DNA damage by X-rays and their impact on replication processes.
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DNA damage by X-rays and their impact on replication processes. / Parplys, Ann Christin; Petermann, Eva; Petersen, Cordula; Dikomey, Ekkehard; Borgmann, Kerstin.
in: RADIOTHER ONCOL, Jahrgang 102, Nr. 3, 3, 2012, S. 466-471.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - DNA damage by X-rays and their impact on replication processes.
AU - Parplys, Ann Christin
AU - Petermann, Eva
AU - Petersen, Cordula
AU - Dikomey, Ekkehard
AU - Borgmann, Kerstin
PY - 2012
Y1 - 2012
N2 - Replication-dependent radiosensitization of tumors ranks among the most promising tools for future improvements in tumor therapy. However, cell cycle checkpoint signaling during S phase is a key for maintaining genomic stability after ionizing irradiation allowing DNA damage repair by stabilizing replication forks, inhibiting new origin firing and recruiting DNA repair proteins. As the impact of the different types of DNA damage induced by ionizing radiation on replication fork functionality has not been investigated, this study was performed in tumor cells treated with various agents that induce specific DNA lesions.
AB - Replication-dependent radiosensitization of tumors ranks among the most promising tools for future improvements in tumor therapy. However, cell cycle checkpoint signaling during S phase is a key for maintaining genomic stability after ionizing irradiation allowing DNA damage repair by stabilizing replication forks, inhibiting new origin firing and recruiting DNA repair proteins. As the impact of the different types of DNA damage induced by ionizing radiation on replication fork functionality has not been investigated, this study was performed in tumor cells treated with various agents that induce specific DNA lesions.
M3 - SCORING: Journal article
VL - 102
SP - 466
EP - 471
JO - RADIOTHER ONCOL
JF - RADIOTHER ONCOL
SN - 0167-8140
IS - 3
M1 - 3
ER -