Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia.
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Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia. / Stams, [Unbekannt]; Wendy, A G; Den, Boer; Monique, L; Beverloo, [Unbekannt]; Berna, H; Kazemier, [Unbekannt]; Karin, M; Wering, van; Elisabeth, R; Janka-Schaub, Gritta; Gritta, E; Pieters, [Unbekannt]; Rob, [Unbekannt].
in: HAEMATOLOGICA, Jahrgang 90, Nr. 12, 12, 2005, S. 1697-1699.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia.
AU - Stams, [Unbekannt]
AU - Wendy, A G
AU - Den, Boer
AU - Monique, L
AU - Beverloo, [Unbekannt]
AU - Berna, H
AU - Kazemier, [Unbekannt]
AU - Karin, M
AU - Wering, van
AU - Elisabeth, R
AU - Janka-Schaub, Gritta
AU - Gritta, E
AU - Pieters, [Unbekannt]
AU - Rob, [Unbekannt]
PY - 2005
Y1 - 2005
N2 - The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).
AB - The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).
M3 - SCORING: Zeitschriftenaufsatz
VL - 90
SP - 1697
EP - 1699
JO - HAEMATOLOGICA
JF - HAEMATOLOGICA
SN - 0390-6078
IS - 12
M1 - 12
ER -