Embolus Retriever with Interlinked Cages versus other stent retrievers in acute ischemic stroke: an observational comparative study
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Embolus Retriever with Interlinked Cages versus other stent retrievers in acute ischemic stroke: an observational comparative study. / Gruber, Philipp; Zeller, Salome; Garcia-Esperon, Carlos; Berberat, Jatta; Anon, Javier; Diepers, Michael; Nedeltchev, Krassen; Flottmann, Fabian; Fiehler, Jens; Remonda, Luca; Kahles, Timo.
in: J NEUROINTERV SURG, Jahrgang 10, Nr. 12, 12.2018, S. e31.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Embolus Retriever with Interlinked Cages versus other stent retrievers in acute ischemic stroke: an observational comparative study
AU - Gruber, Philipp
AU - Zeller, Salome
AU - Garcia-Esperon, Carlos
AU - Berberat, Jatta
AU - Anon, Javier
AU - Diepers, Michael
AU - Nedeltchev, Krassen
AU - Flottmann, Fabian
AU - Fiehler, Jens
AU - Remonda, Luca
AU - Kahles, Timo
N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2018/12
Y1 - 2018/12
N2 - BACKGROUND AND PURPOSE: Given the promising performance of the new Embolus Retriever with Interlinked Cages (ERIC) in smaller case series, we sought to assess the efficacy and safety of mechanical thrombectomy (MT) with ERIC compared with other stent retrievers (SRs) in acute ischemic stroke due to large vessel occlusion (LVO).METHODS: We reviewed the databases of two comprehensive stroke centers in in Germany and Switzerland for MT due to LVO in the anterior circulation with either ERIC or another SR as a first device. Co-primary outcome was defined as successful recanalization (Thrombolysis in Cerebral Infarction 2b/3) after the first device and favorable outcome (modified Rankin Scale score 0-2) at 90 days' follow-up. Multiple logistic regression analysis was applied to adjust for potential confounders.RESULTS: 183 consecutive patients with stroke were treated with either ERIC (49%) or a SR (51%) as the first device and successful recanalization was seen in 82% and 57%, respectively (P<0.001). Adding SR to futile ERIC recanalization or vice versa increased final recanalization rates (ERIC: 87%, SR: 79%). The use of ERIC as a first device resulted in favorable clinical outcome in 50% compared with 35% when a SR was used (P=0.038), an effect driven by age, stroke severity, presence of carotid-T-occlusion, and general anesthesia and not by the device deployed.CONCLUSION: The use of ERIC as a first device appeared to be associated with higher rates of successful recanalization and resulted in better functional outcome. However, favorable outcome was not attributable to ERIC. Most importantly, both device types complemented one another and improved final recanalization rates when used successively.
AB - BACKGROUND AND PURPOSE: Given the promising performance of the new Embolus Retriever with Interlinked Cages (ERIC) in smaller case series, we sought to assess the efficacy and safety of mechanical thrombectomy (MT) with ERIC compared with other stent retrievers (SRs) in acute ischemic stroke due to large vessel occlusion (LVO).METHODS: We reviewed the databases of two comprehensive stroke centers in in Germany and Switzerland for MT due to LVO in the anterior circulation with either ERIC or another SR as a first device. Co-primary outcome was defined as successful recanalization (Thrombolysis in Cerebral Infarction 2b/3) after the first device and favorable outcome (modified Rankin Scale score 0-2) at 90 days' follow-up. Multiple logistic regression analysis was applied to adjust for potential confounders.RESULTS: 183 consecutive patients with stroke were treated with either ERIC (49%) or a SR (51%) as the first device and successful recanalization was seen in 82% and 57%, respectively (P<0.001). Adding SR to futile ERIC recanalization or vice versa increased final recanalization rates (ERIC: 87%, SR: 79%). The use of ERIC as a first device resulted in favorable clinical outcome in 50% compared with 35% when a SR was used (P=0.038), an effect driven by age, stroke severity, presence of carotid-T-occlusion, and general anesthesia and not by the device deployed.CONCLUSION: The use of ERIC as a first device appeared to be associated with higher rates of successful recanalization and resulted in better functional outcome. However, favorable outcome was not attributable to ERIC. Most importantly, both device types complemented one another and improved final recanalization rates when used successively.
KW - Aged
KW - Aged, 80 and over
KW - Brain Ischemia
KW - Device Removal
KW - Embolism
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Retrospective Studies
KW - Stents
KW - Stroke
KW - Thrombectomy
KW - Treatment Outcome
KW - Comparative Study
KW - Journal Article
KW - Multicenter Study
KW - Observational Study
U2 - 10.1136/neurintsurg-2018-013838
DO - 10.1136/neurintsurg-2018-013838
M3 - SCORING: Journal article
C2 - 29773715
VL - 10
SP - e31
JO - J NEUROINTERV SURG
JF - J NEUROINTERV SURG
SN - 1759-8478
IS - 12
ER -