Effects of behavioral therapy or pharmacotherapy on brain glucose metabolism in subjects with obsessive-compulsive disorder as assessed by brain FDG PET.
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Effects of behavioral therapy or pharmacotherapy on brain glucose metabolism in subjects with obsessive-compulsive disorder as assessed by brain FDG PET. / Apostolova, Ivayla; Block, Suzette; Buchert, Ralph; Osen, Bernhard; Conradi, Miriam; Tabrizian, Susanne; Gensichen, Simon; Schröder-Hartwig, Karin; Fricke, Susanne; Rufer, Michael; Weiss, Angela; Hand, Iver; Clausen, Malte; Obrocki, Jost.
in: PSYCHIAT RES, Jahrgang 184, Nr. 2, 2, 2010, S. 105-116.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Effects of behavioral therapy or pharmacotherapy on brain glucose metabolism in subjects with obsessive-compulsive disorder as assessed by brain FDG PET.
AU - Apostolova, Ivayla
AU - Block, Suzette
AU - Buchert, Ralph
AU - Osen, Bernhard
AU - Conradi, Miriam
AU - Tabrizian, Susanne
AU - Gensichen, Simon
AU - Schröder-Hartwig, Karin
AU - Fricke, Susanne
AU - Rufer, Michael
AU - Weiss, Angela
AU - Hand, Iver
AU - Clausen, Malte
AU - Obrocki, Jost
PY - 2010
Y1 - 2010
N2 - This prospective study investigated the effect of pharmacotherapy (PT) and cognitive behavioral therapy (CBT) on cerebral glucose metabolism in adults with obsessive-compulsive disorder (OCD). Dynamic positron emission tomography (PET) of the brain with F-18-fluorodeoxyglucose (FDG) was performed before and after treatment in 16 subjects diagnosed for OCD for at least 2 years (PT: n=7). Pre-to-post-treatment change of scaled local metabolic rate of glucose (SLMRGlc) was assessed separately in therapy responders and non-responders. Correlation was tested between SLMRGlc change and change of OCD, depression, or anxiety symptoms. SLMRGlc increased in the right caudate after successful therapy. The increase tended to correlate with the improvement of OCD symptom severity. The finding of increased local caudate activity after successful therapy is in contrast to most previous studies. Possible explanations include effects of therapy on concomitant depression symptoms and/or the large proportion of early-onset OCD in the present sample.
AB - This prospective study investigated the effect of pharmacotherapy (PT) and cognitive behavioral therapy (CBT) on cerebral glucose metabolism in adults with obsessive-compulsive disorder (OCD). Dynamic positron emission tomography (PET) of the brain with F-18-fluorodeoxyglucose (FDG) was performed before and after treatment in 16 subjects diagnosed for OCD for at least 2 years (PT: n=7). Pre-to-post-treatment change of scaled local metabolic rate of glucose (SLMRGlc) was assessed separately in therapy responders and non-responders. Correlation was tested between SLMRGlc change and change of OCD, depression, or anxiety symptoms. SLMRGlc increased in the right caudate after successful therapy. The increase tended to correlate with the improvement of OCD symptom severity. The finding of increased local caudate activity after successful therapy is in contrast to most previous studies. Possible explanations include effects of therapy on concomitant depression symptoms and/or the large proportion of early-onset OCD in the present sample.
M3 - SCORING: Zeitschriftenaufsatz
VL - 184
SP - 105
EP - 116
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 2
M1 - 2
ER -
