Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke

  • J Röther
  • P D Schellinger
  • A Gass
  • M Siebler
  • A Villringer
  • J B Fiebach
  • Jens Fiehler
  • O Jansen
  • T Kucinski
  • V Schoder
  • K Szabo
  • G J Junge-Hülsing
  • M Hennerici
  • Hermann Zeumer
  • K Sartor
  • C Weiller
  • W Hacke

Abstract

BACKGROUND AND PURPOSE: The goals of this study were to examine MRI baseline characteristics of patients with acute ischemic stroke (AIS) and to study the influence of intravenous tissue plasminogen activator (tPA) on MR parameters and functional outcome using a multicenter approach. METHODS: In this open-label, nonrandomized study of AIS patients with suspected anterior circulation stroke, subjects received a multiparametric stroke MRI protocol (diffusion- and perfusion-weighted imaging and MR angiography) within 6 hours after symptom onset and on follow-up. Patients were treated either with tPA (thrombolysis group) or conservatively (no thrombolysis group). Functional outcome was assessed on day 90 (modified Rankin Score; mRS). RESULTS: We enrolled 139 AIS patients (no thrombolysis group, n=63; thrombolysis group, n=76). Patients treated with tPA were more severely affected (National Institutes of Health Stroke Scale score, 10 versus 13; P=0.002). Recanalization rates were higher in the thrombolysis group (Thrombolysis in Myocardial Infarction criteria 1 through 3 on day 1; 66.2% versus 32.7%; P

Bibliografische Daten

OriginalspracheDeutsch
Aufsatznummer10
ISSN0039-2499
StatusVeröffentlicht - 2002
pubmed 12364735