Diverse prognostic value of the GTn promoter polymorphism in squamous cell and adeno carcinoma of the esophageus
Standard
Diverse prognostic value of the GTn promoter polymorphism in squamous cell and adeno carcinoma of the esophageus. / Ghadban, Tarik; Miro, Jameel T; Trump, Florian; Tsui, Tung Yu; Uzunoglu, Faik Guentac; Reeh, Matthias; Gebauer, Florian; Bachmann, Kai; Wellner, Ulrich; Kalinin, Viacheslav; Pantel, Klaus; Izbicki, Jakob R; Vashist, Yogesh K.
in: CLIN GENET, Jahrgang 90, Nr. 4, 25.02.2016, S. 343-50.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Diverse prognostic value of the GTn promoter polymorphism in squamous cell and adeno carcinoma of the esophageus
AU - Ghadban, Tarik
AU - Miro, Jameel T
AU - Trump, Florian
AU - Tsui, Tung Yu
AU - Uzunoglu, Faik Guentac
AU - Reeh, Matthias
AU - Gebauer, Florian
AU - Bachmann, Kai
AU - Wellner, Ulrich
AU - Kalinin, Viacheslav
AU - Pantel, Klaus
AU - Izbicki, Jakob R
AU - Vashist, Yogesh K
N1 - This article is protected by copyright. All rights reserved.
PY - 2016/2/25
Y1 - 2016/2/25
N2 - The basal transcription of heme-oxygenase-1 (HO-1) regulation is dependent upon a GT repeat germ line polymorphism (GTn) in the promoter of the HO-1 gene. We determined the prognostic value of HO-1 promoter polymorphism on the natural postoperative course of complete resected esophageal cancer (EC). Genomic DNA from 297 patients was amplified by PCR and sequenced. The results were correlated with clinico-pathological parameters, disseminated tumor cells in bone marrow (DTC) and clinical outcome. Depending on short allele with <25 and long allele with ≥25 GTn repeats three genotypes (SS, SL and LL) were defined. A diverse role of GTn was evident in squamous cell carcinoma (SCC) and adenocarcinoma (AC). In SCC the SS genotype presented less advanced tumors with lower rate DTC in bone marrow and relapse compared to L-allele carriers. In contrast AC patients with the SS genotype displayed a complete opposing tumor characteristic. The disease-free (DFS) and overall survival (OS) in SCC patients was markedly reduced in LL genotypes (P < 0.001). In AC contrarily the SS genotype patients displayed the worst DFS and OS (P < 0.001). GTn is a strong prognostic factor with diverse prognostic value for recurrence and survival in AC and SCC.
AB - The basal transcription of heme-oxygenase-1 (HO-1) regulation is dependent upon a GT repeat germ line polymorphism (GTn) in the promoter of the HO-1 gene. We determined the prognostic value of HO-1 promoter polymorphism on the natural postoperative course of complete resected esophageal cancer (EC). Genomic DNA from 297 patients was amplified by PCR and sequenced. The results were correlated with clinico-pathological parameters, disseminated tumor cells in bone marrow (DTC) and clinical outcome. Depending on short allele with <25 and long allele with ≥25 GTn repeats three genotypes (SS, SL and LL) were defined. A diverse role of GTn was evident in squamous cell carcinoma (SCC) and adenocarcinoma (AC). In SCC the SS genotype presented less advanced tumors with lower rate DTC in bone marrow and relapse compared to L-allele carriers. In contrast AC patients with the SS genotype displayed a complete opposing tumor characteristic. The disease-free (DFS) and overall survival (OS) in SCC patients was markedly reduced in LL genotypes (P < 0.001). In AC contrarily the SS genotype patients displayed the worst DFS and OS (P < 0.001). GTn is a strong prognostic factor with diverse prognostic value for recurrence and survival in AC and SCC.
U2 - 10.1111/cge.12765
DO - 10.1111/cge.12765
M3 - SCORING: Journal article
C2 - 26916598
VL - 90
SP - 343
EP - 350
JO - CLIN GENET
JF - CLIN GENET
SN - 0009-9163
IS - 4
ER -
