Dynamics of the interaction of γδ T cells with their neighbors in vivo
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Dynamics of the interaction of γδ T cells with their neighbors in vivo. / Prinz, Immo.
in: CELL MOL LIFE SCI, Jahrgang 68, Nr. 14, 07.2011, S. 2391-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Dynamics of the interaction of γδ T cells with their neighbors in vivo
AU - Prinz, Immo
PY - 2011/7
Y1 - 2011/7
N2 - γδ T cells are a diverse component of the immune system in humans and mice with presumably important but still largely unknown functions. Understanding the dynamic interaction of γδ T cells with their neighbors should help to understand their physiological role. This review addresses recent advances and strategies to visualize the dynamic interactions of γδ T cells with their neighbors in vivo. Current knowledge regarding the dynamic contacts of tissue resident γδ T cells and epithelial cells, but also of the communication between circulating γδ T cells and DCs, monocytes and FoxP3(+) regulatory T cells is revisited with emphasis on the role of γδ T cell motility.
AB - γδ T cells are a diverse component of the immune system in humans and mice with presumably important but still largely unknown functions. Understanding the dynamic interaction of γδ T cells with their neighbors should help to understand their physiological role. This review addresses recent advances and strategies to visualize the dynamic interactions of γδ T cells with their neighbors in vivo. Current knowledge regarding the dynamic contacts of tissue resident γδ T cells and epithelial cells, but also of the communication between circulating γδ T cells and DCs, monocytes and FoxP3(+) regulatory T cells is revisited with emphasis on the role of γδ T cell motility.
KW - Animals
KW - Cell Communication/immunology
KW - Dendritic Cells/immunology
KW - Green Fluorescent Proteins/genetics
KW - Humans
KW - Mice
KW - Microscopy, Confocal/methods
KW - Microscopy, Fluorescence, Multiphoton/methods
KW - Receptors, Antigen, T-Cell, gamma-delta/genetics
KW - T-Lymphocytes/immunology
KW - T-Lymphocytes, Regulatory/immunology
U2 - 10.1007/s00018-011-0701-y
DO - 10.1007/s00018-011-0701-y
M3 - SCORING: Review article
C2 - 21584813
VL - 68
SP - 2391
EP - 2398
JO - CELL MOL LIFE SCI
JF - CELL MOL LIFE SCI
SN - 1420-682X
IS - 14
ER -