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Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects.

Standard

Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects. / Hekmatara, T; Bernreuther, Christian; Khalansky, A S; Theisen, A; Weissenberger, J; Matschke, Jakob; Gelperina, S; Kreuter, J; Glatzel, Markus.

in: CLIN NEUROPATHOL, Jahrgang 28, Nr. 3, 3, 2009, S. 153-164.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hekmatara, T, Bernreuther, C, Khalansky, AS, Theisen, A, Weissenberger, J, Matschke, J, Gelperina, S, Kreuter, J & Glatzel, M 2009, 'Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects.', CLIN NEUROPATHOL, Jg. 28, Nr. 3, 3, S. 153-164. <http://www.ncbi.nlm.nih.gov/pubmed/19537130?dopt=Citation>

APA

Hekmatara, T., Bernreuther, C., Khalansky, A. S., Theisen, A., Weissenberger, J., Matschke, J., Gelperina, S., Kreuter, J., & Glatzel, M. (2009). Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects. CLIN NEUROPATHOL, 28(3), 153-164. [3]. http://www.ncbi.nlm.nih.gov/pubmed/19537130?dopt=Citation

Vancouver

Hekmatara T, Bernreuther C, Khalansky AS, Theisen A, Weissenberger J, Matschke J et al. Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects. CLIN NEUROPATHOL. 2009;28(3):153-164. 3.

Bibtex

@article{99a7d95f0a28400f8f2c650e7dd5e46a,
title = "Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects.",
abstract = "The objective of this study was to investigate the therapeutic effects of doxorubicin bound to polysorbate-coated nanoparticles that had previously been shown to significantly enhance survival in the orthotopic rat 101/8 glioblastoma model. Tumor-bearing animals were subjected to chemotherapy using doxorubicin in solution (Dox-sol) or doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles (Dox-np) injected intravenously on Days 2, 5 and 8 post tumor implantation. The antitumor effect was assessed on Days 10, 14 and 18 post tumor implantation. Tumors showed signs of malignancy including invasion of brain tissue, brisk mitotic activity, microvascular proliferation, necrosis and increased proliferation resembling human glioblastoma. Dox-np produced a considerably more pronounced antitumor effect exhibited as a reduced tumor size, lower proliferation, and a decreased necrotic area compared to Dox-sol and to untreated control groups. A drastic effect of Dox-np on vascularization indicated an antiangiogenic mode of action.",
author = "T Hekmatara and Christian Bernreuther and Khalansky, {A S} and A Theisen and J Weissenberger and Jakob Matschke and S Gelperina and J Kreuter and Markus Glatzel",
year = "2009",
language = "Deutsch",
volume = "28",
pages = "153--164",
journal = "CLIN NEUROPATHOL",
issn = "0722-5091",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "3",

}

RIS

TY - JOUR

T1 - Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects.

AU - Hekmatara, T

AU - Bernreuther, Christian

AU - Khalansky, A S

AU - Theisen, A

AU - Weissenberger, J

AU - Matschke, Jakob

AU - Gelperina, S

AU - Kreuter, J

AU - Glatzel, Markus

PY - 2009

Y1 - 2009

N2 - The objective of this study was to investigate the therapeutic effects of doxorubicin bound to polysorbate-coated nanoparticles that had previously been shown to significantly enhance survival in the orthotopic rat 101/8 glioblastoma model. Tumor-bearing animals were subjected to chemotherapy using doxorubicin in solution (Dox-sol) or doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles (Dox-np) injected intravenously on Days 2, 5 and 8 post tumor implantation. The antitumor effect was assessed on Days 10, 14 and 18 post tumor implantation. Tumors showed signs of malignancy including invasion of brain tissue, brisk mitotic activity, microvascular proliferation, necrosis and increased proliferation resembling human glioblastoma. Dox-np produced a considerably more pronounced antitumor effect exhibited as a reduced tumor size, lower proliferation, and a decreased necrotic area compared to Dox-sol and to untreated control groups. A drastic effect of Dox-np on vascularization indicated an antiangiogenic mode of action.

AB - The objective of this study was to investigate the therapeutic effects of doxorubicin bound to polysorbate-coated nanoparticles that had previously been shown to significantly enhance survival in the orthotopic rat 101/8 glioblastoma model. Tumor-bearing animals were subjected to chemotherapy using doxorubicin in solution (Dox-sol) or doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles (Dox-np) injected intravenously on Days 2, 5 and 8 post tumor implantation. The antitumor effect was assessed on Days 10, 14 and 18 post tumor implantation. Tumors showed signs of malignancy including invasion of brain tissue, brisk mitotic activity, microvascular proliferation, necrosis and increased proliferation resembling human glioblastoma. Dox-np produced a considerably more pronounced antitumor effect exhibited as a reduced tumor size, lower proliferation, and a decreased necrotic area compared to Dox-sol and to untreated control groups. A drastic effect of Dox-np on vascularization indicated an antiangiogenic mode of action.

M3 - SCORING: Zeitschriftenaufsatz

VL - 28

SP - 153

EP - 164

JO - CLIN NEUROPATHOL

JF - CLIN NEUROPATHOL

SN - 0722-5091

IS - 3

M1 - 3

ER -