Differences in clinical manifestations of imported versus autochthonous leptospirosis in Austria and Germany.
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Differences in clinical manifestations of imported versus autochthonous leptospirosis in Austria and Germany. / Hoffmeister, Bodo; Peyerl-Hoffmann, Gabriele; Pischke, Sven; Zollner-Schwetz, Ines; Krause, Robert; Müller, Matthias C; Graf, Angelika; Kluge, Stefan; Burchard, Gerd-Dieter; Kern, Winfried V; Suttorp, Norbert; Cramer, Jakob.
in: AM J TROP MED HYG, Jahrgang 83, Nr. 2, 2, 2010, S. 326-335.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Differences in clinical manifestations of imported versus autochthonous leptospirosis in Austria and Germany.
AU - Hoffmeister, Bodo
AU - Peyerl-Hoffmann, Gabriele
AU - Pischke, Sven
AU - Zollner-Schwetz, Ines
AU - Krause, Robert
AU - Müller, Matthias C
AU - Graf, Angelika
AU - Kluge, Stefan
AU - Burchard, Gerd-Dieter
AU - Kern, Winfried V
AU - Suttorp, Norbert
AU - Cramer, Jakob
PY - 2010
Y1 - 2010
N2 - Leptospirosis, a zoonosis occurring worldwide, has a broad spectrum of clinical manifestations. Recently, various countries observed an increase of severe anicteric cases. In Austria and Germany, growing numbers of imported cases are notified in addition to autochthonous infections. The aim of this study was to assess whether imported and autochthonous cases differ in clinical manifestations and outcome. We retrospectively analyzed 24 imported and 35 autochthonous cases treated in six infectious disease units between 1998 and 2008. To compare disease severity, patients were classified according to established independent risk factors for fatal outcome. Although severe leptospirosis (i.e., presence of > or = 1 independent risk factors for death) occurred in similar proportions of imported (67%) and autochthonous (86%) infections (P = 0.1), imported cases were significantly fewer icteric (13% versus 69%; P <0.0001). In conclusion, an increasing incidence of severe anicteric imported cases of leptospirosis should be anticipated with rising global travel activities.
AB - Leptospirosis, a zoonosis occurring worldwide, has a broad spectrum of clinical manifestations. Recently, various countries observed an increase of severe anicteric cases. In Austria and Germany, growing numbers of imported cases are notified in addition to autochthonous infections. The aim of this study was to assess whether imported and autochthonous cases differ in clinical manifestations and outcome. We retrospectively analyzed 24 imported and 35 autochthonous cases treated in six infectious disease units between 1998 and 2008. To compare disease severity, patients were classified according to established independent risk factors for fatal outcome. Although severe leptospirosis (i.e., presence of > or = 1 independent risk factors for death) occurred in similar proportions of imported (67%) and autochthonous (86%) infections (P = 0.1), imported cases were significantly fewer icteric (13% versus 69%; P <0.0001). In conclusion, an increasing incidence of severe anicteric imported cases of leptospirosis should be anticipated with rising global travel activities.
M3 - SCORING: Zeitschriftenaufsatz
VL - 83
SP - 326
EP - 335
JO - AM J TROP MED HYG
JF - AM J TROP MED HYG
SN - 0002-9637
IS - 2
M1 - 2
ER -