PortalPublikationenEBV renders B cells susceptible to HIV-1 in humanized mice

EBV renders B cells susceptible to HIV-1 in humanized mice

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EBV renders B cells susceptible to HIV-1 in humanized mice. / McHugh, Donal; Myburgh, Renier; Caduff, Nicole; Spohn, Michael; Kok, Yik Lim; Keller, Christian W; Murer, Anita; Chatterjee, Bithi; Rühl, Julia; Engelmann, Christine; Chijioke, Obinna; Quast, Isaak; Shilaih, Mohaned; Strouvelle, Victoria P; Neumann, Kathrin; Menter, Thomas; Dirnhofer, Stephan; Lam, Janice Kp; Hui, Kwai F; Bredl, Simon; Schlaepfer, Erika; Sorce, Silvia; Zbinden, Andrea; Capaul, Riccarda; Lünemann, Jan D; Aguzzi, Adriano; Chiang, Alan Ks; Kempf, Werner; Trkola, Alexandra; Metzner, Karin J; Manz, Markus G; Grundhoff, Adam; Speck, Roberto F; Münz, Christian.

in: LIFE SCI ALLIANCE, Jahrgang 3, Nr. 8, 08.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

McHugh, D, Myburgh, R, Caduff, N, Spohn, M, Kok, YL, Keller, CW, Murer, A, Chatterjee, B, Rühl, J, Engelmann, C, Chijioke, O, Quast, I, Shilaih, M, Strouvelle, VP, Neumann, K, Menter, T, Dirnhofer, S, Lam, JK, Hui, KF, Bredl, S, Schlaepfer, E, Sorce, S, Zbinden, A, Capaul, R, Lünemann, JD, Aguzzi, A, Chiang, AK, Kempf, W, Trkola, A, Metzner, KJ, Manz, MG, Grundhoff, A, Speck, RF & Münz, C 2020, 'EBV renders B cells susceptible to HIV-1 in humanized mice', LIFE SCI ALLIANCE, Jg. 3, Nr. 8. https://doi.org/10.26508/lsa.202000640

APA

McHugh, D., Myburgh, R., Caduff, N., Spohn, M., Kok, Y. L., Keller, C. W., Murer, A., Chatterjee, B., Rühl, J., Engelmann, C., Chijioke, O., Quast, I., Shilaih, M., Strouvelle, V. P., Neumann, K., Menter, T., Dirnhofer, S., Lam, J. K., Hui, K. F., ... Münz, C. (2020). EBV renders B cells susceptible to HIV-1 in humanized mice. LIFE SCI ALLIANCE, 3(8). https://doi.org/10.26508/lsa.202000640

Vancouver

McHugh D, Myburgh R, Caduff N, Spohn M, Kok YL, Keller CW et al. EBV renders B cells susceptible to HIV-1 in humanized mice. LIFE SCI ALLIANCE. 2020 Aug;3(8). https://doi.org/10.26508/lsa.202000640

Bibtex

@article{5c740865134c42abb0b21966b0049e0f,
title = "EBV renders B cells susceptible to HIV-1 in humanized mice",
abstract = "HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4+ T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34+ human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8+ T-cell-mediated immune control.",
author = "Donal McHugh and Renier Myburgh and Nicole Caduff and Michael Spohn and Kok, {Yik Lim} and Keller, {Christian W} and Anita Murer and Bithi Chatterjee and Julia R{\"u}hl and Christine Engelmann and Obinna Chijioke and Isaak Quast and Mohaned Shilaih and Strouvelle, {Victoria P} and Kathrin Neumann and Thomas Menter and Stephan Dirnhofer and Lam, {Janice Kp} and Hui, {Kwai F} and Simon Bredl and Erika Schlaepfer and Silvia Sorce and Andrea Zbinden and Riccarda Capaul and L{\"u}nemann, {Jan D} and Adriano Aguzzi and Chiang, {Alan Ks} and Werner Kempf and Alexandra Trkola and Metzner, {Karin J} and Manz, {Markus G} and Adam Grundhoff and Speck, {Roberto F} and Christian M{\"u}nz",
note = "{\textcopyright} 2020 McHugh et al.",
year = "2020",
month = aug,
doi = "10.26508/lsa.202000640",
language = "English",
volume = "3",
journal = "LIFE SCI ALLIANCE",
issn = "2575-1077",
publisher = "Rockefeller University Press",
number = "8",

}

RIS

TY - JOUR

T1 - EBV renders B cells susceptible to HIV-1 in humanized mice

AU - McHugh, Donal

AU - Myburgh, Renier

AU - Caduff, Nicole

AU - Spohn, Michael

AU - Kok, Yik Lim

AU - Keller, Christian W

AU - Murer, Anita

AU - Chatterjee, Bithi

AU - Rühl, Julia

AU - Engelmann, Christine

AU - Chijioke, Obinna

AU - Quast, Isaak

AU - Shilaih, Mohaned

AU - Strouvelle, Victoria P

AU - Neumann, Kathrin

AU - Menter, Thomas

AU - Dirnhofer, Stephan

AU - Lam, Janice Kp

AU - Hui, Kwai F

AU - Bredl, Simon

AU - Schlaepfer, Erika

AU - Sorce, Silvia

AU - Zbinden, Andrea

AU - Capaul, Riccarda

AU - Lünemann, Jan D

AU - Aguzzi, Adriano

AU - Chiang, Alan Ks

AU - Kempf, Werner

AU - Trkola, Alexandra

AU - Metzner, Karin J

AU - Manz, Markus G

AU - Grundhoff, Adam

AU - Speck, Roberto F

AU - Münz, Christian

N1 - © 2020 McHugh et al.

PY - 2020/8

Y1 - 2020/8

N2 - HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4+ T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34+ human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8+ T-cell-mediated immune control.

AB - HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4+ T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34+ human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8+ T-cell-mediated immune control.

U2 - 10.26508/lsa.202000640

DO - 10.26508/lsa.202000640

M3 - SCORING: Journal article

C2 - 32576602

VL - 3

JO - LIFE SCI ALLIANCE

JF - LIFE SCI ALLIANCE

SN - 2575-1077

IS - 8

ER -