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Egfr amplification specific gene expression in phyllodes tumours of the breast.

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Egfr amplification specific gene expression in phyllodes tumours of the breast. / Agelopoulos, Konstantin; Kersting, Christian; Korsching, Eberhard; Schmidt, Hartmut; Kuijper, Arno; August, Christian; Wülfing, Pia; Tio, Joke; Boecker, Werner; Diest, van; Brandt, Burkhard; Brandt, Burkhard; Buerger, Horst.

in: MOL CELL ONCOL, Jahrgang 29, Nr. 6, 6, 2007, S. 443-451.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Agelopoulos, K, Kersting, C, Korsching, E, Schmidt, H, Kuijper, A, August, C, Wülfing, P, Tio, J, Boecker, W, Diest, V, Brandt, B, Brandt, B & Buerger, H 2007, 'Egfr amplification specific gene expression in phyllodes tumours of the breast.', MOL CELL ONCOL, Jg. 29, Nr. 6, 6, S. 443-451. https://doi.org/10.1155/2007/754712

APA

Agelopoulos, K., Kersting, C., Korsching, E., Schmidt, H., Kuijper, A., August, C., Wülfing, P., Tio, J., Boecker, W., Diest, V., Brandt, B., Brandt, B., & Buerger, H. (2007). Egfr amplification specific gene expression in phyllodes tumours of the breast. MOL CELL ONCOL, 29(6), 443-451. [6]. https://doi.org/10.1155/2007/754712

Vancouver

Agelopoulos K, Kersting C, Korsching E, Schmidt H, Kuijper A, August C et al. Egfr amplification specific gene expression in phyllodes tumours of the breast. MOL CELL ONCOL. 2007;29(6):443-451. 6. https://doi.org/10.1155/2007/754712

Bibtex

@article{4e4656cce9f9448a8aba1886cb0f31e1,
title = "Egfr amplification specific gene expression in phyllodes tumours of the breast.",
abstract = "BACKGROUND: Recently, we were able to show that amplifications of the epidermal growth factor receptor (egfr) gene and the overexpression of EGFR were associated with the initiation and progression of phyllodes tumours. METHODS: In order to gain further insights into regulation mechanisms associated with egfr amplifications and EGFR expression in phyllodes tumours, we performed global gene expression analysis (Affymetrix A133.2) on a series of 10 phyllodes tumours, of these three with and seven without amplifications of an important regulatory repeat in intron 1 of egfr (CA-SSR I). The results were verified and extended by means of immunohistochemistry using the tissue microarray method on an extensively characterized series of 58 phyllodes tumours with antibodies against caveolin-1, eps15, EGF, TGF-alpha, pErk, pAkt and mdm2. RESULTS: We were able to show that the presence of egfr CA-SSR I amplifications in phyllodes tumours was associated with 230 differentially expressed genes. Caveolin-1 and eps15, involved in EGFR turnover and signalling, were regulated differentially on the RNA and protein level proportionally to egfr gene dosage. Further immunohistochemical analysis revealed that the expression of caveolin-1 and eps15 were also significantly correlated with the expression of pAkt (p",
author = "Konstantin Agelopoulos and Christian Kersting and Eberhard Korsching and Hartmut Schmidt and Arno Kuijper and Christian August and Pia W{\"u}lfing and Joke Tio and Werner Boecker and van Diest and Burkhard Brandt and Burkhard Brandt and Horst Buerger",
year = "2007",
doi = "10.1155/2007/754712",
language = "Deutsch",
volume = "29",
pages = "443--451",
journal = "MOL CELL ONCOL",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Egfr amplification specific gene expression in phyllodes tumours of the breast.

AU - Agelopoulos, Konstantin

AU - Kersting, Christian

AU - Korsching, Eberhard

AU - Schmidt, Hartmut

AU - Kuijper, Arno

AU - August, Christian

AU - Wülfing, Pia

AU - Tio, Joke

AU - Boecker, Werner

AU - Diest, van

AU - Brandt, Burkhard

AU - Brandt, Burkhard

AU - Buerger, Horst

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Recently, we were able to show that amplifications of the epidermal growth factor receptor (egfr) gene and the overexpression of EGFR were associated with the initiation and progression of phyllodes tumours. METHODS: In order to gain further insights into regulation mechanisms associated with egfr amplifications and EGFR expression in phyllodes tumours, we performed global gene expression analysis (Affymetrix A133.2) on a series of 10 phyllodes tumours, of these three with and seven without amplifications of an important regulatory repeat in intron 1 of egfr (CA-SSR I). The results were verified and extended by means of immunohistochemistry using the tissue microarray method on an extensively characterized series of 58 phyllodes tumours with antibodies against caveolin-1, eps15, EGF, TGF-alpha, pErk, pAkt and mdm2. RESULTS: We were able to show that the presence of egfr CA-SSR I amplifications in phyllodes tumours was associated with 230 differentially expressed genes. Caveolin-1 and eps15, involved in EGFR turnover and signalling, were regulated differentially on the RNA and protein level proportionally to egfr gene dosage. Further immunohistochemical analysis revealed that the expression of caveolin-1 and eps15 were also significantly correlated with the expression of pAkt (p

AB - BACKGROUND: Recently, we were able to show that amplifications of the epidermal growth factor receptor (egfr) gene and the overexpression of EGFR were associated with the initiation and progression of phyllodes tumours. METHODS: In order to gain further insights into regulation mechanisms associated with egfr amplifications and EGFR expression in phyllodes tumours, we performed global gene expression analysis (Affymetrix A133.2) on a series of 10 phyllodes tumours, of these three with and seven without amplifications of an important regulatory repeat in intron 1 of egfr (CA-SSR I). The results were verified and extended by means of immunohistochemistry using the tissue microarray method on an extensively characterized series of 58 phyllodes tumours with antibodies against caveolin-1, eps15, EGF, TGF-alpha, pErk, pAkt and mdm2. RESULTS: We were able to show that the presence of egfr CA-SSR I amplifications in phyllodes tumours was associated with 230 differentially expressed genes. Caveolin-1 and eps15, involved in EGFR turnover and signalling, were regulated differentially on the RNA and protein level proportionally to egfr gene dosage. Further immunohistochemical analysis revealed that the expression of caveolin-1 and eps15 were also significantly correlated with the expression of pAkt (p

U2 - 10.1155/2007/754712

DO - 10.1155/2007/754712

M3 - SCORING: Zeitschriftenaufsatz

VL - 29

SP - 443

EP - 451

JO - MOL CELL ONCOL

JF - MOL CELL ONCOL

SN - 2372-3556

IS - 6

M1 - 6

ER -