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DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer

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DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. / Weigel, Christoph; Chaisaingmongkol, Jittiporn; Assenov, Yassen; Kuhmann, Christine; Winkler, Volker; Santi, Irene; Bogatyrova, Olga; Kaucher, Simone; Bermejo, Justo L; Leung, Suet Y; Chan, Tsun L; Lasitschka, Felix; Bohrer, Manfred H; Marx, Alexander; Haußen, Roland Heyny-von; Herold-Mende, Christel; Dyckhoff, Gerhard; Boukamp, Petra; Delank, Klaus W; Hörmann, Karl; Lippert, Burkhard M; Baier, Gerald; Dietz, Andreas; Oakes, Christopher C; Plass, Christoph; Becher, Heiko; Schmezer, Peter; Ramroth, Heribert; Popanda, Odilia.

in: CLIN EPIGENETICS, Jahrgang 11, Nr. 1, 03.05.2019, S. 67.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Weigel, C, Chaisaingmongkol, J, Assenov, Y, Kuhmann, C, Winkler, V, Santi, I, Bogatyrova, O, Kaucher, S, Bermejo, JL, Leung, SY, Chan, TL, Lasitschka, F, Bohrer, MH, Marx, A, Haußen, RH, Herold-Mende, C, Dyckhoff, G, Boukamp, P, Delank, KW, Hörmann, K, Lippert, BM, Baier, G, Dietz, A, Oakes, CC, Plass, C, Becher, H, Schmezer, P, Ramroth, H & Popanda, O 2019, 'DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer', CLIN EPIGENETICS, Jg. 11, Nr. 1, S. 67. https://doi.org/10.1186/s13148-019-0666-5

APA

Weigel, C., Chaisaingmongkol, J., Assenov, Y., Kuhmann, C., Winkler, V., Santi, I., Bogatyrova, O., Kaucher, S., Bermejo, J. L., Leung, S. Y., Chan, T. L., Lasitschka, F., Bohrer, M. H., Marx, A., Haußen, R. H., Herold-Mende, C., Dyckhoff, G., Boukamp, P., Delank, K. W., ... Popanda, O. (2019). DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. CLIN EPIGENETICS, 11(1), 67. https://doi.org/10.1186/s13148-019-0666-5

Vancouver

Weigel C, Chaisaingmongkol J, Assenov Y, Kuhmann C, Winkler V, Santi I et al. DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. CLIN EPIGENETICS. 2019 Mai 3;11(1):67. https://doi.org/10.1186/s13148-019-0666-5

Bibtex

@article{befc4183a16a4c2ba84dccac802b4caf,
title = "DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer",
abstract = "BACKGROUND: Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA).RESULTS: Significant methylation loss at an intragenic site of TREX2 was a frequent trait in both patient cohorts (p = 0.016 and < 0.001, respectively) and in 15 out of 22 TCGA studies. Methylation loss correlated with immunohistochemically staining for TREX2 (p < 0.0001) in laryngeal tumors and improved overall survival of laryngeal cancer patients (p = 0.045). Chromatin immunoprecipitation, demethylation experiments, and reporter gene assays revealed that the region of methylation loss can function as a CCAAT/enhancer binding protein alpha (CEBPA)-responsive enhancer element regulating TREX2 expression.CONCLUSIONS: The data highlight a regulatory role of TREX2 DNA methylation for gene expression which might affect incidence and survival of laryngeal cancer. Altered TREX2 protein levels in tumors may affect drug-induced DNA damage repair and provide new tailored therapies.",
author = "Christoph Weigel and Jittiporn Chaisaingmongkol and Yassen Assenov and Christine Kuhmann and Volker Winkler and Irene Santi and Olga Bogatyrova and Simone Kaucher and Bermejo, {Justo L} and Leung, {Suet Y} and Chan, {Tsun L} and Felix Lasitschka and Bohrer, {Manfred H} and Alexander Marx and Hau{\ss}en, {Roland Heyny-von} and Christel Herold-Mende and Gerhard Dyckhoff and Petra Boukamp and Delank, {Klaus W} and Karl H{\"o}rmann and Lippert, {Burkhard M} and Gerald Baier and Andreas Dietz and Oakes, {Christopher C} and Christoph Plass and Heiko Becher and Peter Schmezer and Heribert Ramroth and Odilia Popanda",
year = "2019",
month = may,
day = "3",
doi = "10.1186/s13148-019-0666-5",
language = "English",
volume = "11",
pages = "67",
journal = "CLIN EPIGENETICS",
issn = "1868-7075",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer

AU - Weigel, Christoph

AU - Chaisaingmongkol, Jittiporn

AU - Assenov, Yassen

AU - Kuhmann, Christine

AU - Winkler, Volker

AU - Santi, Irene

AU - Bogatyrova, Olga

AU - Kaucher, Simone

AU - Bermejo, Justo L

AU - Leung, Suet Y

AU - Chan, Tsun L

AU - Lasitschka, Felix

AU - Bohrer, Manfred H

AU - Marx, Alexander

AU - Haußen, Roland Heyny-von

AU - Herold-Mende, Christel

AU - Dyckhoff, Gerhard

AU - Boukamp, Petra

AU - Delank, Klaus W

AU - Hörmann, Karl

AU - Lippert, Burkhard M

AU - Baier, Gerald

AU - Dietz, Andreas

AU - Oakes, Christopher C

AU - Plass, Christoph

AU - Becher, Heiko

AU - Schmezer, Peter

AU - Ramroth, Heribert

AU - Popanda, Odilia

PY - 2019/5/3

Y1 - 2019/5/3

N2 - BACKGROUND: Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA).RESULTS: Significant methylation loss at an intragenic site of TREX2 was a frequent trait in both patient cohorts (p = 0.016 and < 0.001, respectively) and in 15 out of 22 TCGA studies. Methylation loss correlated with immunohistochemically staining for TREX2 (p < 0.0001) in laryngeal tumors and improved overall survival of laryngeal cancer patients (p = 0.045). Chromatin immunoprecipitation, demethylation experiments, and reporter gene assays revealed that the region of methylation loss can function as a CCAAT/enhancer binding protein alpha (CEBPA)-responsive enhancer element regulating TREX2 expression.CONCLUSIONS: The data highlight a regulatory role of TREX2 DNA methylation for gene expression which might affect incidence and survival of laryngeal cancer. Altered TREX2 protein levels in tumors may affect drug-induced DNA damage repair and provide new tailored therapies.

AB - BACKGROUND: Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA).RESULTS: Significant methylation loss at an intragenic site of TREX2 was a frequent trait in both patient cohorts (p = 0.016 and < 0.001, respectively) and in 15 out of 22 TCGA studies. Methylation loss correlated with immunohistochemically staining for TREX2 (p < 0.0001) in laryngeal tumors and improved overall survival of laryngeal cancer patients (p = 0.045). Chromatin immunoprecipitation, demethylation experiments, and reporter gene assays revealed that the region of methylation loss can function as a CCAAT/enhancer binding protein alpha (CEBPA)-responsive enhancer element regulating TREX2 expression.CONCLUSIONS: The data highlight a regulatory role of TREX2 DNA methylation for gene expression which might affect incidence and survival of laryngeal cancer. Altered TREX2 protein levels in tumors may affect drug-induced DNA damage repair and provide new tailored therapies.

U2 - 10.1186/s13148-019-0666-5

DO - 10.1186/s13148-019-0666-5

M3 - SCORING: Journal article

C2 - 31053176

VL - 11

SP - 67

JO - CLIN EPIGENETICS

JF - CLIN EPIGENETICS

SN - 1868-7075

IS - 1

ER -