Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models

M Navarra; M R Ursino; N Ferlazzo; M Russo; U Schumacher; U Valentiner

doi:10.1016/j.fitote.2014.02.009

Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models

Standard

Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models. / Navarra, M; Ursino, M R; Ferlazzo, N; Russo, M; Schumacher, U; Valentiner, U.

in: FITOTERAPIA, Jahrgang 95, 01.06.2014, S. 83-92.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Navarra, M, Ursino, MR, Ferlazzo, N, Russo, M, Schumacher, U & Valentiner, U 2014, 'Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models', FITOTERAPIA, Jg. 95, S. 83-92. https://doi.org/10.1016/j.fitote.2014.02.009

APA

Navarra, M., Ursino, M. R., Ferlazzo, N., Russo, M., Schumacher, U., & Valentiner, U. (2014). Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models. FITOTERAPIA, 95, 83-92. https://doi.org/10.1016/j.fitote.2014.02.009

Vancouver

Navarra M, Ursino MR, Ferlazzo N, Russo M, Schumacher U, Valentiner U. Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models. FITOTERAPIA. 2014 Jun 1;95:83-92. https://doi.org/10.1016/j.fitote.2014.02.009

Bibtex

@article{29b9f64a86f840dd9e9178c1da272e7c,

title = "Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models",

abstract = "Neuroblastoma is the most common extracranial pediatric solid tumor with poor prognosis in children with disseminated stage of disease. A number of studies show that molecules largely distributed in commonly consumed fruits and vegetables may have anti-tumor activity. In this study we evaluate the effect of Citrus bergamia (bergamot) juice (BJ) in vitro and in a spontaneous metastatic neuroblastoma SCID mouse model. Qualitative and quantitative characterizations of BJ flavonoid fractions were performed by RP-HPLC/PDA/MS. We show that BJ significantly affects SK-N-SH and LAN-1 cell proliferation in vitro, but fails to reduce primary tumor weight in vivo. Moreover, BJ reduced cell adhesiveness and invasion of LAN-1 and SK-N-SH cells in vitro and the number of pulmonary metastases under consideration of the number of tumor cells in the blood in mice inoculated with LAN-1 cells in vivo. These effects without any apparent sign of systemic toxicity confirm the potential clinical interest of BJ and lay the basis for further investigation in cancer.",

author = "M Navarra and Ursino, {M R} and N Ferlazzo and M Russo and U Schumacher and U Valentiner",

note = "Copyright {\textcopyright} 2014. Published by Elsevier B.V.",

year = "2014",

month = jun,

day = "1",

doi = "10.1016/j.fitote.2014.02.009",

language = "English",

volume = "95",

pages = "83--92",

journal = "FITOTERAPIA",

issn = "0367-326X",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models

AU - Navarra, M

AU - Ursino, M R

AU - Ferlazzo, N

AU - Russo, M

AU - Schumacher, U

AU - Valentiner, U

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Neuroblastoma is the most common extracranial pediatric solid tumor with poor prognosis in children with disseminated stage of disease. A number of studies show that molecules largely distributed in commonly consumed fruits and vegetables may have anti-tumor activity. In this study we evaluate the effect of Citrus bergamia (bergamot) juice (BJ) in vitro and in a spontaneous metastatic neuroblastoma SCID mouse model. Qualitative and quantitative characterizations of BJ flavonoid fractions were performed by RP-HPLC/PDA/MS. We show that BJ significantly affects SK-N-SH and LAN-1 cell proliferation in vitro, but fails to reduce primary tumor weight in vivo. Moreover, BJ reduced cell adhesiveness and invasion of LAN-1 and SK-N-SH cells in vitro and the number of pulmonary metastases under consideration of the number of tumor cells in the blood in mice inoculated with LAN-1 cells in vivo. These effects without any apparent sign of systemic toxicity confirm the potential clinical interest of BJ and lay the basis for further investigation in cancer.

AB - Neuroblastoma is the most common extracranial pediatric solid tumor with poor prognosis in children with disseminated stage of disease. A number of studies show that molecules largely distributed in commonly consumed fruits and vegetables may have anti-tumor activity. In this study we evaluate the effect of Citrus bergamia (bergamot) juice (BJ) in vitro and in a spontaneous metastatic neuroblastoma SCID mouse model. Qualitative and quantitative characterizations of BJ flavonoid fractions were performed by RP-HPLC/PDA/MS. We show that BJ significantly affects SK-N-SH and LAN-1 cell proliferation in vitro, but fails to reduce primary tumor weight in vivo. Moreover, BJ reduced cell adhesiveness and invasion of LAN-1 and SK-N-SH cells in vitro and the number of pulmonary metastases under consideration of the number of tumor cells in the blood in mice inoculated with LAN-1 cells in vivo. These effects without any apparent sign of systemic toxicity confirm the potential clinical interest of BJ and lay the basis for further investigation in cancer.

U2 - 10.1016/j.fitote.2014.02.009

DO - 10.1016/j.fitote.2014.02.009

M3 - SCORING: Journal article

C2 - 24594241

VL - 95

SP - 83

EP - 92

JO - FITOTERAPIA

JF - FITOTERAPIA

SN - 0367-326X

ER -