PortalPublikationenEfficient chemotherapy of rat glioblastoma using doxorubicin...

Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers.

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Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers. / Wohlfart, Stefanie; Khalansky, Alexander S; Gelperina, Svetlana; Maksimenko, Olga; Bernreuther, Christian; Glatzel, Markus; Kreuter, Jörg.

in: PLOS ONE, Jahrgang 6, Nr. 5, 5, 2011, S. 19121.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wohlfart, S, Khalansky, AS, Gelperina, S, Maksimenko, O, Bernreuther, C, Glatzel, M & Kreuter, J 2011, 'Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers.', PLOS ONE, Jg. 6, Nr. 5, 5, S. 19121. https://doi.org/10.1371/journal.pone.0019121

APA

Wohlfart, S., Khalansky, A. S., Gelperina, S., Maksimenko, O., Bernreuther, C., Glatzel, M., & Kreuter, J. (2011). Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers. PLOS ONE, 6(5), 19121. [5]. https://doi.org/10.1371/journal.pone.0019121

Vancouver

Wohlfart S, Khalansky AS, Gelperina S, Maksimenko O, Bernreuther C, Glatzel M et al. Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers. PLOS ONE. 2011;6(5):19121. 5. https://doi.org/10.1371/journal.pone.0019121

Bibtex

@article{171090bbb8ce4aacb430aa597fe4ee8b,
title = "Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers.",
abstract = "Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain. For an efficient treatment of glioblastomas it is necessary to deliver anti-cancer drugs across the intact BBB. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with poloxamer 188 hold great promise as drug carriers for brain delivery after their intravenous injection. In the present study the anti-tumour efficacy of the surfactant-coated doxorubicin-loaded PLGA nanoparticles against rat glioblastoma 101/8 was investigated using histological and immunohistochemical methods.",
keywords = "Animals, Humans, Male, Rats, Rats, Wistar, Lactic Acid/*chemistry, Polyglycolic Acid/*chemistry, Calorimetry, Differential Scanning, Doxorubicin/administration & dosage/*chemistry/*therapeutic use, Glial Fibrillary Acidic Protein/metabolism, Glioblastoma/*drug therapy/metabolism, Nanoparticles/administration & dosage/*chemistry, Vascular Endothelial Growth Factor A/metabolism, Animals, Humans, Male, Rats, Rats, Wistar, Lactic Acid/*chemistry, Polyglycolic Acid/*chemistry, Calorimetry, Differential Scanning, Doxorubicin/administration & dosage/*chemistry/*therapeutic use, Glial Fibrillary Acidic Protein/metabolism, Glioblastoma/*drug therapy/metabolism, Nanoparticles/administration & dosage/*chemistry, Vascular Endothelial Growth Factor A/metabolism",
author = "Stefanie Wohlfart and Khalansky, {Alexander S} and Svetlana Gelperina and Olga Maksimenko and Christian Bernreuther and Markus Glatzel and J{\"o}rg Kreuter",
year = "2011",
doi = "10.1371/journal.pone.0019121",
language = "English",
volume = "6",
pages = "19121",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers.

AU - Wohlfart, Stefanie

AU - Khalansky, Alexander S

AU - Gelperina, Svetlana

AU - Maksimenko, Olga

AU - Bernreuther, Christian

AU - Glatzel, Markus

AU - Kreuter, Jörg

PY - 2011

Y1 - 2011

N2 - Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain. For an efficient treatment of glioblastomas it is necessary to deliver anti-cancer drugs across the intact BBB. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with poloxamer 188 hold great promise as drug carriers for brain delivery after their intravenous injection. In the present study the anti-tumour efficacy of the surfactant-coated doxorubicin-loaded PLGA nanoparticles against rat glioblastoma 101/8 was investigated using histological and immunohistochemical methods.

AB - Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain. For an efficient treatment of glioblastomas it is necessary to deliver anti-cancer drugs across the intact BBB. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with poloxamer 188 hold great promise as drug carriers for brain delivery after their intravenous injection. In the present study the anti-tumour efficacy of the surfactant-coated doxorubicin-loaded PLGA nanoparticles against rat glioblastoma 101/8 was investigated using histological and immunohistochemical methods.

KW - Animals

KW - Humans

KW - Male

KW - Rats

KW - Rats, Wistar

KW - Lactic Acid/chemistry

KW - Polyglycolic Acid/chemistry

KW - Calorimetry, Differential Scanning

KW - Doxorubicin/administration & dosage/chemistry/therapeutic use

KW - Glial Fibrillary Acidic Protein/metabolism

KW - Glioblastoma/drug therapy/metabolism

KW - Nanoparticles/administration & dosage/chemistry

KW - Vascular Endothelial Growth Factor A/metabolism

KW - Animals

KW - Humans

KW - Male

KW - Rats

KW - Rats, Wistar

KW - Lactic Acid/chemistry

KW - Polyglycolic Acid/chemistry

KW - Calorimetry, Differential Scanning

KW - Doxorubicin/administration & dosage/chemistry/therapeutic use

KW - Glial Fibrillary Acidic Protein/metabolism

KW - Glioblastoma/drug therapy/metabolism

KW - Nanoparticles/administration & dosage/chemistry

KW - Vascular Endothelial Growth Factor A/metabolism

U2 - 10.1371/journal.pone.0019121

DO - 10.1371/journal.pone.0019121

M3 - SCORING: Journal article

VL - 6

SP - 19121

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 5

M1 - 5

ER -