DOG1 is commonly expressed in pancreatic adenocarcinoma but unrelated to cancer aggressiveness
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DOG1 is commonly expressed in pancreatic adenocarcinoma but unrelated to cancer aggressiveness. / Jansen, Kristina; Büscheck, Franziska; Moeller, Katharina; Kluth, Martina; Hube-Magg, Claudia; Blessin, Niclas Christian; Perez, Daniel; Izbicki, Jakob; Neipp, Michael; Mofid, Hamid; Daniels, Thies; Nahrstedt, Ulf; Fraune, Christoph; Jacobsen, Frank; Bernreuther, Christian; Lebok, Patrick; Sauter, Guido; Uhlig, Ria; Wilczak, Waldemar; Simon, Ronald; Steurer, Stefan; Burandt, Eike; Marx, Andreas; Krech, Till; Clauditz, Till.
in: PEERJ, Jahrgang 9, e11905, 2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - DOG1 is commonly expressed in pancreatic adenocarcinoma but unrelated to cancer aggressiveness
AU - Jansen, Kristina
AU - Büscheck, Franziska
AU - Moeller, Katharina
AU - Kluth, Martina
AU - Hube-Magg, Claudia
AU - Blessin, Niclas Christian
AU - Perez, Daniel
AU - Izbicki, Jakob
AU - Neipp, Michael
AU - Mofid, Hamid
AU - Daniels, Thies
AU - Nahrstedt, Ulf
AU - Fraune, Christoph
AU - Jacobsen, Frank
AU - Bernreuther, Christian
AU - Lebok, Patrick
AU - Sauter, Guido
AU - Uhlig, Ria
AU - Wilczak, Waldemar
AU - Simon, Ronald
AU - Steurer, Stefan
AU - Burandt, Eike
AU - Marx, Andreas
AU - Krech, Till
AU - Clauditz, Till
N1 - ©2021 Jansen et al.
PY - 2021
Y1 - 2021
N2 - Background: DOG1 (ANO1; TMEM16A) is a voltage-gated calcium-activated chloride and bicarbonate channel. DOG1 is physiologically expressed in Cajal cells, where it plays an important role in regulating intestinal motility and its expression is a diagnostic hallmark of gastrointestinal stromal tumors (GIST). Data on a possible role of DOG1 in pancreatic cancer are rare and controversial. The aim of our study was to clarify the prevalence of DOG1 expression in pancreatic cancer and to study its association with parameters of cancer aggressiveness.Methods: DOG1 expression was analyzed by immunohistochemistry in 599 pancreatic cancers in a tissue microarray format and in 12 cases of pancreatitis on large tissue sections.Results: DOG1 expression was always absent in normal pancreas but a focal weak expression was seen in four of 12 cases of pancreatitis. DOG1 expression was, however, common in pancreatic cancer. Membranous and cytoplasmic DOG1 expression in tumor cells was highest in pancreatic ductal adenocarcinomas (61% of 444 interpretable cases), followed by cancers of the ampulla Vateri (43% of 51 interpretable cases), and absent in 6 acinus cell carcinomas. DOG1 expression in tumor associated stroma cells was seen in 76 of 444 (17%) pancreatic ductal adenocarcinomas and in seven of 51 (14%) cancers of the ampulla Vateri. Both tumoral and stromal DOG1 expression were unrelated to tumor stage, grade, lymph node and distant metastasis, mismatch repair protein deficiency and the density of CD8 positive cytotoxic T-lymphocytes in the subgroups of ductal adenocarcinomas and cancers of ampulla Vateri. Overall, the results of our study indicate that DOG1 may represent a potential biomarker for pancreatic cancer diagnosis and a putative therapeutic target in pancreatic cancer. However, DOG1 expression is unrelated to pancreatic cancer aggressiveness.
AB - Background: DOG1 (ANO1; TMEM16A) is a voltage-gated calcium-activated chloride and bicarbonate channel. DOG1 is physiologically expressed in Cajal cells, where it plays an important role in regulating intestinal motility and its expression is a diagnostic hallmark of gastrointestinal stromal tumors (GIST). Data on a possible role of DOG1 in pancreatic cancer are rare and controversial. The aim of our study was to clarify the prevalence of DOG1 expression in pancreatic cancer and to study its association with parameters of cancer aggressiveness.Methods: DOG1 expression was analyzed by immunohistochemistry in 599 pancreatic cancers in a tissue microarray format and in 12 cases of pancreatitis on large tissue sections.Results: DOG1 expression was always absent in normal pancreas but a focal weak expression was seen in four of 12 cases of pancreatitis. DOG1 expression was, however, common in pancreatic cancer. Membranous and cytoplasmic DOG1 expression in tumor cells was highest in pancreatic ductal adenocarcinomas (61% of 444 interpretable cases), followed by cancers of the ampulla Vateri (43% of 51 interpretable cases), and absent in 6 acinus cell carcinomas. DOG1 expression in tumor associated stroma cells was seen in 76 of 444 (17%) pancreatic ductal adenocarcinomas and in seven of 51 (14%) cancers of the ampulla Vateri. Both tumoral and stromal DOG1 expression were unrelated to tumor stage, grade, lymph node and distant metastasis, mismatch repair protein deficiency and the density of CD8 positive cytotoxic T-lymphocytes in the subgroups of ductal adenocarcinomas and cancers of ampulla Vateri. Overall, the results of our study indicate that DOG1 may represent a potential biomarker for pancreatic cancer diagnosis and a putative therapeutic target in pancreatic cancer. However, DOG1 expression is unrelated to pancreatic cancer aggressiveness.
U2 - 10.7717/peerj.11905
DO - 10.7717/peerj.11905
M3 - SCORING: Journal article
C2 - 34414034
VL - 9
JO - PEERJ
JF - PEERJ
SN - 2167-8359
M1 - e11905
ER -
