Effects of continuous and triggered atrial overdrive pacing on paroxysmal atrial fibrillation in pacemaker patients
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Effects of continuous and triggered atrial overdrive pacing on paroxysmal atrial fibrillation in pacemaker patients. / Schuchert, Andreas; Rebeski, Hans-Peter; Peiffer, Thomas; Bub, Eberhard; Dietz, Armin; Mortensen, Kai; Aydin, Mohammed Ali; Camm, John; Gazarek, Steffen; Meinertz, Thomas; 3:4 Study Group.
in: PACE, Jahrgang 31, Nr. 8, 08.2008, S. 929-934.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Effects of continuous and triggered atrial overdrive pacing on paroxysmal atrial fibrillation in pacemaker patients
AU - Schuchert, Andreas
AU - Rebeski, Hans-Peter
AU - Peiffer, Thomas
AU - Bub, Eberhard
AU - Dietz, Armin
AU - Mortensen, Kai
AU - Aydin, Mohammed Ali
AU - Camm, John
AU - Gazarek, Steffen
AU - Meinertz, Thomas
AU - 3:4 Study Group
PY - 2008/8
Y1 - 2008/8
N2 - BACKGROUND: The aim of the study was to compare the effects of different pacing strategies to prevent paroxysmal atrial fibrillation (AF): triggered atrial overdrive pacing versus the combination of triggered and continuous overdrive pacing.METHODS: Patients with an indication for dual-chamber pacing (Selection 9000, Prevent AF; Vitatron B.V., Arnhem, the Netherlands) and a history of paroxysmal AF were randomized to triggered atrial pacing (three pacing functions, "triggered group": PAC Suppression, Post-PAC Response, and Post-Exercise Response) or to the combination of continuous (Pace Conditioning) and triggered atrial pacing (four pacing functions, "combined group"). After 3 months, there was a crossover to the other pacemaker setting.RESULTS: In 171 enrolled patients, the median AF burden of the combined group was with 2.1% versus 0.1% in the triggered group (P = 0.014). Fewer AF episodes were observed in the triggered (median: 7) than in the combined group (median: 116; P = 0.016). The combined group had more frequent atrial pacing (median 97%) than the triggered group with 85% (P < 0.001), but ventricular pacing was not significantly different with 95% and 96% in the combined and triggered group, respectively. After the crossover, the AF burden increased in the triggered group to 0.3% and decreased in the combined group to 0.4%.CONCLUSIONS: Triggered atrial pacing functions alone resulted in a low AF burden. The additional activation of continuous atrial overdrive pacing increased the percentage of atrial pacing, but had no beneficial effects on the prevention of paroxysmal AF.
AB - BACKGROUND: The aim of the study was to compare the effects of different pacing strategies to prevent paroxysmal atrial fibrillation (AF): triggered atrial overdrive pacing versus the combination of triggered and continuous overdrive pacing.METHODS: Patients with an indication for dual-chamber pacing (Selection 9000, Prevent AF; Vitatron B.V., Arnhem, the Netherlands) and a history of paroxysmal AF were randomized to triggered atrial pacing (three pacing functions, "triggered group": PAC Suppression, Post-PAC Response, and Post-Exercise Response) or to the combination of continuous (Pace Conditioning) and triggered atrial pacing (four pacing functions, "combined group"). After 3 months, there was a crossover to the other pacemaker setting.RESULTS: In 171 enrolled patients, the median AF burden of the combined group was with 2.1% versus 0.1% in the triggered group (P = 0.014). Fewer AF episodes were observed in the triggered (median: 7) than in the combined group (median: 116; P = 0.016). The combined group had more frequent atrial pacing (median 97%) than the triggered group with 85% (P < 0.001), but ventricular pacing was not significantly different with 95% and 96% in the combined and triggered group, respectively. After the crossover, the AF burden increased in the triggered group to 0.3% and decreased in the combined group to 0.4%.CONCLUSIONS: Triggered atrial pacing functions alone resulted in a low AF burden. The additional activation of continuous atrial overdrive pacing increased the percentage of atrial pacing, but had no beneficial effects on the prevention of paroxysmal AF.
KW - Aged
KW - Atrial Fibrillation/epidemiology
KW - Female
KW - Germany/epidemiology
KW - Humans
KW - Incidence
KW - Pacemaker, Artificial/statistics & numerical data
KW - Risk Assessment/methods
KW - Risk Factors
U2 - 10.1111/j.1540-8159.2008.01118.x
DO - 10.1111/j.1540-8159.2008.01118.x
M3 - SCORING: Journal article
C2 - 18684247
VL - 31
SP - 929
EP - 934
JO - PACE
JF - PACE
SN - 0147-8389
IS - 8
ER -