed by splenocytes from BALB/c mice infected with the variant virus. Mutants were not detected in F1 hybrid mice immunized with two viral epitopes that were restricted by class I molecules of both parents.

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - CD8-Positive T-Lymphocytes

KW - Capsid

KW - DNA Primers

KW - DNA, Complementary

KW - DNA, Viral

KW - Epitopes

KW - Female

KW - Lymphocytic choriomeningitis virus

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C57BL

KW - Mice, Inbred Strains

KW - Molecular Sequence Data

KW - Mutagenesis

KW - Polymerase Chain Reaction

KW - Vaccines, Synthetic

KW - Viral Core Proteins

KW - Viral Vaccines

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 7474135

VL - 69

SP - 7147

EP - 7151

JO - J VIROL

JF - J VIROL

SN - 0022-538X

IS - 11

ER -