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Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study

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Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study. / Mikita, N; Simonoff, E; Pine, D S; Goodman, R; Artiges, E; Banaschewski, T; Bokde, A L; Bromberg, U; Büchel, C; Cattrell, A; Conrod, P J; Desrivières, S; Flor, H; Frouin, V; Gallinat, J; Garavan, H; Heinz, A; Ittermann, B; Jurk, S; Martinot, J L; Paillère Martinot, M L; Nees, F; Papadopoulos Orfanos, D; Paus, T; Poustka, L; Smolka, M N; Walter, H; Whelan, R; Schumann, G; Stringaris, A.

in: TRANSL PSYCHIAT, Jahrgang 6, 2016, S. e845.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mikita, N, Simonoff, E, Pine, DS, Goodman, R, Artiges, E, Banaschewski, T, Bokde, AL, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Heinz, A, Ittermann, B, Jurk, S, Martinot, JL, Paillère Martinot, ML, Nees, F, Papadopoulos Orfanos, D, Paus, T, Poustka, L, Smolka, MN, Walter, H, Whelan, R, Schumann, G & Stringaris, A 2016, 'Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study', TRANSL PSYCHIAT, Jg. 6, S. e845. https://doi.org/10.1038/tp.2016.107

APA

Mikita, N., Simonoff, E., Pine, D. S., Goodman, R., Artiges, E., Banaschewski, T., Bokde, A. L., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Heinz, A., Ittermann, B., Jurk, S., ... Stringaris, A. (2016). Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study. TRANSL PSYCHIAT, 6, e845. https://doi.org/10.1038/tp.2016.107

Vancouver

Mikita N, Simonoff E, Pine DS, Goodman R, Artiges E, Banaschewski T et al. Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study. TRANSL PSYCHIAT. 2016;6:e845. https://doi.org/10.1038/tp.2016.107

Bibtex

@article{c5925d3a9c454f1780fcfda814c94513,
title = "Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study",
abstract = "Up to 40% of youth with autism spectrum disorder (ASD) also suffer from anxiety, and this comorbidity is linked with significant functional impairment. However, the mechanisms of this overlap are poorly understood. We investigated the interplay between ASD traits and anxiety during reward processing, known to be affected in ASD, in a community sample of 1472 adolescents (mean age=14.4 years) who performed a modified monetary incentive delay task as part of the Imagen project. Blood-oxygen-level dependent (BOLD) responses to reward anticipation and feedback were compared using a 2x2 analysis of variance test (ASD traits: low/high; anxiety symptoms: low/high), controlling for plausible covariates. In addition, we used a longitudinal design to assess whether neural responses during reward processing predicted anxiety at 2-year follow-up. High ASD traits were associated with reduced BOLD responses in dorsal prefrontal regions during reward anticipation and negative feedback. Participants with high anxiety symptoms showed increased lateral prefrontal responses during anticipation, but decreased responses following feedback. Interaction effects revealed that youth with combined ASD traits and anxiety, relative to other youth, showed high right insula activation when anticipating reward, and low right-sided caudate, putamen, medial and lateral prefrontal activations during negative feedback (all clusters PFWE<0.05). BOLD activation patterns in the right dorsal cingulate and right medial frontal gyrus predicted new-onset anxiety in participants with high but not low ASD traits. Our results reveal both quantitatively enhanced and qualitatively distinct neural correlates underlying the comorbidity between ASD traits and anxiety. Specific neural responses during reward processing may represent a risk factor for developing anxiety in ASD youth.",
author = "N Mikita and E Simonoff and Pine, {D S} and R Goodman and E Artiges and T Banaschewski and Bokde, {A L} and U Bromberg and C B{\"u}chel and A Cattrell and Conrod, {P J} and S Desrivi{\`e}res and H Flor and V Frouin and J Gallinat and H Garavan and A Heinz and B Ittermann and S Jurk and Martinot, {J L} and {Paill{\`e}re Martinot}, {M L} and F Nees and {Papadopoulos Orfanos}, D and T Paus and L Poustka and Smolka, {M N} and H Walter and R Whelan and G Schumann and A Stringaris",
year = "2016",
doi = "10.1038/tp.2016.107",
language = "English",
volume = "6",
pages = "e845",
journal = "TRANSL PSYCHIAT",
issn = "2158-3188",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study

