Discrepant results of different tests for antibodies to hepatitis C in children with malignant diseases and in patients on renal replacement therapy
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Discrepant results of different tests for antibodies to hepatitis C in children with malignant diseases and in patients on renal replacement therapy. / Rautenberg, P; Schneppenheim, R; Leimenstoll, G; Behnke, H; Loose, G.
in: EUR J CLIN MICROBIOL, Jahrgang 10, Nr. 11, 01.11.1991, S. 978-81.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Discrepant results of different tests for antibodies to hepatitis C in children with malignant diseases and in patients on renal replacement therapy
AU - Rautenberg, P
AU - Schneppenheim, R
AU - Leimenstoll, G
AU - Behnke, H
AU - Loose, G
PY - 1991/11/1
Y1 - 1991/11/1
N2 - The serostatus of hepatitis C in pediatric oncological patients and in individuals on renal replacement therapy was tested for circulating antibodies to the c100-3 recombinant antigen of hepatitis C. Upon prescreening, 12 of 82 patients in the pediatric oncological group, 6 of 108 renal transplant recipients, and 17 of 150 patients on chronic intermittent hemodialysis were repeatedly positive. Further testing of these 35 sera by supplemental test assays revealed conflicting data, mostly in the pediatric oncological group and in renal transplant recipients. Only in 10 sera were identical results obtained, suggesting that positive test results in some groups at risk have only a low predictive value.
AB - The serostatus of hepatitis C in pediatric oncological patients and in individuals on renal replacement therapy was tested for circulating antibodies to the c100-3 recombinant antigen of hepatitis C. Upon prescreening, 12 of 82 patients in the pediatric oncological group, 6 of 108 renal transplant recipients, and 17 of 150 patients on chronic intermittent hemodialysis were repeatedly positive. Further testing of these 35 sera by supplemental test assays revealed conflicting data, mostly in the pediatric oncological group and in renal transplant recipients. Only in 10 sera were identical results obtained, suggesting that positive test results in some groups at risk have only a low predictive value.
KW - Antigens, Viral
KW - Blood Transfusion
KW - Child
KW - Child, Preschool
KW - Hepacivirus
KW - Hepatitis Antibodies
KW - Hepatitis C
KW - Hepatitis C Antibodies
KW - Humans
KW - Immunoenzyme Techniques
KW - Kidney Transplantation
KW - Neoplasms
KW - Predictive Value of Tests
KW - Renal Dialysis
KW - Viral Nonstructural Proteins
M3 - SCORING: Journal article
C2 - 1724423
VL - 10
SP - 978
EP - 981
JO - EUR J CLIN MICROBIOL
JF - EUR J CLIN MICROBIOL
SN - 0934-9723
IS - 11
ER -