PortalPublikationenEffect of heat-shock protein-90 (HSP90) inhibition on human ...

Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models.

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  • Christina Hackl
  • Akira Mori
  • Christian Moser
  • Sven A Lang
  • Rania Dayoub
  • Thomas S Weiss
  • Hans J Schlitt
  • Edward K Geissler
  • Claus Hellerbrand
  • Oliver Stöltzing

Beteiligte Einrichtungen

Abstract

Targeting heat shock protein 90 (HSP90) has gained great interest for cancer therapy. However, in view of novel multimodality therapy approaches for treating hepatic metastases, concerns have raised regarding the impact of targeted therapies on liver regeneration and repair. In this study, we investigated the impact of HSP90 inhibition on liver regeneration in murine models.

Bibliografische Daten

OriginalspracheDeutsch
Aufsatznummer5
ISSN0039-6060
StatusVeröffentlicht - 2010
pubmed 20015528