AU - Mikita, N

AU - Simonoff, E

AU - Pine, D S

AU - Goodman, R

AU - Artiges, E

AU - Banaschewski, T

AU - Bokde, A L

AU - Bromberg, U

AU - Büchel, C

AU - Cattrell, A

AU - Conrod, P J

AU - Desrivières, S

AU - Flor, H

AU - Frouin, V

AU - Gallinat, J

AU - Garavan, H

AU - Heinz, A

AU - Ittermann, B

AU - Jurk, S

AU - Martinot, J L

AU - Paillère Martinot, M L

AU - Nees, F

AU - Papadopoulos Orfanos, D

AU - Paus, T

AU - Poustka, L

AU - Smolka, M N

AU - Walter, H

AU - Whelan, R

AU - Schumann, G

AU - Stringaris, A

PY - 2016

Y1 - 2016

N2 - Up to 40% of youth with autism spectrum disorder (ASD) also suffer from anxiety, and this comorbidity is linked with significant functional impairment. However, the mechanisms of this overlap are poorly understood. We investigated the interplay between ASD traits and anxiety during reward processing, known to be affected in ASD, in a community sample of 1472 adolescents (mean age=14.4 years) who performed a modified monetary incentive delay task as part of the Imagen project. Blood-oxygen-level dependent (BOLD) responses to reward anticipation and feedback were compared using a 2x2 analysis of variance test (ASD traits: low/high; anxiety symptoms: low/high), controlling for plausible covariates. In addition, we used a longitudinal design to assess whether neural responses during reward processing predicted anxiety at 2-year follow-up. High ASD traits were associated with reduced BOLD responses in dorsal prefrontal regions during reward anticipation and negative feedback. Participants with high anxiety symptoms showed increased lateral prefrontal responses during anticipation, but decreased responses following feedback. Interaction effects revealed that youth with combined ASD traits and anxiety, relative to other youth, showed high right insula activation when anticipating reward, and low right-sided caudate, putamen, medial and lateral prefrontal activations during negative feedback (all clusters PFWE<0.05). BOLD activation patterns in the right dorsal cingulate and right medial frontal gyrus predicted new-onset anxiety in participants with high but not low ASD traits. Our results reveal both quantitatively enhanced and qualitatively distinct neural correlates underlying the comorbidity between ASD traits and anxiety. Specific neural responses during reward processing may represent a risk factor for developing anxiety in ASD youth.

AB - Up to 40% of youth with autism spectrum disorder (ASD) also suffer from anxiety, and this comorbidity is linked with significant functional impairment. However, the mechanisms of this overlap are poorly understood. We investigated the interplay between ASD traits and anxiety during reward processing, known to be affected in ASD, in a community sample of 1472 adolescents (mean age=14.4 years) who performed a modified monetary incentive delay task as part of the Imagen project. Blood-oxygen-level dependent (BOLD) responses to reward anticipation and feedback were compared using a 2x2 analysis of variance test (ASD traits: low/high; anxiety symptoms: low/high), controlling for plausible covariates. In addition, we used a longitudinal design to assess whether neural responses during reward processing predicted anxiety at 2-year follow-up. High ASD traits were associated with reduced BOLD responses in dorsal prefrontal regions during reward anticipation and negative feedback. Participants with high anxiety symptoms showed increased lateral prefrontal responses during anticipation, but decreased responses following feedback. Interaction effects revealed that youth with combined ASD traits and anxiety, relative to other youth, showed high right insula activation when anticipating reward, and low right-sided caudate, putamen, medial and lateral prefrontal activations during negative feedback (all clusters PFWE<0.05). BOLD activation patterns in the right dorsal cingulate and right medial frontal gyrus predicted new-onset anxiety in participants with high but not low ASD traits. Our results reveal both quantitatively enhanced and qualitatively distinct neural correlates underlying the comorbidity between ASD traits and anxiety. Specific neural responses during reward processing may represent a risk factor for developing anxiety in ASD youth.

U2 - 10.1038/tp.2016.107

DO - 10.1038/tp.2016.107

M3 - SCORING: Journal article

C2 - 27351599

VL - 6

SP - e845

JO - TRANSL PSYCHIAT

JF - TRANSL PSYCHIAT

SN - 2158-3188

ER -